Preparation method of 3D printing moldable guided bone regeneration membrane

Abstract

The invention relates to a preparation method of a 3D printing moldable guided bone regeneration membrane. The preparation method comprises the following steps that poly (glycerol sebacate) prepolymer and polycaprolactone are dissolved in tetrahydrofuran, sodium chloride particles are added to obtain 3D printing ink, and two layers of 3D printing sheet-shaped brackets are printed; the poly (glycerol sebacate) prepolymer and the polyvinyl alcohol are added into hexafluoroisopropanol to prepare an electrostatic spinning polymer solution, and electrostatic spinning and the 3D printing sheet brackets are assembled together by adopting a vertical electrostatic spinning mode; the assembled bracket is placed at an operation area position on a model for shaping, and washing is carried out after vacuum thermal crosslinking to obtain a porous personalized shaping bracket; and the porous personalized shaping bracket is soaked in a buffer solution to prepare the guided bone regeneration membrane. According to the preparation method, the 3D printing technology, the salting-out technology and the electrostatic spinning technology are utilized, the open porous structure of the guided bone regeneration membrane is achieved, the medicine carrying efficiency is improved, the mechanical strength of the membrane is guaranteed, and lasting enrichment of regenerative macrophages (M2 type) in a bone defect area can be achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical devices, and in particular relates to a preparation method of a 3D printing shapeable guiding bone regeneration membrane. Background technique [0002] Guided bone regeneration (GBR) is a surgical method widely used in oral and maxillofacial surgery, through the placement of barrier membranes to create space for new bone formation and preserve blood clots, while preventing the invasion of surrounding soft tissues, ultimately achieving bone tissue regeneration regeneration. Therefore, the properties of bone-guiding membrane will directly affect the effect of bone regeneration. [0003] The guided bone regeneration membranes widely used clinically mainly include polytetrafluoroethylene-based biodegradable membranes and collagen-based biodegradable membranes. Although the non-biodegradable membrane has good biological stability, the subsequent secondary removal operation has brought unnecessary ...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method of 3D printing shapeable guided bone regeneration membrane, which solves the existing problems of the existing guided bone regeneration membrane such as secondary extraction, rapid degradation, compact structure and poor mechanical strength.

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