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Standardized preparation method and application of traditional Chinese medicine formula granule cream formula

A traditional Chinese medicine formula granule and a technology for formula granules, which are applied in the directions of pharmaceutical formulas, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. There are no quantitative standards and other issues, to avoid quality differences, shorten the time of boiling the paste, and control the end point of the paste

Pending Publication Date: 2021-09-21
LIAONING HUANREN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In traditional paste preparation, the source and quality of medicinal materials are different. In the actual paste preparation process, there is a large gap in the production quantity and quality between different batches; There is no uniform requirement for the number of decoctions, and small differences may affect the decoction of medicinal ingredients and affect the therapeutic effect; the collection of ointment requires rich experience in ointment making, and the final judgment is entirely based on personal experience, which is highly subjective and has no quantitative standards

Method used

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  • Standardized preparation method and application of traditional Chinese medicine formula granule cream formula
  • Standardized preparation method and application of traditional Chinese medicine formula granule cream formula
  • Standardized preparation method and application of traditional Chinese medicine formula granule cream formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 (nourishing liver and kidney formula granule ointment side)

[0045]Using formula granules to make ointment requires experimental research and verification on parameters such as the amount of water added to reconstitute the formula granules, the method of reconstitution, the temperature of water, the temperature of ointment, the time of ointment, the amount of donkey-hide gelatin, the amount of honey, and the amount of citric acid.

[0046] 1. Prescription:

[0047]

[0048] 2. Test method:

[0049] 2.1. Research on reconstitution method

[0050] Weigh two parts of Nourishing Liver and Kidney Paste formula granules on average, one of which is to slowly pour the weighed formula granules into hot water and stir to dissolve, and the other part is to slowly pour hot water into the granules and stir to dissolve , observe the dissolution and record the time, the results are shown in Table 1-1

[0051] Table 1-1 Investigation of the ways of adding water to f...

Embodiment 2

[0094] Embodiment 2 (Pingxin Fumai formula granule ointment side)

[0095]

[0096] 1.1 Dispensing prescription:

[0097] Use the traditional Chinese medicine formula granule dispensing equipment to carry out prescription dispensing and preparation according to a prescription amount, a total of 617g granules.

[0098] 1.2 Reconstitution:

[0099] Add water (802g) that is 1.3 times the total weight of the granules into the pot of the paste square machine, set the heat preservation temperature and paste boiling temperature to 55°C, set the time to 10min, start heating and stirring, when the temperature reaches above 50°C, slowly Slowly add 617g of prepared Chinese medicine formula granules.

[0100] 1.3 Boil ointment:

[0101] After the granules are completely dissolved, set the heat preservation temperature and paste boiling temperature to 85°C for 42 minutes, so that the medicinal liquid is concentrated and gradually becomes a thick clear paste. (At this time, the refra...

Embodiment 3

[0104] Embodiment 3 (Warming and tonifying kidney yang formula granule ointment side)

[0105] Prescription and Prescription Quantity:

[0106]

[0107] 1.1 Dispensing prescription:

[0108] Use the traditional Chinese medicine formula granule dispensing equipment to carry out prescription dispensing and preparation according to a prescription amount, a total of 565g granules.

[0109] 1.2 Reconstitution:

[0110] Add water (735g) that is 1.3 times the total weight of the granules into the pot of the paste square machine, set the heat preservation temperature and paste boiling temperature to 55°C, set the time to 10min, start heating and stirring, when the temperature reaches above 50°C, slowly Slowly add 565g of prepared Chinese medicine formula granules.

[0111] 1.3 Boil ointment:

[0112] After the granules are completely dissolved, set the heat preservation temperature and boiling paste temperature to 85°C for 38 minutes, so that the medicinal liquid is concentrate...

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Abstract

The invention provides a standardized preparation method and application of a traditional Chinese medicine formula granule cream formula, and belongs to the technical field of standardized treatment of traditional Chinese medicines. The cream formula is decocted from traditional Chinese medicine formula granules, the yin nourishing cream formula adopts donkey-hide gelatin as a matrix, the yang tonifying cream formula adopts deer-horn glue as a matrix, the donkey-hide gelatin and the deer-horn glue can also be formula granules prepared from the donkey-hide gelatin and the deer-horn glue, the cream decoction time can be shortened, and the tedious procedure of melting by heat is avoided. The traditional Chinese medicine formula granules are used for preparing the cream formula, the preparation process is standardized by screening and optimizing related process conditions, tests prove that the method can be applied to the traditional Chinese medicine formula granule cream formula with different prescriptions and different doses, the preparation time of the cream formula can be effectively shortened, the quality difference of different batches of cream formula caused by human factors is avoided, and thus the method has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of standardized treatment of traditional Chinese medicines, and in particular relates to a preparation method and application of standardized traditional Chinese medicine formula granules. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] "Ointment" is a traditional Chinese medicine ointment taken for the main purpose of health care, also known as "ointment", which is one of the oldest prescription forms. A pasty oral preparation prepared with excipients such as glue or honey. Based on the overall concept of traditional Chinese medicine, the ointment is widely used in the treatment of diseases in internal ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K36/8984A61K47/46A61K47/12A61P1/14A61P1/16A61P13/12A61K36/9068A61P9/00A61K36/8998A61K35/586A61K33/26A61K35/50A61K35/02A61K35/618A61K35/57A61K35/64A61K35/36
CPCA61K9/06A61K9/0053A61K36/21A61K36/736A61K36/8945A61K36/46A61K36/815A61K36/754A61K36/884A61K35/586A61K36/8968A61K36/8964A61K36/39A61K36/43A61K36/342A61K36/8984A61K36/28A61K36/704A61K36/71A61K36/65A61K36/888A61K36/725A61K36/605A61K33/26A61K36/79A61K36/57A61K36/62A61K36/126A61K35/50A61K36/752A61K36/738A61K36/287A61K36/48A61K36/076A61K36/77A61K36/756A61K36/804A61K36/638A61K36/232A61K36/12A61K36/54A61K36/9068A61K36/60A61K36/344A61K35/02A61K35/618A61K36/84A61K36/237A61K36/286A61K36/185A61K36/537A61K36/488A61K36/481A61K36/69A61K35/57A61K36/00A61K36/284A61K36/484A61K36/296A61K36/64A61K36/746A61K36/714A61K36/487A61K36/52A61K36/899A61K36/73A61K36/236A61K36/234A61K36/8962A61K36/835A61K36/8998A61K35/64A61K36/8905A61K36/88A61K36/233A61K36/539A61K36/87A61K36/238A61K36/346A61K36/9066A61K36/8967A61K36/8888A61K35/36A61K47/46A61K47/12A61P1/14A61P1/16A61P13/12A61P9/00A61K2300/00
Inventor 赫爱平杨玉王辉张可宋祈潼苑鹏翀赵立新
Owner LIAONING HUANREN PHARMA
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