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Method for extracting quebrachitol from artemisia plants by using water as extraction solvent

A kind of technology of Quina bark alcohol and Artemisia plants, applied in the field of separation and purification of plant components, to achieve the effect of simple and easy decolorization process, high yield and wide source of raw materials

Active Publication Date: 2021-08-20
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a method for extracting Quina bark alcohol in Artemisia plants with water as the extraction solvent, so as to solve the deficiency of the existing Quina bark alcohol extraction process

Method used

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  • Method for extracting quebrachitol from artemisia plants by using water as extraction solvent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 8 kg of crushed Artemisia annua medicinal materials, add 160 kg of pure water, mix well, condense and reflux at 60°C for 3 times, extract for 2 hours each time, combine the extracts, and add 1.0% of the total mass of the extracts to the extracts Chitosan flocculant, after 3 hours of static flocculation, filter to remove impurities to obtain a decolorized extract; the decolorized extract passes through D101 macroporous resin at a flow rate of 1.5BV / h, collects the effluent and concentrates it under reduced pressure at 70°C Obtain 912g of crude extract, add 2.5L of 60% ethanol solution to the crude extract to dissolve it, crystallize at normal temperature, then use 2L of 60% ethanol solution to completely dissolve the crystal, and recrystallize at normal temperature , Obtain 367g of Quaia cortisol crystals.

Embodiment 2

[0028] Take 8kg of crushed Artemisia annua medicinal materials, add 120kg of pure water, mix well, condense and reflux at 70°C and extract for 3 times, extract for 2 hours each time, combine the extracts, and add 0.5% of the total mass of the extracts to the extracts Chitosan flocculant, after static flocculation for 3 hours, filtered to remove impurities, the filtered solution passed through D101 macroporous resin at a flow rate of 1.5BV / h, and the effluent was collected and concentrated under reduced pressure at 70°C to obtain 998g rough soak paste, add 3L of ethanol solution with a volume fraction of 60% to the crude extract to dissolve it, crystallize at room temperature, then use 2L of ethanol solution with a volume fraction of 50% to completely dissolve the crystals, and place it at room temperature for recrystallization , Obtain 351g of Quaia cortisol crystals.

Embodiment 3

[0030] Take 8 kg of crushed Artemisia annua medicinal material, add 200 kg of tap water, mix well, condense and reflux at 75°C and extract for 3 times, extract for 2 hours each time, combine the extracts, and add 1.5% of the total mass of the extract to the extract Chitosan flocculant, after standing for flocculation for 4 hours, filter to remove impurities, the filtered solution passes through D101 macroporous resin at a flow rate of 1.3BV / h, collect the effluent and concentrate under reduced pressure at 65°C to obtain 893g crude extract 1.5 L of ethanol solution with a volume fraction of 60% was added to the crude extract to dissolve it, placed at room temperature for crystallization, and then 2.5 L of ethanol solution with a volume fraction of 55% was used to completely dissolve the crystals, and placed at room temperature for recrystallization. Crystallized to obtain 392 g of quinia cortisol crystals.

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Abstract

The invention discloses a method for extracting quebrachitol from artemisia plants by using water as an extraction solvent. The method comprises the steps of extraction, decoloration, flavone removal, concentration, crystallization and recrystallization. According to the extraction method disclosed by the invention, all components of artemisia plants such as artemisia salicifolia and mugwort can be used for extraction, and the raw material sources are abundant; the water is used as the extraction solvent, the cost is low, the process is simple, and the yield is high; and meanwhile, the use of a toxic solvent is avoided, so that the method is more environment-friendly, and a new method is provided for industrial production of quebrachitol.

Description

technical field [0001] The invention relates to the technical field of separation and purification of plant components, and relates to a method for extracting Quina cortisol from Artemisia plants by using water as an extraction solvent. Background technique [0002] Quina cortexol belongs to cyclopolyols. It has a slightly sweet taste and will not cause blood sugar to rise after ingestion. It is a naturally occurring chiral raw material. In medicine, Quina cortitol is often used to synthesize inositol drugs with high economic value because of its chirality and left-handed optical property; in agriculture, Quina cortitol is also used to synthesize insecticides and inhibitors. Bacteria. The source of raw materials for preparing quebranol is relatively narrow. Currently, it is only found in lychee branches, seabuckthorn fruit, and rubber whey wastewater. Factors such as complexity and large amount of organic solvents lead to inconvenience in industrialized production. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/196C07C41/34C07C41/36C07C41/40C07C41/44
CPCC07C41/34C07C41/36C07C41/40C07C41/44C07C2601/14C07B2200/07C07C43/196
Inventor 陈阳陈志元孙代华王玉李志豪
Owner 劲牌持正堂药业有限公司
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