Application of injection composition containing chlorogenic acid in preparation of injection with skin whitening effect

Abstract

The invention provides application of an injection composition containing chlorogenic acid and diammonium glycyrrhizinate in preparation of an injection with a skin whitening effect, and belongs to the field of medicines. According to the composition disclosed by the invention, the chlorogenic acid is used as a main active component, the diammonium glycyrrhizinate is used as an auxiliary component, and the diammonium glycyrrhizinate can effectively enhance the skin whitening effect of the chlorogenic acid, so that the dosage of the chlorogenic acid is reduced. Pharmacodynamic experiments show that the composition containing chlorogenic acid and diammonium glycyrrhizinate has a remarkable inhibition effect on synthesis of melanin, and the effect of the composition is obviously superior to that of single use of chlorogenic acid or tranexamic acid.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of an injection composition comprising chlorogenic acid and diammonium glycyrrhizinate in the preparation of an injection with skin whitening effect. Background technique [0002] Melanin is a biological pigment synthesized by animal melanocytes, which can absorb ultraviolet rays to protect the skin from ultraviolet rays. However, in the modern society with rapid economic development, the pollution is becoming more and more serious, resulting in the formation and expansion of the ozone hole, which makes the human skin absorb more and more ultraviolet rays; coupled with the increase in the pressure of modern urban life, Irregular work and rest time, such as staying up late and using low-quality cosmetics, etc., these factors will cause the melanocytes to synthesize melanin and cause various pigmentation disorders, such as sunburn, chloasma and so on. Pigmentation disor...

AI Technical Summary

Problems solved by technology

But they have their own shortcomings: kojic acid has the potential risk of causing cancer in the list of three types of carcinogens published by the International Agency for Research on Cancer of the World Health Organization; tranexamic acid, also known as tranexamic acid, is a hemostatic drug. Long-term infusion of tranexamic acid has an impact on blood coagulation function, leading to early menstruation, reduced menstruation, even amenorrhea, slowed blood flow, reduced metabolism, and formation of thrombus; the effect of arbutin on melanin content is bidirectional, that is, it can inhibit melanin at a certain concentration. The synthesis of melanin, and the content of melanin can be increased in another concentration range

It can be seen that the active ingredients in the current whitening products for injection are not satisfactory, and there are more or less defects in safety and effectiveness.

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