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ZIF-8/carbon dot anti-biofilm composite nanomaterial and preparation method thereof

A composite nanomaterial, ZIF-8 technology, applied in botany equipment and methods, chemicals for biological control, nanotechnology, etc., can solve the problems of insufficient removal of biofilm, limited application, poor antibacterial performance, etc.

Active Publication Date: 2021-07-30
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial properties of most carbon dots are poor enough to remove biofilms, which limits their application in the field of anti-biofilms (TravlouN A, Giannakoudakis D A, Algarra M, et al. S-and N-doped carbon quantum dots: Surface chemistry dependent antibacterial activity[J].Carbon,2018,135:104-111.)

Method used

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  • ZIF-8/carbon dot anti-biofilm composite nanomaterial and preparation method thereof
  • ZIF-8/carbon dot anti-biofilm composite nanomaterial and preparation method thereof
  • ZIF-8/carbon dot anti-biofilm composite nanomaterial and preparation method thereof

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Embodiment 1

[0024] (1) Put 1 g of lysine (Lys) powder in a crucible, add 6 mL of absolute ethanol, ultrasonicate for 10 min, dry in an oven, and heat in a tube furnace at 240°C for 3 h to obtain a black sintered product. After cooling to room temperature, add 10mL ethanol and 10mL deionized water and soak. 15000rmin after grinding -1 Centrifuge for 10 min and take the supernatant. The supernatant was dialyzed against deionized water for 5 hours, MWCO=1.0KD. The purified lysine carbon dot (Lys-CD) solution was freeze-dried for use.

[0025] (2) Dissolve 50mg Lys-CD in 50mL methanol solution (1mg mL -1 ), weighed 150 mg of zinc nitrate hexahydrate and added it to 50 mL of methanol, added the Lys-CD solution dropwise into the methanol solution of zinc nitrate, and stirred magnetically for 30 min.

[0026] (3) Weigh 300mg of 2-methylimidazole and dissolve it in 50mL of methanol, add dropwise to the mixed solution of Lys-CD and zinc nitrate hexahydrate, stir magnetically for 1h, until a li...

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Abstract

The invention discloses a ZIF-8 / carbon dot anti-biofilm composite nano material and a preparation method thereof. According to the method, a metal organic framework ZIF-8 is taken as a carrier, lysine carbon quantum dots are taken as an antibacterial agent, and the lysine carbon quantum dots are embedded into the ZIF-8 framework under the coordination action of nitrogen-containing groups on the surfaces of the lysine carbon quantum dots and zinc ions, so that the anti-biofilm composite nano material is prepared. Compared with single ZIF-8 and Lys-CD, the ZIF-8 / carbon dot anti-biofilm composite nanomaterial prepared by the invention has the advantages that the anti-biofilm activity is obviously enhanced, meanwhile, the composite material is endowed with good biocompatibility by the Lys-CD, and the ZIF-8 / carbon dot anti-biofilm composite nanomaterial has a wide application prospect in the field of anti-biofilms.

Description

technical field [0001] The invention belongs to the technical field of anti-biofilm composite nanomaterials, and relates to a ZIF-8 / carbon dot anti-biofilm composite nanomaterial and a preparation method thereof. Background technique [0002] Free bacteria are easy to gather on the surface of active tissues or materials and further develop into mature biofilms. Most of the bacterial colonies that are difficult to completely clear are related to the formation of bacterial biofilms. Increasing the dose of antibiotics can easily lead to problems such as unnecessary side effects or drug resistance, making it difficult to eradicate bacterial infections. Therefore, improving the anti-biofilm activity of antibacterial agents and endowing them with good biocompatibility is of great significance for the removal of biofilm. [0003] In recent years, zeolite imidazolate framework (ZIF-8) has been favored by many biomedical researchers due to its good biocompatibility and high specific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61K47/22A61P31/04B82Y5/00B82Y30/00B82Y40/00A01N25/10A01N59/00A01N55/02A01N43/50A01P1/00
CPCA61K47/22A61K33/44A61P31/04A01N25/10A01N59/00A01N55/02A01N43/50B82Y5/00B82Y30/00B82Y40/00Y02A50/30
Inventor 邢晓东张高珂李培礼唐文涛杨旭
Owner NANJING UNIV OF SCI & TECH
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