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Bionic trachea constructed by three-dimensional printing composite aerogel and preparation method thereof

A composite aerogel and three-dimensional printing technology, which can be applied in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of high cost and cumbersome processing methods, and achieve simple technology, good repeatability, and excellent customization performance Effect

Active Publication Date: 2021-05-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a three-dimensional printing composite aerogel to construct an imitation air tube and its preparation method, which overcomes the limitations of the prior art in using the organism's own tissue to extract materials, and the defects of cumbersome processing methods and high cost

Method used

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  • Bionic trachea constructed by three-dimensional printing composite aerogel and preparation method thereof
  • Bionic trachea constructed by three-dimensional printing composite aerogel and preparation method thereof
  • Bionic trachea constructed by three-dimensional printing composite aerogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Configure polylactic acid (molecular weight 300000, Guangzhou Maipu Regenerative Medicine Co., Ltd.) / gelatin (Beijing Yinuokai, innochem, B76801) spinning solution: mix 0.2g gelatin and 0.8g polylactic acid (mass ratio is 1:4 ) was dissolved in 10 mL of hexafluoroisopropanol (>99%, Shanghai Darui Chemical Co., Ltd.), with a mass fraction of 10%.

[0055] (2) Preparation of biological nanofiber membrane by electrospinning: Inhale the polylactic acid / gelatin spinning solution into the syringe, control the advance rate of the micro-injection pump to 2.0mL / h, connect the high-voltage power supply of 12.5KV to the needle of the syringe, and receive it with aluminum foil. , the receiving distance was 13cm, and gelatin / polylactic acid nanofiber membrane was obtained by electrospinning. The nanofiber membrane needs to be vacuum-dried for 24 hours at a vacuum degree of -25KPa and a drying temperature of 25°C.

[0056] (3) Homogenate pulverization of biological nanofiber mem...

Embodiment 2

[0071] (1) Configure polylactic acid (molecular weight 300000, Guangzhou Maipu Regenerative Medicine Co., Ltd.) / gelatin (Beijing Yinuokai, innochem, B76801) spinning solution: mix 0.2g gelatin and 0.8g polylactic acid (mass ratio is 1:4 ) was dissolved in 10 mL of hexafluoroisopropanol (>99%, Shanghai Darui Chemical Co., Ltd.), with a mass fraction of 10%.

[0072] (2) Preparation of biological nanofiber membrane by electrospinning: Inhale the polylactic acid / gelatin spinning solution into the syringe, control the advance rate of the micro-injection pump to 2.0mL / h, connect the high-voltage power supply of 12.5KV to the needle of the syringe, and receive it with aluminum foil. , the receiving distance was 13cm, and gelatin / polylactic acid nanofiber membrane was obtained by electrospinning. The nanofiber membrane needs to be vacuum-dried for 24 hours at a vacuum degree of -25KPa and a drying temperature of 25°C.

[0073] (3) Homogenate pulverization of biological nanofiber mem...

Embodiment 3

[0090] (1) Configure polylactic acid (molecular weight 300000, Guangzhou Maipu Regenerative Medicine Co., Ltd.) / gelatin (Beijing Yinuokai, innochem, B76801) spinning solution: mix 0.2g gelatin and 0.8g polylactic acid (mass ratio is 1:4 ) was dissolved in 10 mL of hexafluoroisopropanol (>99%, Shanghai Darui Chemical Co., Ltd.), with a mass fraction of 10%.

[0091] (2) Preparation of biological nanofiber membrane by electrospinning: Inhale the polylactic acid / gelatin spinning solution into the syringe, control the advance rate of the micro-injection pump to 2.0mL / h, connect the high-voltage power supply of 12.5KV to the needle of the syringe, and receive it with aluminum foil. , the receiving distance was 13cm, and gelatin / polylactic acid nanofiber membrane was obtained by electrospinning. The nanofiber membrane needs to be vacuum-dried for 24 hours at a vacuum degree of -25KPa and a drying temperature of 25°C.

[0092] (3) Homogenate pulverization of biological nanofiber mem...

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Abstract

The invention relates to a bionic trachea constructed by three-dimensional printing composite aerogel and a preparation method thereof. The preparation method comprises the following steps: pouring and molding a crushed fiber mixed solution and a hollow round tube bracket in a mold, crosslinking, carrying out heat treatment, and soaking to obtain the bionic trachea. The polylactic acid / gelatin aerogel provided by the invention has a nanofiber structure, and is a porous and extrudable sponge structure material with excellent water absorption. The material obtained by the method can promote the formation of cartilage cell matrix, and provides effective support for long-term stability of bionic tracheal structure functions.

Description

technical field [0001] The invention belongs to the field of imitation air tube and its preparation, in particular to a three-dimensional printing composite airgel to construct an imitation air tube and a preparation method thereof. Background technique [0002] The trachea is a vascularized hollow tube that connects the larynx to the lungs. A variety of diseases can cause tracheal stenosis, affect ventilation function, and even cause suffocation in severe cases, which is life-threatening. Currently, the gold standard treatment is to restore tracheal continuity using tracheectomy, ie resection of the trachea followed by anastomosis of the opposite end for reconstruction. Other treatments include tracheal stenting or sliding tracheoplasty. All of the above treatments have had varying degrees of success, but no clinically viable option is available for patients with long-segment airway obstruction. For adult tracheal stenosis defect length < 6cm, children tracheal stenos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/22A61L27/50A61L27/52A61L27/56B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/18A61L27/222A61L27/50A61L27/52A61L27/56B33Y10/00B33Y70/10B33Y80/00A61L2430/22A61L2400/12C08L67/04
Inventor 莫秀梅袁征超沈威陈玉杰
Owner DONGHUA UNIV
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