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Production method of vitamin B6

A production method and vitamin technology, applied in the direction of organic chemistry and the like, can solve problems such as black tar substances, and achieve the effects of reducing organic matter, significant economic benefits, and improving yield

Pending Publication Date: 2021-08-06
安徽泰格维生素发展有限公司
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Problems solved by technology

[0010] In order to solve the above existing problems, the present invention provides a production method of vitamin B6, by separating and utilizing the by-product 2,2'-ethyl oxalamidodipropionate, the yield of the ester acylation reaction step is improved. rate, and solved the problem of black tar substances in the production process

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  • Production method of vitamin B6
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Embodiment 1

[0045] This example provides a production method of vitamin B6. On the basis of the existing technology, the following additions are added: purification of the crude ester acyl product obtained from the normal ester acylation reaction, and the separation of the by-product 2,2'-grass two Ethyl amidodipropionate, and the by-product is hydrolyzed for reuse. The specific steps are:

[0046] (1) Get 3000g of ester acylation crude product (about 89~92% of gas phase purity) of ester acylation reaction and recovery finished benzene, ethanol, diethyl oxalate, drop in the distillation bottle, depressurize to 10~100pa with oil pump, Slowly raise the temperature and rectify, and according to the different temperatures at the top of the tower, collect about 180g of the front fraction before 106°C (this fraction is applied to the normal ester acylation reaction of the next batch), and about 2580g of the normal fraction between 106 and 110°C (ester Pure acyl product with a purity of over 98...

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Abstract

The invention belongs to the technical field of vitamin production, and particularly discloses a production method of vitamin B6. The production method comprises the following steps: distilling and purifying an ester-acyl compound crude product obtained by ester acylation reaction to obtain an ester-acyl compound pure product and a distillation residue containing a byproduct 2, 2 '-oxadiamido ethyl dipropionate; then, hydrolyzing the distillation residues containing the by-product ethyl 2, 2 '-oxadiamido dipropionate; carrying out an ester acylation reaction on the obtained hydrolysate to prepare an ester-acyl compound, and purifying the reaction product to obtain a pure ester-acyl compound product; and using the obtained pure ester acyl for cyclization reaction. The invention provides the production method of vitamin B6, which is characterized in that a byproduct 2, 2 '-oxadiamido ethyl dipropionate is separated and utilized, so that the yield of an ester acylation reaction step is improved, and the problem that black tar substances are generated in the production process is solved.

Description

technical field [0001] The invention relates to the technical field of vitamin production, in particular to a method for producing vitamin B6. Background technique [0002] Vitamin B6 (Vitamin B6), also known as pyridoxine, pyridoxine or pyridoxamine, is an important water-soluble vitamin and an indispensable vitamin for humans and animals, which can participate in various metabolic reactions. Vitamin B6 is mainly used in feed additives, food additives, medicine, cosmetics, etc. [0003] The current process for synthesizing vitamin B6 is the ethoxyxazole process, which is mature and stable, but the disadvantage is that the overall yield is low. The first step in the synthesis of vitamin B6 is the ester acylation reaction. The esterification reaction and the acylation reaction proceed simultaneously. The main product is ester acylation, and various by-products are also produced. During the reaction, alanine, oxalic acid, ethanol, and diethyl oxalate are generally dissolved ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/67
CPCC07D213/67
Inventor 柳道晗杨家友王海肖谦
Owner 安徽泰格维生素发展有限公司
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