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Preparation method of water gel for scar film

A film and scar technology, which is applied in the field of preparation of scar film with water glue, can solve the problems of low air permeability, easily hindering sweat evaporation and heat dissipation, and insignificant scar effect.

Inactive Publication Date: 2021-05-18
昆山优瑞森医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the air permeability of existing silicone gel dressings is low (less than 400g / m2 / day), which easily causes wound infiltration and slows down wound healing, and also easily hinders sweat evaporation and heat dissipation, causing allergies, while existing polyurethane dressings Tablets were also not significantly effective in reducing scar formation

Method used

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  • Preparation method of water gel for scar film
  • Preparation method of water gel for scar film
  • Preparation method of water gel for scar film

Examples

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preparation example Construction

[0020] The preparation method of scar film water glue, comprises the steps:

[0021] Step A: In a closed nitrogen environment, mix hydrophobic or hydrophilic polyols with a molar ratio of 1:1 to 1:10 and hydrophobic or hydrophilic diisocyanates, and stir to react to obtain the first prepolymer ;

[0022] Step B: In a closed nitrogen environment, add a cross-linking agent to the first prepolymer according to a molar ratio of 2:0.1 to 2:1, stir and react, and cross-link to obtain a second prepolymer. Linking agent is polyether diamine, and described polyether diamine cross-linking agent can be polyethylene glycol diamine (polyethylene glycol diamine), polypropylene glycol diamine (polypropylene glycol diamine) or its combination, and described second prepolymer The weight average molecular weight range of 30,000~60,000g / mol.

[0023] Step C: In an airtight nitrogen environment, add a silane compound to the second prepolymer at a molar ratio of 1:0.1 to 1:1, stir and react, and...

Embodiment 1

[0037] The preparation method of scar film water glue, comprises the steps:

[0038] Step a1: In a closed nitrogen environment, mix 1,1,1-trimethylolpropane (TMP) and hexamethylene diisocyanate (HDI) at a molar ratio of 1:3, and add 0.05wt% Triethylenediamine (triethylenediamine, TEDA) (with the total weight of TMP and HDI being 100wt%) was used as a catalyst, stirred and reacted at 80°C for 90min, and monitored the ebb and flow of the NCO characteristic peak at 2270cm-1 by FT-IR. Obtain a triisocyanate intermediate;

[0039] Step a2: In a closed nitrogen atmosphere, mix the triisocyanate intermediate with polypropylene glycol triol (PPG4000triol) at a molar ratio of 1:3, and add 0.05wt% TEDA (based on the ratio of the triisocyanate and PPG triol) The total weight is 100wt%) as a catalyst, stirred and reacted at 80° C. for 90 minutes, and utilized FT-IR to monitor the ebb and flow of the NCO characteristic peak at 2270 cm −1 to obtain a hydrophobic polyol with six hydroxyl gr...

Embodiment 2

[0046] The preparation method of scar film water glue, comprises the steps:

[0047] Step a1: In a closed nitrogen environment, mix triethanolamine and methylenedicyclohexyl diisocyanate at a molar ratio of 1:2, and add 0.05 wt% triethylenediamine (TEDA) (with TMP and The total weight of HDI is 100wt%) as a catalyst, stirred and reacted for 90min at 80°C, and utilized FT-IR to monitor the ebb and flow of the NCO characteristic peak at 2270cm-1 to obtain a triisocyanate intermediate;

[0048] Step a2: In a closed nitrogen environment, mix the triisocyanate intermediate with polytetramethylene ether glycol triol at a molar ratio of 1:4, and add 0.05 wt% TEDA (based on the triisocyanate and The total weight of PPG triol is 100wt%) as a catalyst, stirred and reacted for 90min at 80°C, and utilized FT-IR to monitor the ebb and flow of the NCO characteristic peak at 2270cm-1 to obtain a hydrophobic polyol with six hydroxyl groups;

[0049] Step b: In a closed nitrogen environment, ...

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Abstract

The invention discloses a preparation method of water gel for a scar film, and relates to the field of water gel, and the preparation method comprises the following steps: step A, in a closed nitrogen environment, mixing hydrophobic polyol and hydrophilic diisocyanate, and stirring for reaction to obtain a first prepolymer; step B, in a closed nitrogen environment, adding a cross-linking agent into the first prepolymer, stirring for reaction, and cross-linking to obtain a second prepolymer; and step C, in a closed nitrogen environment, adding a silane compound into the second prepolymer, and carrying out stirring reaction, so that the end of the second prepolymer is sealed, and the water gel for the scar film is obtained; and step D, adding water-absorbing materials such as carboxymethyl vitamin C (CMC), powdery vitamin C, sodium alginate and the like into the water gel to obtain the functional water gel for the scar film. The water gel for the scar film is obtained by reacting hydrophobic polyhydric alcohol with hydrophilic diisocyanate and carrying out partial crosslinking and end capping. The water gel has good water absorption and air permeability, proper moisture retention and peel strength, can effectively block ultraviolet light penetration and inhibit bacteria, and has obvious effects on wound healing and scar generation reduction.

Description

technical field [0001] The invention relates to the field of water glue, in particular to a preparation method of water glue for scar films. Background technique [0002] The existing nursing patch for removing scars usually uses silicone gel (silicone gel) dressing patch or polyurethane (PU) dressing, which has a fixed support effect for the wound, and is waterproof and has good moisturizing effect. [0003] However, the air permeability of existing silicone gel dressings is low (less than 400g / m2 / day), which easily causes wound infiltration and slows down wound healing, and also easily hinders sweat evaporation and heat dissipation, causing allergies, while existing polyurethane dressings Tablets were also ineffective in reducing scar formation. Contents of the invention [0004] The technical problem to be solved by the present invention is to provide a scar film that has good air permeability, proper moisture retention and peel strength, can effectively block the pene...

Claims

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Application Information

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IPC IPC(8): C09J175/08C08G18/48C08G18/50C08G18/83
CPCC09J175/08C08G18/4829C08G18/4833C08G18/482C08G18/5021C08G18/837
Inventor 陈思贤陈敬伦陈盈珊张腊梅
Owner 昆山优瑞森医疗科技有限公司
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