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Serum metabolism marker for diagnosis of gestational diabetes mellitus and application of serum metabolism marker

A technology of diabetes and biomarkers, applied in the field of serum metabolic markers, can solve problems such as delayed time, unfavorable treatment, and lack of diagnostic criteria

Active Publication Date: 2021-06-22
南芯芯仪(广州)制造有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The diagnostic criteria of GDM have undergone changes, but there has been a lack of uniform diagnostic criteria around the world until the publication of the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study in 2008, International Diabetes and Pregnancy Research Group (IADPSG) develops new diagnostic criteria for GDM
However, GDM can only be diagnosed in the late second or third trimester, and the serological screening for GDM is carried out at 24-28 weeks of gestation. For the entire pregnancy, the time is later, which is not conducive to treatment

Method used

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  • Serum metabolism marker for diagnosis of gestational diabetes mellitus and application of serum metabolism marker
  • Serum metabolism marker for diagnosis of gestational diabetes mellitus and application of serum metabolism marker
  • Serum metabolism marker for diagnosis of gestational diabetes mellitus and application of serum metabolism marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The inventors identified metabolic markers based on the analysis of metabolites in serum samples of a total of 21 patients with gestational diabetes mellitus (GDM) and 22 age-matched healthy pregnant women in the GDM group.

[0076] 1. Patient enrollment and sample collection

[0077] Peripheral blood samples were all from He Xian Memorial Hospital, Panyu District, Guangzhou. Pregnant women were recruited in Guangzhou during 2019-2020. Mothers with obvious diabetes before pregnancy were not included. After obtaining written consent, a structural medical history was recorded.

[0078] All pregnant women included in the study were registered at the Perinatal Medicine Outpatient Clinic of He Xian Memorial Hospital and followed up on a regular basis. They met the inclusion and exclusion criteria. Special personnel collected the basic information of the patients, such as height, weight, age, etc. Pre-pregnancy body mass index (BMI) is calculated by dividing the weight (kg) ...

Embodiment 2

[0108] Further use the receiver operating characteristic (ROC) curve to consider the diagnostic performance of two differential metabolites. The ROC curve is based on a series of different binary classification methods (cut-off value or decision threshold), with the true positive rate (sensitivity) as the vertical axis , the false positive rate (1-specificity) is a curve drawn on the abscissa. The closer the ROC curve is to the upper left corner, the higher the diagnostic accuracy of the marker. The point of the ROC curve closest to the upper left corner is the best threshold with the least errors, and the total number of false positives and false negatives is the least. The area under the ROC curve (AUC) of each potential marker can be calculated to judge the diagnostic value of the potential marker, and the larger the AUC, the greater the diagnostic value.

[0109] The AUC values ​​of the two differential metabolites were: sphingomyelin SM (8:0; 2O / 11:0): AUC=0.775, 95% CI: ...

Embodiment 3

[0117] Example 3 Detection Verification

[0118] Randomly select 100 blood samples clinically diagnosed as GDM and 100 healthy samples. The levels of sphingomyelin SM (8:0; 2O / 11:0) and oleoylcarnitine CAR (18:2) in the 200 samples were detected by referring to the method of Example 1.

[0119] The results showed that in 19 samples, the level of sphingomyelin SM (8:0; 2O / 11:0) was abnormally up-regulated, and in 9 samples, the level of oleoylcarnitine CAR (18:2) was abnormally down-regulated, of which 5 samples of sphingomyelin SM (8:0; 2O / 11:0) levels were abnormally upregulated and oleoylcarnitine CAR(18:2) levels were abnormally downregulated.

[0120] After reviewing the source of samples, the 23 abnormal samples were all from GDM patients.

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Abstract

The invention provides a serum metabolism marker for diagnosis of gestational diabetes mellitus and application of the serum metabolism marker. Specifically, sphingomyelin SM (8:0; 2O / 11:0) and oleoyl carnitine CAR (18:2) can serve as a biomarker of gestational diabetes mellitus, can be used for evaluating the disease risk of the gestational diabetes mellitus or diagnosing the gestational diabetes mellitus, and have the advantages of high accuracy and strong sensitivity, so that that the serum metabolism marker has an important clinical application value.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular, the invention relates to a serum metabolic marker for diagnosing gestational diabetes and its application. Background technique [0002] Gestational diabetes mellitus (GDM) refers to varying degrees of abnormal glucose tolerance that occurs or is discovered for the first time during pregnancy. If it occurs in the first trimester of pregnancy, the possibility of abnormal glucose tolerance already existing before pregnancy cannot be ruled out. GDM is one of the most common complications during pregnancy. About 3%-8% of pregnant women develop GDM during pregnancy. It is particularly noteworthy that the incidence of GDM continues to rise with the increase in the obesity rate of women of childbearing age. [0003] Gestational diabetes not only has adverse effects on pregnancy, such as spontaneous abortion, deformity, growth retardation in the first trimester, delayed lung maturation in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/92G01N33/50G01N30/02G01N30/06G01N30/72G01N27/62A61K49/00
CPCG01N33/92G01N33/50G01N30/02G01N30/06G01N30/72G01N27/62A61K49/0008G01N2800/042G01N2800/50G01N2800/52
Inventor 陈涛张静袁昕昕王珊霞林金飞
Owner 南芯芯仪(广州)制造有限公司
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