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AZD1208-containing composition with efficacy of treating ophthalmic diseases and preparation method of AZD1208-containing composition

A composition and technology for ophthalmic diseases, applied in the directions of medical preparations containing active ingredients, blood diseases, sensory diseases, etc., can solve problems such as no treatment for eye diseases, and achieve difficult drug resistance, obvious effects, and production. low cost effect

Inactive Publication Date: 2021-09-03
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] AZD1208 is an effective orally available Pim kinase inhibitor. It is currently known to be used in the treatment of proliferative diseases such as cancer. It has also been reported that inhibiting Pim1 can reduce inflammation, but there is no record of its use in the treatment of ocular diseases

Method used

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  • AZD1208-containing composition with efficacy of treating ophthalmic diseases and preparation method of AZD1208-containing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment provides a composition with the efficacy of treating ophthalmic diseases, including the first composition and the second composition with a mass ratio of 1:0.5: the components of the first composition include AZD1208 and AZD1208 with a mass ratio of 1:0.06 disodium edetate; the second composition is prepared from ginseng, honeysuckle, wild chrysanthemum, houttuynia cordata, dandelion and mulberry leaves;

[0026] The preparation method of the second composition comprises steps:

[0027] Put honeysuckle, wild chrysanthemum, Houttuynia cordata, and dandelion into 60% ethanol aqueous solution, adjust the pH value to 8.3, then reflux for extraction for 154 minutes, filter after extraction, and collect the first filtrate; among them, honeysuckle, wild chrysanthemum The ratio of the total mass of Houttuynia cordata and Dandelion to the mass of ethanol aqueous solution is 1:7;

[0028] The mulberry leaves were decocted and extracted for 36 minutes, filtered af...

Embodiment 2

[0034] This embodiment provides a composition with the effect of treating ophthalmic diseases, including the first composition and the second composition with a mass ratio of 1:0.4: the components of the first composition include AZD1208 and AZD1208 with a mass ratio of 1:0.05 disodium edetate; the second composition is prepared from ginseng, honeysuckle, wild chrysanthemum, houttuynia cordata, dandelion and mulberry leaves;

[0035]The preparation method of the second composition comprises steps:

[0036] Put honeysuckle, wild chrysanthemum, Houttuynia cordata, and dandelion into an ethanol aqueous solution with a volume fraction of 55%, adjust the pH value to 8.2, then reflux and extract for 150 minutes, filter after extraction, and collect the first filtrate; among them, honeysuckle, wild chrysanthemum The ratio of the total mass of Houttuynia cordata and Dandelion to the mass of ethanol aqueous solution is 1:6;

[0037] Decoct the mulberry leaves with water for 30 minutes...

Embodiment 3

[0043] This embodiment provides a composition with the effect of treating ophthalmic diseases, including the first composition and the second composition with a mass ratio of 1:0.6: the components of the first composition include AZD1208 and AZD1208 with a mass ratio of 1:0.07 disodium edetate; the second composition is prepared from ginseng, honeysuckle, wild chrysanthemum, houttuynia cordata, dandelion and mulberry leaves;

[0044] The preparation method of the second composition comprises steps:

[0045] Put honeysuckle, wild chrysanthemum, Houttuynia cordata, and dandelion into an ethanol aqueous solution with a volume fraction of 65%, adjust the pH value to 8.4, then reflux and extract for 160 minutes, filter after extraction, and collect the first filtrate; among them, honeysuckle, wild chrysanthemum The ratio of the total mass of Houttuynia cordata, Dandelion to the mass of ethanol aqueous solution is 1:9;

[0046] The mulberry leaves were decocted and extracted for 40...

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Abstract

The invention provides a composition with efficacy of treating ophthalmic diseases. The composition comprises a first composition composed of AZD1208 and disodium ethylene diamine tetraacetate, and a second composition prepared from ginseng, honeysuckle, wild chrysanthemum flower, cordate houttuynia, dandelion and mulberry leaves. The composition is a compound preparation combining traditional Chinese medicine and western medicine, traditional Chinese medicinal materials with different medicine properties are adopted and scientifically matched with the western medicine, and the prepared composition has the efficacy of treating ophthalmic diseases, is obvious in effect, takes effect quickly, treats both symptoms and root causes, and is low in side effects such as allergy and drug resistance.

Description

technical field [0001] The present application belongs to the field of ophthalmic medicine, and specifically, the present application provides a composition containing AZD1208 and having the effect of treating eye diseases and a preparation method thereof. Background technique [0002] The eyes are a very important organ of the human body, and one of the most frequently used organs of the human body. Therefore, if you do not pay attention to protection, eye diseases are prone to occur. Local bacterial infection of the eye, including conjunctivitis, keratitis, corneal ulcer, iritis, eye trauma, chemical injury, infection after eye surgery, etc. Most of the pathogenic bacteria are Pseudomonas aeruginosa and Gram-positive cocci, Such as Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus aureus and Neisseria gonorrhoeae, among which Staphylococcus epidermidis is the first. Conjunctival inflammation is mostly an acute onset, and one or both eyes may be affe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K31/454A61K9/08A61P27/02A61P25/00A61P29/00A61P31/04A61P31/02A61P7/10
CPCA61K31/454A61K36/258A61K36/355A61K36/287A61K36/78A61K36/288A61K36/605A61K9/08A61K9/0048A61K47/183A61P27/02A61P25/00A61P29/00A61P31/04A61P31/02A61P7/10A61K2236/333A61K2236/331A61K2236/51A61K2300/00
Inventor 苏文如谢利辉
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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