Preparation device of chiral o-diamine compound and mixing method of preparation device

Abstract

The invention discloses a preparation device of a chiral o-diamine compound and a mixing method of the preparation device. The preparation device comprises a box body and a plurality of supporting legs which are distributed at the lower end of the box body in an array mode; the lower end of each supporting leg is provided with a supporting block used for increasing the supporting area; the lower end of the box body is provided with a discharging pipe used for discharging; the upper end of the box body is provided with a feeding pipe; a feeding hopper is arranged at the upper end of the feeding pipe; a driving motor is arranged in the middle of the upper end of the box body; the output end of the driving motor is fixedly connected with the upper end of a driving shaft; and the lower end of the driving shaft is connected with a buffering pool used for buffering materials. The preparation device of the chiral o-diamine compound and the mixing method are designed for overcoming the defects of existing processing equipment, and optimization is made from the aspect of feeding, so that material spreading is more uniform, and later mixing is facilitated; and in addition, a stirring mode is optimized, longitudinal convection type stirring, circumferential rotary stirring and extrusion expansion convection are constructed, a stirring effect is further optimized, and practicability is high.

Description

technical field [0001] The invention relates to the technical field of chemical equipment, in particular to a preparation device and a mixing method for chiral o-diamine compounds. Background technique [0002] Chiral ortho-diamine compounds are a class of molecules that play a very important role in the research fields of organic synthesis and medicinal chemistry. On the one hand, they exist as core skeletons in many important biological activities and medicinal values: for example, the drug Oseltamvir (Chinese trade name: Tamiflu) for the treatment of influenza A and B; Nutlin-3 is a A highly efficient and selective Mdm2 antagonist with an IC50 of 90nM in a cell-free assay, in which optically pure (-)-Nutlin-3 has a higher activity. It is widely used as a small molecule probe in chemical biology and is used for cancer In the study of chemotherapy treatment (Nature, 2004, 432, 307; Science, 2004, 303, 844). On the other hand, chiral ortho-diamines also play a wide and imp...

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Problems solved by technology

[0003] In the preparation process of chiral o-diamine compounds, equipment for stirring and mixing the raw materials is needed, such as stirring the monovalent silver salt and the chiral bisphosphine ligand at room temperature in an organic solvent under an argon atmosphere. The existing The mixing effect of the mixing equipment is not good, and it is not very helpful to improve the processing quality. Based on this, a preparation device and a mixing method for chiral ortho-diamine compounds are now provided

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