Synthesis method of degradable block copolymer hydrogel

A technology of a block copolymer and a synthesis method, which is applied in the field of synthesis of degradable block copolymer hydrogel, can solve the problem that the phase transition temperature of hydrogel cannot be controlled within the range of human body temperature, lactide, glycolide The monomers are not easily available, the grid structure is unstable, etc., and the synthesis method is simple and feasible, the elongation at break is large, and the conditions are mild.

Active Publication Date: 2021-06-25
SHANDONG GUYUCHUN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan, polyvinyl alcohol, acrylamide, sodium alginate and other hydrogels have problems such as insufficient mechanical strength, unstable grid structure, short maintenance time in vivo, and sudden release of drugs. The phase transition of most hydrogels The temperature can never be controlled within the range of human body temperature
Patent CN105131264A discloses a copolymer hydrogel of PEG and polyethylene lactide, which has advantages in biocompatibility and degradation control, and the phase transition temperature can also be controlled within the body temperature range of the human body. However, lactide, glycolide Ester monomers are not easy to obtain, and the preparation cost is high, resulting in high cost of hydrogel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 200g of ε-CL monomer and 30g of PEG1200, carry out dehydration pretreatment with molecular sieve respectively, weigh 0.053g of zinc lactate (mole ratio of monomer to 8000), mix the catalyst and reactant at 8062:1 and inject it into a three-necked flask, Introduce nitrogen, control the temperature of the liquid in the three-necked flask at 100°C, and react for 2 hours to obtain the crude product of PCL-PEG-PCL block copolymer. The color of the product is pure white. The crude product is dissolved in cold water at 0-5°C and heated to Precipitate three times at 60-80°C, freeze-dry to constant weight to obtain the finished product. Yield 86%.

Embodiment 2

[0017] Weigh 200g of ε-CL monomer and 30g of PEG1500, carry out dehydration pretreatment with molecular sieve respectively, weigh 0.07g of stannous octoate (mole ratio of monomer to 10000) 10153:1, mix catalyst and reactant and inject into a three-necked flask , feed nitrogen, control the temperature of the liquid in the three-necked flask at 120°C, and react for 4 hours to obtain the crude product of PCL-PEG-PCL block copolymer. The product color is pure white, and the crude product is dissolved in cold water at 0-5°C and heated. Precipitate three times at 60-80°C, freeze-dry to constant weight to obtain the finished product. Yield 89%.

Embodiment 3

[0019] Weigh 200g of ε-CL monomer and 20g of PEG2000, carry out dehydration pretreatment with molecular sieve respectively, weigh 0.051g of magnesium octanoate (mole ratio of monomer to 12000) 11934:1, mix the catalyst and the reactant and inject it into the three-necked flask, Introduce nitrogen, control the temperature of the liquid in the three-necked flask at 150°C, and react for 6 hours to obtain the crude product of PCL-PEG-PCL block copolymer. The color of the product is pure white. The crude product is dissolved in cold water at 0-5°C and heated to Precipitate three times at 60-80°C, freeze-dry to constant weight to obtain the finished product. Yield 88%.

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PUM

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Abstract

The invention belongs to the field of biological medicine and chemical industry, and particularly relates to a synthesis method of degradable block copolymer hydrogel. The degradable block copolymer hydrogel is obtained by copolymerization of epsilon-caprolactone and polyethylene glycol as raw materials, and the synthesis method comprises the specific steps: weighing epsilon-caprolactone and polyethylene glycol, respectively carrying out water removal pretreatment on the epsilon-caprolactone and the polyethylene glycol by using a molecular sieve, adding the epsilon-caprolactone and the polyethylene glycol into a reactor, adding a catalyst, and reacting for 2-6 hours at the temperature of 100-150 DEG C under the protection of nitrogen to obtain a PCL-PEG-PCL block copolymer crude product; and dissolving, precipitating and drying the crude product to obtain the PCL-PEG-PCL degradable block copolymer hydrogel. The hydrogel has biocompatibility and degradability, the gel phase transition temperature (LCST) is within the human body temperature range, the used raw materials are easy to obtain and low in price, and the synthesis method is simple and easy to implement.

Description

technical field [0001] The invention belongs to the field of biomedicine and chemical industry, and in particular relates to a synthesis method of a degradable block copolymer hydrogel. Background technique [0002] Hydrogel is a cross-linked network formed by hydrophilic polymers under the action of chemical bonds, hydrogen bonds or van der Waals forces. maintain the original structure". Compared with other synthetic materials, hydrogel is closer to living tissue, its surface has weaker adhesion to proteins and cells, and has good biocompatibility when in contact with human tissue, blood and body fluids. In addition, because the hydrogel has a three-dimensional network structure, metabolites can be excreted through it without affecting the metabolic process of living organisms. Due to the above-mentioned characteristics of hydrogel, it has a bright application prospect in the fields of tissue engineering and biomedicine (such as drug sustained release carrier, tissue engi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/664C08G63/78
CPCC08G63/664C08G63/78C08G2230/00
Inventor 赵春华袁文博王文静李建
Owner SHANDONG GUYUCHUN BIOTECHNOLOGY CO LTD
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