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External preparation

A topical agent and selected technology, applied in the field of topical agents containing tranexamic acid, can solve the problems of easy precipitation of crystals and high crystallinity

Pending Publication Date: 2021-09-03
MARUZEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although tranexamic acid is water-soluble, on the other hand, there is a problem that the crystallinity is very high, and crystals are easily precipitated due to the evaporation of water.

Method used

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Embodiment

[0055] Examples and comparative examples are given below to specifically describe the present invention, but the present invention is not limited by the following examples. It should be noted that, in the following examples, unless otherwise specified, "%" in the composition means mass %, ratio means mass ratio, and the amounts of each component in the table are amounts converted from pure components.

[0056] For the following components, a tranexamic acid crystallization inhibition test was performed at the concentrations described in the table. Record the results together in the table.

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Abstract

According to the present invention, an external preparation is configured to contain (A) one or more substances that are selected from among tranexamic acid, tranexamic acid derivatives and salts of tranexamic acid or tranexamic acid derivatives, and (B) one or more substances that are selected from among arginine, aspartic acid, glutamic acid, glycine, proline, serine, threonine, gamma-aminobutyric acid, derivatives of these compounds, and salts of these compounds or the derivatives of these compounds, thereby being capable of suppressing crystallization of tranexamic acid.

Description

technical field [0001] The present invention relates to external preparations containing tranexamic acid. [0002] Background of the invention [0003] Tranexamic acid has hemostatic and anti-inflammatory effects, and is widely used in toothpaste, pharmaceuticals, and the like. In addition, it has a rough skin-improving effect and a whitening effect, and is also used as an external preparation for skin or hair such as cosmetics. [0004] However, although tranexamic acid is water-soluble, on the other hand, there is a problem that crystallinity is very high and crystals are easily precipitated by evaporation of water. As a method for suppressing the crystallization of such tranexamic acid, combined use of phytic acid (Patent Document 1: JP-A No. 2018-48097) and polyhydroxy acid (Patent Document 2: JP-A No. 2013-121955) has been proposed. etc. method. However, a method with a further excellent effect of inhibiting the crystallization of tranexamic acid is desired. [0005]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61P7/04A61P29/00A61P17/00A61Q19/00A61Q5/00A61K9/08A61K8/44A61K47/18A61K47/22
CPCA61P17/00A61Q5/00A61P29/00A61K47/22A61Q19/00A61K8/44A61K31/195A61K47/18A61P7/04A61K9/08
Inventor 池田良岛家圭悟
Owner MARUZEN PHARMA
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