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Electromagnetic radiation animal brain injury model and construction method thereof

An electromagnetic radiation and damage model technology, applied in the field of medicine, can solve problems such as obstacles to research and development of prevention and treatment drugs, and failure to construct and evaluate electromagnetic radiation animal brain injury models.

Active Publication Date: 2021-06-25
ACADEMY OF MILITARY MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still no good method to construct and evaluate the brain injury model of electromagnetic radiation animals, which has created obstacles for the development of prevention and treatment drugs.

Method used

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  • Electromagnetic radiation animal brain injury model and construction method thereof
  • Electromagnetic radiation animal brain injury model and construction method thereof
  • Electromagnetic radiation animal brain injury model and construction method thereof

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Embodiment Construction

[0026] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0027] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0028] The embodiment of the present application provides a method for constructing an electromagnetic radiation animal brain injury model, including: setting electromagnetic radiation conditions, and performing electromagnetic radiation treatment on the experimental animal; comparing the calcium activity of the hippocampal CA2 neuron of the experimental animal before and after the electromagnetic radiation treatment, if calcium If the amount of activity change is statistically significant, the electromagnetic radiation conditions are used to construct an electromagnetic radiation a...

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Abstract

The invention discloses an electromagnetic radiation animal brain injury model construction method, and the method comprises the following steps: setting electromagnetic radiation conditions, and carrying out electromagnetic radiation treatment on a test animal; comparing the calcium activities of neurons in the hippocampus CA2 region of the experimental animal before and after the electromagnetic radiation treatment, and if the calcium activity variation has statistical significance, constructing the electromagnetic radiation animal brain injury model by using the electromagnetic radiation condition. According to the method, the electromagnetic radiation animal brain injury model can be well constructed, and possibility is increased for clarification of the molecular mechanism of the electromagnetic radiation brain injury effect and research and development of prevention and treatment drugs.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to an electromagnetic radiation animal brain injury model and its construction method. Background technique [0002] The brain is an important sensitive target organ damaged by electromagnetic radiation. Epidemiological surveys have shown that long-term low-dose electromagnetic radiation can cause abnormal EEG and brain dysfunction in those exposed to radiation. In severe cases, abnormal behavior, neurasthenia, insomnia, dreaminess, and memory loss may occur. Another report pointed out that electromagnetic radiation may increase the risk of Alzheimer's disease. Experimental studies on animals have shown that electromagnetic radiation can lead to declines in spatial reference memory, short-term memory, long-term memory, and motor learning and memory, accompanied by behavioral abnormalities such as anxiety and excitement. The above hints that ele...

Claims

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Application Information

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IPC IPC(8): A61D7/00A01K29/00
CPCA61D7/00A01K29/005
Inventor 李杨左红艳郝延辉喻超刘亚东胡翠翠叶雨萌金星
Owner ACADEMY OF MILITARY MEDICAL SCI
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