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Production method of sulpiride preparation

A production method and sulpiride technology, applied in the production field of sulpiride preparations, can solve problems such as slow dissolution rate, and achieve the effects of good smoothness and high hardness

Inactive Publication Date: 2021-09-03
大桐制药(中国)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a kind of production method of sulpiride preparation, which is used to solve the problem that the disintegration time limit of general sulpiride tablets at the present stage is basically 10-15 minutes, and the dissolution rate is slow, so its dissolution rate still has a large limit. room for improvement

Method used

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  • Production method of sulpiride preparation

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Effect test

Embodiment 1

[0026] A production method of a sulpiride preparation, the sulpiride preparation comprises the following raw materials in parts by weight: 5 parts of sulpiride, 3 parts of lactose, 3.17 parts of microcrystalline cellulose, 0.19 parts of croscarmellose sodium, 0.21 parts of a disintegrant, talc 0.15 parts, 0.28 parts of magnesium stearate, 4.95 parts of purified water;

[0027] The production method of this sulpiride preparation comprises the steps:

[0028] Step S1: Weighing: Under the conditions of indoor temperature of 17°C and humidity of 30%, use a platform scale to accurately weigh the raw materials by weight, and wait for use after the weighing is completed;

[0029] Step S2: Prepare the binding solution: add the weighed purified water into the cleaned and dried pulping tank under the conditions of the indoor temperature of 17°C and the humidity of 30%, then add the disintegrating agent into the purified water, at a speed of 200r / min, stirring at a temperature of 20°C ...

Embodiment 2

[0037] A production method of a sulpiride preparation, the sulpiride preparation comprises the following raw materials in parts by weight: 10 parts of sulpiride, 6 parts of lactose, 6.34 parts of microcrystalline cellulose, 0.38 parts of croscarmellose sodium, 0.42 parts of a disintegrant, talc 0.3 parts, 0.56 parts of magnesium stearate, 9.9 parts of purified water;

[0038]The production method of this sulpiride preparation comprises the steps:

[0039] Step S1: Weighing: under the conditions of indoor temperature of 21.5°C and humidity of 50%, accurately weigh the raw materials by weight on a platform scale, and wait for use after the weighing is completed;

[0040] Step S2: Prepare the binding solution: Add the weighed purified water into the cleaned and dried pulping tank under the condition of the indoor temperature of 21.5°C and the humidity of 50%, then add the disintegrating agent into the purified water, at a speed of 200r / min, stirring at a temperature of 25°C unt...

Embodiment 3

[0048] A production method of a sulpiride preparation, the sulpiride preparation comprises the following raw materials in parts by weight: 15 parts of sulpiride, 9 parts of lactose, 9.51 parts of microcrystalline cellulose, 0.57 parts of croscarmellose sodium, 0.63 parts of a disintegrant, talc 0.45 parts, 0.84 parts of magnesium stearate, 14.85 parts of purified water;

[0049] The production method of this sulpiride preparation comprises the steps:

[0050] Step S1: Weighing: Under the conditions of indoor temperature of 27°C and humidity of 70%, use a platform scale to accurately weigh raw materials by weight, and wait for use after the weighing is completed;

[0051] Step S2: Prepare the binding solution: Add the weighed purified water into the cleaned and dried pulping tank under the condition that the indoor temperature is 27°C and the humidity is 70%. / min, stirring at a temperature of 30°C until the disintegrating agent is completely dissolved to obtain a combined sol...

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Abstract

The invention discloses a production method of a sulpiride preparation, and belongs to the technical field of production of sulpiride preparations. The production method is used for solving the problems that the disintegration time limit of the existing common sulpiride tablet is basically 10 to 15min, the dissolving rate is slow, and the dissolving rate is greatly increased. The production method comprises the following steps of firstly, dissolving a disintegrating agent into purified water, so as to prepare a combining liquid; stirring and mixing sulpiride, lactose, microcrystalline cellulose and croscarmellose sodium, mixing with the combining liquid, and performing wet type mixing and granulating; drying and crushing the wet granules, mixing with talcum and magnesium stearate, and tabletting; and removing metal, and checking, so as to obtain the sulpiride preparation. The produced sulpiride preparation has the advantages that the hardness is higher, the smoothness is better, and the sulpiride preparation is easily accepted by people; by adding the disintegrating agent, the sulpiride preparation can be quickly disintegrated in the use process, the dissolving rate is higher, and the pharmacological action is quickly realized.

Description

technical field [0001] The invention relates to the technical field of production of sulpiride preparations, in particular to a production method of sulpiride preparations. Background technique [0002] Sulpiride, an atypical antipsychotic drug, is a benzamide drug mainly used to treat psychosis, schizophrenia and depression-related diseases. White or off-white crystalline powder, odorless, slightly bitter taste, slightly soluble in ethanol or propanol, very slightly soluble in chloroform, almost insoluble in water, easily soluble in sodium hydroxide solution. At this stage, the general disintegration time limit of sulpiride tablets is basically 10-15 minutes, and the dissolution rate is slow, so there is still a lot of room for improvement in the dissolution rate. Contents of the invention [0003] (1) Solved technical problems [0004] Aiming at the deficiencies in the prior art, the present invention provides a kind of production method of sulpiride preparation, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61K9/20A61K47/38A61K47/26A61K47/02A61K47/12A61P25/18
CPCA61K31/40A61K9/2054A61K9/2018A61K9/2013A61K9/2009A61P25/18
Inventor 张志伟毛杰袁勇
Owner 大桐制药(中国)有限责任公司
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