Postoperative monitoring device for kidney transplantation recipient

Abstract

The invention discloses a postoperative monitoring device for a kidney transplantation recipient, and the device comprises: a data collection unit which is used for collecting peripheral blood transcriptome data of the kidney transplantation recipient; a database unit which is used for storing the peripheral blood transcriptome data; and a support vector machine unit which is used for generating a monitoring report based on the peripheral blood transcriptome data. Study data pre-stored in a database unit are called through the support vector machine unit, a classifier model is constructed and tested, and the classifier model predicts the probability of occurrence of postoperative acute rejection of a kidney transplantation recipient based on peripheral blood transcriptome data of the kidney transplantation recipient and generates a detection report. The kidney function condition of a kidney transplantation recipient is accurately monitored while non-invasive detection is achieved, and meanwhile a detection report can provide a theoretical necessary basis for further confirmation and diagnosis of transplantation kidney needle biopsy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a postoperative monitoring device for kidney transplant recipients. Background technique [0002] Acute rejection (AR) is currently a common complication in kidney transplant recipients and has a negative impact on recipient prognosis. Despite the introduction of newer immunosuppressive regimens in recent years, the incidence of AR in kidney transplant recipients remains high, approximately 15% to 20%. In addition, due to the shortage of donor organs, the number of extended standard donor (ECD) kidney transplants is increasing year by year; compared with living donor organs, the incidence of AR in extended standard donor (ECD) kidney transplantation with higher AR rate will increase. The occurrence of allograft AR is associated with severe adverse events such as allograft dysfunction and chronic allograft nephropathy. Meanwhile, AR can occur at any stage after kidney transplan...

AI Technical Summary

Problems solved by technology

[0003] At present, non-specific indicators related to renal function are often used for AR monitoring after transplantation, and their sensitivity and specificity are limited.

Although biopsy of transplanted kidney is the gold standard for the diagnosis of AR, it is an invasive test with risks of infection and low patient compliance.

[0004] In summary, traditional postoperative monitoring devices have the problem that accuracy and safety cannot coexist

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