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Hydrogel dressing for wound healing and preparation method thereof

A hydrogel and gelatin technology, applied in medical science, bandages, etc., can solve the problems of difficulty in showing efficacy, complex preparation process, high cost, etc., and achieve the effects of accelerating wound healing, depositing collagen, and promoting the formation of new blood vessels.

Active Publication Date: 2021-06-22
江苏奥普莱医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional wound dressings that passively promote healing often fail to show the desired efficacy
Although various drugs or cells have been introduced to accelerate the healing process, this strategy is often limited, including side effects of drugs, complicated preparation process and high cost

Method used

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  • Hydrogel dressing for wound healing and preparation method thereof
  • Hydrogel dressing for wound healing and preparation method thereof
  • Hydrogel dressing for wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: the preparation of PNIPAm-P hydrogel

[0045] First, polymethacrylic acid (PMAA) (6 kDa) was synthesized by conventional radical polymerization and incubated overnight with NaOH to obtain the sodium salt form of PMAA-Na. Next, a NIPAm solution (solution A) having a concentration of 100 mg / mL was prepared by dissolving a certain amount of N-isopropylacrylamide (NIPAm) in water. Then, a gelatin solution (solution B) having a concentration of 25 mg / mL was prepared by dissolving a certain amount of gelatin in water. Next, solution B, PMAA-Na (25 mg / mL) and crosslinker Bis were slowly added to solution A (solution C). After uniform mixing, the solution C in N 2 Bubble down for 30 minutes to remove oxygen. Finally, the initiator APS and accelerator TEMED were added to solution C and reacted at 4 °C for 6–8 hours to obtain PNIPAm-P hydrogel. After gelling, the hydrogel was taken out and cut into small pieces, soaked in PBS for 30 min, and rinsed 3 times befor...

Embodiment 2

[0046] Embodiment 2: the preparation of PNIPAm hydrogel

[0047] First, a NIPAm solution having a concentration of 100 mg / mL (solution A) was prepared by dissolving a certain amount of N-isopropylacrylamide (NIPAm) in water. Next, a gelatin solution (solution B) having a concentration of 25 mg / mL was prepared by dissolving a certain amount of gelatin in water. After solutions A and B are uniformly mixed, in N 2 Bubble down for 30 minutes to remove oxygen. Finally, the initiator APS and accelerator TEMED were added to the mixed solution and reacted at 4 °C for 6–8 hours to obtain PNIPAm hydrogel. After gelling, the hydrogel was taken out and cut into small pieces, soaked in PBS for 30 min, and rinsed 3 times before use. The hydrogel can be stored freeze-dried.

Embodiment 3

[0048] Embodiment 3: the preparation of PAAm-P hydrogel

[0049] First, polymethacrylic acid (PMAA) (6 kDa) was synthesized by conventional radical polymerization and incubated overnight with NaOH to obtain the sodium salt form of PMAA-Na. Next, an AAm solution having a concentration of 100 mg / mL was prepared by dissolving a certain amount of acrylamide (AAm) in water (solution D). Then, a gelatin solution having a concentration of 25 mg / mL was prepared by dissolving a certain amount of gelatin in water (solution B). Next, solution B, PMAA-Na (25 mg / mL) and crosslinker Bis were slowly added to solution D (solution E). After uniform mixing, solution E was dissolved in N 2 Bubble down for 30 minutes to remove oxygen. Finally, the initiator APS and accelerator TEMED were added to solution E, and reacted at 4°C for 6-8 hours to obtain PAAm-P hydrogel. After gelling, the hydrogel was taken out and cut into small pieces, soaked in PBS for 30 min, and rinsed 3 times before use. ...

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Abstract

The invention discloses a hydrogel dressing. The hydrogel dressing is semi-interpenetrating network hydrogel which is obtained by carrying out free radical polymerization reaction on poly (N-isopropylacrylamide), polymethylacrylic acid and gelatin. The invention also discloses a preparation method of the hydrogel dressing. The hydrogel dressing disclosed by the invention is composed of thermal-response tough adhesive hydrogel, combines the characteristics of high ductility, toughness, tissue adhesion, macrophage reaction change and the like, and has the effects of mechanical activity and immunoregulation. The dressing can strongly adhere to the skin and actively shrink the wound in response to exposure of skin temperature to accelerate wound healing. The novel mechanical treatment and biological-free method is expected to be widely used in various medical environments.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a hydrogel dressing for wound healing and a preparation method thereof. Background technique [0002] Wounds of various types, including acute postoperative wounds, traumatic wounds, burns and chronic wounds resulting from diabetes or circulatory disorders, remain a major clinical concern with significant implications for patients and society. Wound healing is an important physiological process involving evolutionarily conserved sequences of hemostasis, inflammation, proliferation and tissue remodeling. A key process during the wound healing response is the restoration of the epithelial layer to restore the integrity of the skin barrier. Although various wound dressings such as gauze, cotton wool, and hydrogels have been widely used, existing adhesive wound dressings cannot satisfactorily treat large or chronic wounds due to their slow and passive healing behavior. To prom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0052A61L26/0038A61L26/0014A61L26/008A61L26/009C08L89/00C08L33/02C08L33/24
Inventor 胡佳颖陈倩刘庄
Owner 江苏奥普莱医疗用品有限公司
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