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A kind of preparation method of medical antibacterial gauze

A technology of gauze and ascorbic acid, which is used in medical science, biochemical treatment of enzymes/microorganisms, bandages, etc., can solve the problems of low utilization rate of graphene and firm loading of graphene materials, so as to promote wound healing, not easily fall off, and maintain relative drying effect

Active Publication Date: 2021-12-28
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] The present invention is to overcome when the graphene material is used in the gauze in the prior art, due to the lack of affinity between graphene and textiles, it is difficult for the traditional process to firmly load the graphene material on the gauze, the utilization rate of graphene Low; and the problem that graphene alone cannot make gauze have both antibacterial and hemostatic effects, a preparation method for medical antibacterial gauze is provided, by combining graphene oxide with gauze fibers, and then obtaining graphene nanosheets through in situ reduction The gauze is tightly wrapped with fibers, and the cyclodextrin containing thrombin anchors the graphene on the surface of the gauze, making a medical gauze with good antibacterial and hemostatic functions

Method used

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  • A kind of preparation method of medical antibacterial gauze

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Embodiment 1

[0033] A preparation method of medical antibacterial gauze, comprising the steps of:

[0034] (1) Pre-dry the absorbent cotton gauze after washing, the pre-drying temperature is 135°C, and the pre-drying time is 2.5 minutes;

[0035] (2) Modified hydroxypropyl-β-cyclodextrin: the degreased cotton yarn is arranged in the finishing solution for padding treatment, and the components of the finishing solution include in parts by weight: 3 parts of hydroxypropyl-β-cyclodextrin, 7.5 parts of citric acid, 2 parts of sodium dihydrogen phosphate, and 100 parts of water; the liquid-carrying rate of the gauze after padding treatment is 102%; then carry out steam cross-linking, the cross-linking temperature is 150 ° C, the steam cross-linking time is 3 minutes, and after washing with water, it is obtained Hydroxypropyl-β-cyclodextrin modified gauze;

[0036] (3) Modified graphene: immerse the gauze modified by hydroxypropyl-β-cyclodextrin in the graphene oxide dispersion with a concentra...

Embodiment 2

[0039] A preparation method of medical antibacterial gauze, comprising the steps of:

[0040] (1) Pre-dry the absorbent cotton gauze after washing, the pre-drying temperature is 130°C, and the pre-drying time is 3min;

[0041](2) Modified hydroxypropyl-β-cyclodextrin: the degreased cotton yarn is arranged in the finishing solution for padding treatment, and the components of the finishing solution include in parts by weight: 2 parts of hydroxypropyl-β-cyclodextrin, 7 parts of citric acid, 1 part of sodium dihydrogen phosphate, and 90 parts of water; after padding, the liquid retention rate of the gauze is 110%; then steam cross-linking is carried out, the cross-linking temperature is 140 ° C, the steam cross-linking time is 5 minutes, and after washing with water, the obtained Hydroxypropyl-β-cyclodextrin modified gauze;

[0042] (3) Modified graphene: immerse the gauze modified by hydroxypropyl-β-cyclodextrin in the graphene oxide dispersion with a concentration of 1 mg / mL, ...

Embodiment 3

[0045] A preparation method of medical antibacterial gauze, comprising the steps of:

[0046] (1) Pre-dry the absorbent cotton gauze after washing, the pre-drying temperature is 140°C, and the pre-drying time is 2min;

[0047] (2) Modified hydroxypropyl-β-cyclodextrin: the degreased cotton yarn is arranged in the finishing solution for padding treatment. The components of the finishing solution include in parts by weight: 5 parts of hydroxypropyl-β-cyclodextrin, 8 parts of citric acid, 3 parts of sodium dihydrogen phosphate, and 110 parts of water; the liquid-carrying rate of the gauze after padding treatment is 100%; then steam cross-linking is carried out, the cross-linking temperature is 180 ° C, the steam cross-linking time is 2 minutes, and after washing with water, the obtained Hydroxypropyl-β-cyclodextrin modified gauze;

[0048] (3) Modified graphene: immerse the gauze modified by hydroxypropyl-β-cyclodextrin in the graphene oxide dispersion with a concentration of 3 ...

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Abstract

The invention discloses a preparation method of medical antibacterial gauze, which comprises the following steps: (1) modifying hydroxypropyl-β-cyclodextrin: arranging the gauze in a finishing method containing hydroxypropyl-β-cyclodextrin and citric acid Padding treatment in liquid, then steam crosslinking, and washing with water to obtain gauze modified with hydroxypropyl-β-cyclodextrin; (2) Modified graphene: impregnating gauze modified with hydroxypropyl-β-cyclodextrin In the graphene oxide dispersion, add ascorbic acid, heat the reaction, take it out and wash it with water to get the graphene-modified gauze; (3) Inclusion of thrombin: soak the graphene-modified gauze in the thrombin solution for a shock reaction; after taking it out Washed with water and dried with cold air to obtain the medical antibacterial gauze. The invention anchors the graphene on the surface of the gauze through cyclodextrin containing thrombin to prepare the medical gauze with good antibacterial and hemostatic functions.

Description

technical field [0001] The invention relates to the technical field of medical gauze, in particular to a preparation method of medical antibacterial gauze. Background technique [0002] Medical gauze is a consumable widely used in hospitals. It is mainly used for wound dressing to prevent microorganisms from entering wound tissue, facilitate wound protection, and promote rapid wound healing. Gauze usually uses a sterile base cloth woven from cotton fibers. Although it has the advantages of being cheap and easy to use, it does not have antibacterial and hemostatic properties, and it is easy to breed bacteria in the wound, causing wound infection and causing secondary damage. Therefore, it is very necessary to develop antibacterial gauze with good antibacterial and hemostatic functions. [0003] Antibacterial technology based on nanomaterials has the advantages of simple synthesis, low cost, and can be customized according to requirements. Among them, graphene material is a n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M15/03D06M11/74D06M16/00D06M23/02A61L15/18A61L15/28A61L15/32A61L15/44A61L15/46D06M101/06
CPCD06M15/03D06M11/74D06M16/003D06M23/02D06M16/00A61L15/28A61L15/18A61L15/32A61L15/44A61L15/46D06M2101/06
Inventor 赖登明赖登国徐琦陈笑笑钭金法黄寿奖舒强
Owner ZHEJIANG UNIV
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