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Composition for improving memory, or composition for preventing and treating alzheimer's disease, comprising angelica root extract and silkworm product having silk protein

A technology of Alzheimer's and Angelica extracts, applied in medical preparations containing active ingredients, drug combinations, peptide/protein ingredients, etc. memory effect

Active Publication Date: 2021-08-06
REPUBLIC OF KOREA (MANAGEMENT RURAL DEV ADMINISTRATION) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, various products for improving memory have been launched, but with little effect, and there are few products that perfectly meet the needs of consumers

Method used

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  • Composition for improving memory, or composition for preventing and treating alzheimer's disease, comprising angelica root extract and silkworm product having silk protein
  • Composition for improving memory, or composition for preventing and treating alzheimer's disease, comprising angelica root extract and silkworm product having silk protein
  • Composition for improving memory, or composition for preventing and treating alzheimer's disease, comprising angelica root extract and silkworm product having silk protein

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0048] The temperature for preparing the above-mentioned extract or fractions thereof may be 20°C to 100°C, but is not limited thereto. The extraction or fractionation time is not particularly limited, but preferably, the extraction is within 10 minutes to 2 days. As the extraction equipment, conventional extraction equipment, ultrasonic pulverization extractor or fractionation machine can be used. The solvent can be removed by hot-air drying, reduced-pressure drying or freeze-drying of the extract or fraction prepared in the above manner. Furthermore, the above-mentioned extract or fraction can be purified and used by column chromatography. The above chromatography can be selected from silica gel column chromatography, LH-20 column chromatography, ion exchange resin chromatography, medium pressure liquid chromatography chromatography), thin layer chromatography (TLC; thin layer chromatography), silica gel vacuum liquid chromatography (silica gel vacuum liquid chromatography)...

Embodiment 1

[0070] Example 1. Preparation of a mixture composed of cooked silkworm processed product and angelica extract

[0071] 1) Prepare cooked silkworm processed product (cooked silkworm; Hong silkworm)

[0072] Breeding golden silkworms with yellow silk protein (the mating species bred by mating the original silkworm 311 of the Japanese germline and the original silkworm 312 of the Chinese germline), before and after the 5th age and 7 days, that is, if it becomes a mature silkworm, use temperature steamed at 100°C for 120 to 130 minutes to prepare a boiled mature silkworm product of a silkworm variety (steamed mature silkworm product or boiledmature silkworm product), and then vacuum freeze-dried the cooked silkworm product of the above-mentioned silkworm variety for 24 hours to prepare powder form.

[0073] 2) Prepare the ethanol extract of Angelica sinensis

[0074] Using Korean Angelica sinensis, the raw material was weighed, and extracted twice at a temperature of 85°C with 7...

experiment example 1

[0077] Experimental example 1. Composition of cooked silkworms before cooking, processed silkworm products, or processed silkworm products of various species Analysis and comparison

[0078] 1) Composition analysis and comparison of cooked silkworms before cooking and cooked silkworm processed products

[0079] The cooked silkworms before cooking and the cooked silkworm processed products were subjected to main component analysis with hammer mill pulverized products having a particle size of 0.1 mm, respectively, and are shown in Table 1 and Table 2 below.

[0080] Table 1

[0081]

[0082]

[0083] Table 2

[0084]

[0085] From the above results, it was confirmed that the contents of various components in cooked silkworms before cooking change in various ways when they become processed silkworm products, and that the above-mentioned cooked silkworm products also change due to changes in the components of the processed silkworm products. Pharmacological effects...

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Abstract

The present invention relates to a composition for improving memory, or a composition for preventing and treating Alzheimer's disease, or a method for preparing said compositions, or a treatment method, wherein said compositions are characterized by comprising a cooked silkworm product and an Angelica root extract as effective components. As the present invention provides compositions using an Angelica root extract and a silkworm product rich in silk proteins and functional materials derived from mulberry leaves to improve memory and prevent or treat Alzheimer's disease, various health supplement products or drugs using the present invention are expected to be developed and commercialized, making it possible to fundamentally prevent and treat aging and dementia associated with aging, which are arising as a major problem in modern societies, and also to provide benefits of memory improvements in various other demographics, such as students, students studying for exams, office workers, etc.

Description

technical field [0001] The present invention relates to a composition for improving memory or a composition for preventing and treating Alzheimer's dementia comprising cooked silkworm processed product having silk protein and Angelica sinensis extract. In more detail, the following composition comprising: Composition for improving memory or preventing and treating Alzheimer's dementia of cooked silkworm processed product of silk protein and angelica extract: Improvement of memory and Alzheimer's dementia with combination Both substances with prophylactic efficacy showed a more pronounced efficacy than the individual substances. Background technique [0002] South Korea's annual fertility rate has declined rapidly. In 2017, the index hit an all-time low of 1.05, which is 0.53 lower than the average of 1.68 in 2015 for member countries of the Organization for Economic Co-operation and Development. The number of births in December 2017 was 25,000 and fewer than 26,900 deaths ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K35/64A23L33/10A23L33/17A23L33/105A61K38/17A61P25/28
CPCA61K38/1767A61P25/28A23L2/02C12G3/05A23C9/152A23C9/1526A61K35/64A61K36/232A23L33/10A23L33/105A61K2300/00A23L33/17A23V2002/00A23V2250/542A23V2200/322A23L2/66
Inventor 池相德金基荣金南淑赵柳英金秀倍金省完金钟吉金永国高暎昊金妸渶崔宝兮阮方朴贤雨徐胄源金辉宋美庚
Owner REPUBLIC OF KOREA (MANAGEMENT RURAL DEV ADMINISTRATION)
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