Preparation device of pregabalin intermediate compound

Abstract

The invention discloses a preparation device of a pregabalin intermediate compound. The device comprises a main body and a straight-through pipe mounted on the main body, wherein a rotary bottle is mounted on the position, close to the corresponding end of the straight-through pipe, of the main body, and a condensation pipe component which can automatically loosen a movable interface and effectively and conveniently dismount the rotary bottle for use in real time is arranged at the position, close to the other end of the straight-through pipe, of the main body. Compared with the prior art, the preparation device of the pregabalin intermediate compound has the advantages that by arranging the condensation pipe component, each interface on the condensation pipe component can be automatically loosened and adjusted in a continuous rotary evaporation process, so that the seizure problem caused by long-term tightening of each connecting component on the condensation pipe is effectively avoided, effective maintenance is performed on the condenser pipe components, and the rotary bottle can be effectively and conveniently dismantled in real time so as to facilitate real-time use of rotary evaporator equipment.

Description

technical field [0001] The invention relates to the technical field of preparing pregabalin intermediate compounds, in particular to a preparation device for pregabalin intermediate compounds. Background technique [0002] Pregabalin is a white or nearly white crystalline powder chemical, which is an antiepileptic drug and is mainly used clinically for the treatment of postherpetic neuralgia. [0003] During the manufacture of pregabalin intermediate compound, it is necessary to add compound 4 (482mg, 2mmol) and 10mL methanol to a 50mL dry three-necked flask, add sodium hydroxide (800mg, 20mmol), and reflux extraction 3 times under stirring , the organic layer was washed twice with saturated brine, dried by adding anhydrous magnesium sulfate, and the solvent was removed by a rotary evaporator, and the intermediate compound was obtained through subsequent operations. [0004] Among them, the rotary evaporator is used as the preparation device of the pregabalin intermediate c...

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Problems solved by technology

[0005] However, at present, the loosening and active maintenance of each interface connector on the condensing tube of the rotary evaporator is mainly done manually one by one, which is time-consuming and labor-intensive, and the hands are prone to fatigue, which will affect the real-time and efficient preparation. processing efficiency, and in the continuous processing and preparation process, it is easy to ignore the loosening and active maintenance of the equipment, which will affect the convenient disassembly and use of the instrument. Therefore, we propose a preparation device for pregabalin intermediate compounds

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