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Degradable hemostatic sponge as well as preparation method and application thereof and degradable drug-loaded hemostatic sponge

A hemostatic sponge and drug-loading technology, which can be used in applications, drug delivery, and pharmaceutical formulations. It can solve the problems of slow water absorption, polyurethane residue, and poor support strength of the hemostatic sponge, and achieve excellent biocompatibility and water-locking ability. Strong, fast water absorption effect

Active Publication Date: 2021-06-22
HANGZHOU VITEX MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN202010225321.7 discloses that starch and glycerin are used as raw materials to form hemostatic sponge through freeze-drying process; Chinese patent CN201510545987.X discloses that starch, polyethylene glycol and gallic acid are used as raw materials to form hemostatic sponge through freeze-drying process, but The hemostatic sponge prepared by the freeze-drying process disclosed in the patent has a slow water absorption rate and poor support strength after absorbing water
[0005] The commercially available Nasopore can maintain support for a long time after surgery, but after it degrades, there will be more polyurethane residues that cannot be degraded

Method used

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  • Degradable hemostatic sponge as well as preparation method and application thereof and degradable drug-loaded hemostatic sponge
  • Degradable hemostatic sponge as well as preparation method and application thereof and degradable drug-loaded hemostatic sponge
  • Degradable hemostatic sponge as well as preparation method and application thereof and degradable drug-loaded hemostatic sponge

Examples

Experimental program
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preparation example Construction

[0043] In the present invention, the preparation method of the cross-linked modified starch preferably comprises the following steps:

[0044] Mixing starch and water for gelatinization reaction to obtain a gelatinized starch solution;

[0045] The gelatinized starch solution is mixed with a cross-linking agent to carry out a cross-linking reaction to obtain a cross-linked modified starch.

[0046] The invention mixes starch and water to carry out gelatinization reaction to obtain a gelatinized starch solution. In the present invention, the starch is preferably one or more of potato starch, tapioca starch, corn starch, sweet potato starch and wheat starch, more preferably potato starch or corn starch; in the present invention, the starch and The mass concentration of the starch solution obtained after water mixing is preferably 0.5-20%, more preferably 1.5-15%, most preferably 2.5-12%; the present invention has no special requirements for the specific implementation process o...

Embodiment 1

[0086] Weigh 100.0g of potato starch into the reactor, add 4900ml of water into the reactor, set the temperature of the jacketed reactor to 80°C, and stir at 200rpm for 1 hour; reduce the temperature of the jacketed reactor to 50°C, and use a concentration of 1mol / L NaOH solution to adjust the pH of the reaction solution to 9, use a constant pressure titration funnel to add 10ml of epichlorohydrin aqueous solution dropwise to the reaction solution, and react at a constant temperature for 4 hours. After the reaction is completed, the reaction solution is poured out. Precipitate the product with 1 L of absolute ethanol, wash the product 2 to 3 times with 2 L of absolute ethanol, and dry at 50°C for 24 hours to obtain cross-linked modified potato starch;

[0087] Weigh 1.0g carboxymethylcellulose into 39ml water, stir at 400rpm in a water bath at 40°C for 4 hours to completely dissolve carboxymethylcellulose into a uniform transparent gel, and use 1mol / L HCl to adjust the pH of ca...

Embodiment 2

[0094] Cross-linking modified potato starch synthetic method is with embodiment 1;

[0095] Weigh 0.5g of hydroxyethyl cellulose into 29.5mL of purified water, put it in a water bath at 50°C and stir at 400rpm for 2 hours to completely dissolve the hydroxyethyl cellulose into a uniform transparent gel, and use 1mol / L HCl to adjust the hydroxyethyl cellulose The pH of the solution was 3, cooled to room temperature for subsequent use;

[0096] Weigh 2.5g of cross-linked potato starch into 67.5mL of purified water, stir to absorb water and pour into hydroxyethyl cellulose solution, stir at 400rpm for 30min to mix evenly, after mixing evenly, use 1mol / L HCl to adjust the pH of the solution to 6 , put it in a centrifuge tube, set the centrifugation speed at 5000rpm, and centrifuge for 10min to remove the air bubbles in the solution.

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Abstract

The invention belongs to the technical field of hemostatic materials, and particularly relates to degradable hemostatic sponge as well as a preparation method and application thereof. The degradable hemostatic sponge provided by the invention is prepared by freeze-drying raw materials including cross-linked modified starch and cellulose, the mass ratio of the cross-linked modified starch to the cellulose is (0.2-5): 1. The degradable hemostatic sponge provided by the invention is high in water absorption rate, large in water absorption amount, high in supporting strength after water absorption and long in supporting time; and the plant-derived raw material can be completely biodegraded. According to the degradable drug-loaded starch hemostatic sponge, the drug-loaded coating is attached to the surface of the sponge, slow release of drugs is achieved through slow degradation of auxiliary materials in the drug coating, and the drug release time equivalent to the supporting time of the sponge can be achieved by adjusting ingredients of the auxiliary materials, after the degradable drug-loaded starch hemostatic sponge is put into an acting part for hemostasis, the drug is slowly released while the support is maintained.

Description

technical field [0001] The invention belongs to the technical field of hemostatic materials, and in particular relates to a degradable hemostatic sponge, a preparation method and application thereof, and a degradable drug-loaded hemostatic sponge. Background technique [0002] At present, there are a wide variety of hemostatic materials on the market, with starch and its derivatives, chitosan and its derivatives, gel, cellulose and its derivatives, alginate, and polyurethane as the main raw materials, and they have been maturely used in clinical practice. . [0003] As one of the most common plant polysaccharides, starch is extracted from plants. It has a wide range of sources, is renewable, is of high quality and low price, and is safe in source. It can avoid adverse reactions caused by impurities in animal-derived materials. Its excellent biocompatibility has been Widely used in food, medical and other aspects. Starch is enzymatically hydrolyzed into glucose in the human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/04A61L31/04A61L31/14A61L31/16A61K9/70A61K47/36A61K47/38
CPCA61L24/0036A61L24/0042A61L24/0015A61L24/043A61L31/148A61L31/16A61L31/146A61L31/041A61K9/70A61K47/36A61K47/38A61L2300/606A61L2300/602A61L2400/04A61L2300/424C08J9/28C08J2201/026C08J2301/32C08J2207/10C08J2201/0484C08J2303/04C08L3/00C08L1/02A61L15/28A61L15/425A61L15/44A61L15/64A61L2300/222A61L2300/40A61L2300/604A61L2300/802
Inventor 曹佩培赵中武冠亚
Owner HANGZHOU VITEX MEDICAL DEVICE CO LTD
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