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Application of Fenticonazole Nitrate in the Preparation of Antidiabetic Drugs

A technology of fenticonazole nitrate and diabetes medicine, which is applied in the field of medicine, can solve the problems of heart enlargement, edema, weight gain, etc., and achieve the effect of low toxicity and side effects

Active Publication Date: 2022-05-27
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of thiazolidinediones can lead to side effects such as obesity, weight gain, edema, bladder cancer, enlarged heart, and heart failure
These side effects have seriously hindered the clinical application of thiazolidinediones

Method used

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  • Application of Fenticonazole Nitrate in the Preparation of Antidiabetic Drugs
  • Application of Fenticonazole Nitrate in the Preparation of Antidiabetic Drugs
  • Application of Fenticonazole Nitrate in the Preparation of Antidiabetic Drugs

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Experimental program
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Embodiment 1

[0023] 1. Detection of the ability of fenticonazole nitrate to activate PPARγ (luciferase activity assay)

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Abstract

The invention discloses the application of fenticonazole nitrate in the preparation of antidiabetic drugs. Fenticonazole nitrate has a strong affinity with PPARγ at a concentration of 10 μM. And the experiments showed that compared with rosiglitazone, the ability of fenticonazole nitrate to induce adipocyte differentiation was weaker, and fenticonazole nitrate weakly activated the expression of adipogenic genes downstream of PPARγ; in db / db model mice, Fenticonazole nitrate did not cause weight gain in mice, and had no obvious side effects on the internal organs of mice; at the same time, at a concentration of 10 mg / kg, it also had a good hypoglycemic effect. The present invention discovers for the first time that fenticonazole nitrate has a high-efficiency hypoglycemic effect and has low toxic and side effects, and can be developed as an antidiabetic drug.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of fenticonazole nitrate in the preparation of antidiabetic medicines. Background technique [0002] Diabetes mellitus is a common metabolic disease that is increasing at an alarming rate in the world's population and is characterized by hyperglycemia and its associated symptoms due to insufficient insulin secretion, insufficient insulin action, or both. In all diabetic patients, the proportion of non-insulin dependent type 2 diabetes is more than 90%. In type 2 diabetic patients, due to hyperglycemia caused by insulin resistance in the liver and peripheral tissues, diabetic patients require more insulin to maintain the physiological balance of glucose metabolism in the body, which can be achieved by increasing insulin secretion (endogenous production) of pancreatic islets or directly Recombinant peptides are injected to lower blood sugar levels. How...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4174A61P3/10
CPCA61K31/4174A61P3/10
Inventor 易伟马磊周志侯宁唐君源
Owner GUANGZHOU MEDICAL UNIV
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