Method for treating kidney disorders
A technology for effective treatment of chronic kidney disease, applied in chemical instruments and methods, pharmaceutical formulations, medical preparations containing active ingredients, etc.
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[0047] This example demonstrates that administration of APOM to a clinically relevant in vivo model of Alport syndrome prevents renal failure, as well as abnormal lipid content in the renal cortex.
[0048] Materials and methods:
[0049] Construction and use of human recombinant APOM protein : The protein was purchased from Sino Biological (13495-H02H). The DNA sequence encoding human APOM protein (O95445) (Met 1-Asn 188) was fused at the C-terminus to the Fc region of human IgG1. The resulting human recombinant APOM protein was found to be >85% pure as determined by SDS-PAGE and had an endotoxin concentration of <1.0 EU per μg of protein as determined by the LAL method.
[0050] deployment : Proteins were lyophilized from sterile PBS (pH 7.4) and typically 5%-8% trehalose, mannitol and 0.01% Tween 80 were added as protectants before lyophilization. Specific concentrations are included in the hard copy of each COA. For injection, sterile water is added to vials to prep...
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