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Anti-MRSA nettle extract, and extraction method and applications thereof

A nettle extract and extraction method technology, applied in the field of anti-MRSA, can solve the problem of little research on monomer compounds, and achieve the effect of reducing cell membrane potential

Inactive Publication Date: 2021-07-23
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Urtica dioica contains a variety of active ingredients, and is rich in phenols, organic acids and flavonoids, which shows that it is expected to be researched and developed as a candidate antibacterial drug, and the current domestic research has just started, involving monomers There are very few studies on the compound, and the antibacterial activity of Urtica dioica is worthy of research and development

Method used

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  • Anti-MRSA nettle extract, and extraction method and applications thereof
  • Anti-MRSA nettle extract, and extraction method and applications thereof
  • Anti-MRSA nettle extract, and extraction method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The activation of the first part of the recipient bacteria and the preparation of the bacteria suspension

[0035] Before conducting research on the antibacterial efficacy and mechanism, it is first necessary to ensure that the tested strain is in an activated state, and prepare a bacterial suspension with an appropriate concentration according to the growth habit of the bacteria for later experimental research.

[0036] 1 Experimental materials

[0037] 1.1 The strains used in the experiment: Staphylococcus aureus SA (resource number: BNCC186053, other number: ATCC25923), methicillin-resistant Staphylococcus aureus MRSA (resource number: BNCC337371, other number: ATCC43300), the above two strains were purchased From Beijing Beina Chuanglian Biotechnology Research Institute, ST5-MRSA and ST239-MRSA are preserved by the Medical Experiment Center of China Three Gorges University and donated by Teacher Wang Decheng of the School of Medicine of China Three Gorges University. ...

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Abstract

The invention relates to an anti-MRSA nettle extract and an extraction method thereof. The anti-MRSA nettle extract is separated and extracted from nettle by using an alcohol solvent. The alcohol solvent is methanol or alcohol, or a combination of the methanol and the alcohol. Applications of the anti-MRSA nettle extract and the extraction method of the anti-MRSA nettle extract in preparation anti-MRSA drugs are also disclosed.

Description

technical field [0001] The invention relates to the technical field of anti-MRSA, in particular to an anti-MRSA nettle extract and its extraction method and application. Background technique [0002] Staphylococcus aureus (Staphylococcus aureus, SA) is an important human pathogen, which was recognized as the cause of pyogenic abscess more than 130 years ago. It belongs to the genus Staphylococcus and is a representative of Gram-positive bacteria. Staphylococcus aureus can invade the body through various channels, leading to various infections of the skin or organs, even sepsis, etc., and can also cause dysfunction of multiple organ systems in the body or cause toxic shock syndrome. The infection can range from mild to severe. Skin and soft tissue infections ranging from life-threatening endocarditis, chronic osteomyelitis, pneumonia, or bacteremia. From the emergence and application of antibiotics such as penicillin and methicillin in the middle of the last century, the eff...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P31/04
CPCA61K36/185A61P31/04A61K2236/33A61K2236/39A61K2236/51A61K2236/55
Inventor 陈涛杜鹃张艳程叶蒯晴叶
Owner CHINA THREE GORGES UNIV
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