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Nano-gold cone composite material with photothermal/photodynamic therapy performance and its preparation method and application

A technology of photodynamic therapy and nano-gold cones, which is applied in photodynamic therapy, preparation of organic compounds, luminescent materials, etc., can solve the problems of no relevant reports in the field of antibacterial, and achieve the effect of improving targeting and efficient bactericidal function

Active Publication Date: 2021-10-08
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an excellent thermotherapeutic agent, nano-gold cones are mainly used in anticancer at present, and there are no relevant reports on the application in the field of antibacterial

Method used

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  • Nano-gold cone composite material with photothermal/photodynamic therapy performance and its preparation method and application
  • Nano-gold cone composite material with photothermal/photodynamic therapy performance and its preparation method and application
  • Nano-gold cone composite material with photothermal/photodynamic therapy performance and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Synthesis of modified AIE photosensitizer

[0038] Synthetic route for modified AIE photosensitizer figure 1 As shown, specifically includes the following steps:

[0039] (1) 4,4'-dihydroxybenzophenone and 1,4-dibromobutane preparation compound 2:

[0040] 4,4'-dihydroxybenzophenone (10 mmol), potassium carbonate (4 mmol), 1,4-dibromobutane (25 mmol) were sequentially added in a 250 ml round mouth flask. It was reduced to room temperature, filtered, and the filter cake was purified with anhydrous ethanol, water washed, dried, and the compound 2 (8.95 mmol) was obtained, the yield was 89.5%, and the compound 2 had a chemical structure as shown below:

[0041]

[0042] figure 2 For the nuclear magnetic spectrum spectrum of Compound 2, the hydrogen spectrum data is as follows: 1 H NMR (600MHz, CDCL 3 Δ7.78 (D, J = 8.7 Hz, 4H), 6.95 (D, J = 8.7 Hz, 4H), 4.08 (T, J = 6.0 Hz, 4H), 3.51 (T, J = 6.6Hz, 4H) 2.15 (m, 4H), 2.05 (m, 4h).

[0043] (2) Compound 2 and 4-hydro...

Embodiment 2

[0049] Example 2 Synthesis of Modified Nano Gold Cape

[0050] (1) Preparation of Naimware cone by seed growth method:

[0051] Add (9.5 mL) h in a 50 ml centrifuge tube. 2 O, (0.25 mL) 0.01 m sodium citrate solution, (0.1 mL) 0.01 M chloroethylate, (0.15 mL) 0.01 m borohydride solution, 30 ° C water bath heating 2h, prepared seed solution. (10 mL) 0.01 M chloroaceous acid solution, (2 mL) 0.01 M silver nitrate solution, (8 mL) 1M hydrochloric acid solution, (8 mL) 1M hydrochloric acid solution, (2 ml) 0.1 m L-ascorbic acid solution, prepared culture solution. Finally, (7.5 mL) seed solution was added to (15 mL) culture solution and stored at 28 ° C for 5 hours, and the solution color was transformed into dark red.

[0052] (2) nano-gold cone purification:

[0053] The above solution was centrifuged for 10 min, and the rotational speed was 8000 ARAD / min. The obtained deposit was dispersed in (400 mL) 0.1M of the hexadalkyltrimethylcylammonium chloride solution, added (4 mL) 0.01...

Embodiment 3

[0056] Example 3 Synthesis of Nanoiner Composites

[0057] The SH-PEG-COOH modified nano-gold cone (0.1 mmol) was dissolved in pure water, sequentially added (1- (3-dimethylaminopropyl) -3-ethyl carbon diimide hydrochloride (0.1 mmol) N-hydroxy succinimide (0.1 mmol), after activation of half an hour, add modified AIE photosensitive Tpe-2AS (0.1 mmol), after 12 hours, filtration, water washing, using transmission electron microscope Testing it, Image 6 Indicated.

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Abstract

The invention discloses a nano gold cone composite material with photothermal / photodynamic therapy performance and its preparation method and application. The nano gold cone composite material is composed of modified nano gold cones and connected on the surface of the modified nano gold cones The modified AIE photosensitizer constitutes; the modified nano-gold cone is a nano-gold cone modified by thiol and carboxyl; the modified AIE photosensitizer is an AIE photosensitizer connected with a quaternary ammonium root cation; the modified AIE photosensitizer is designed to be a There are two molecules of quaternary ammonium salts, which are equivalent to two "anchors", which can better interact with negatively charged bacterial membranes in bacteria and improve the targeting of nanosystems. This nanosystem can realize photodynamic therapy and Due to the synergistic effect of photothermal therapy, AIE photosensitizers can also be used for aggregation-induced luminescence imaging, which can be potentially applied to the integrated research of clinical bacterial diagnosis and treatment.

Description

Technical field [0001] The present invention relates to the field of new material techniques, and more particularly to nano-gold cone composite materials having photothermal / photodynamic therapeutic properties and methods and applications thereof. Background technique [0002] The bacterial infection has seriously threatened human health, although antibiotics have been controlled to bacterial infections, but due to extensive use of antibiotics, more and more bacteria have a drug resistance, "super bacteria" The appearance is more snowy. Therefore, overcoming the clinical problems caused by bacterial drug resistance, finding new antibacterial materials and antibacterial methods are current research hotspots in the field of antibacterial field. [0003] Photodynamic therapy and photothermal therapy can effectively inhibit bacterial resistance during antibacterial process, which makes both increasing attention in antibacterial fields. Unfortunately, small molecular photosensitizer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00C09K11/02C09K11/06C09K11/58C07C213/02C07C217/20C07C45/64C07C49/84C07C41/30A61K41/00A61P31/04
CPCA61K41/0052A61K41/0057A61K49/0021A61P31/04C07C41/30C07C45/64C07C213/02C09K11/02C09K11/06C09K11/58A61K2300/00C07C217/20C07C49/84C07C43/23
Inventor 王佰亮张衡瑞秦楠朱康宁高强褚晓莹曹小文杨梅
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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