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Application of piperidine-1-dithioformate-3-methyl-1, 4-dioxo-1, 4-dihydronaphthalene-2-methyl ester

A technology of dithioformic acid and dihydronaphthalene, applied to piperidine-1-dithioformic acid-3-methyl-1, which can solve problems such as limitations

Active Publication Date: 2021-05-11
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dopamine-producing cells in the brain gradually lose their ability to affect the nervous system, limiting the patient's ability to control their muscles

Method used

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  • Application of piperidine-1-dithioformate-3-methyl-1, 4-dioxo-1, 4-dihydronaphthalene-2-methyl ester
  • Application of piperidine-1-dithioformate-3-methyl-1, 4-dioxo-1, 4-dihydronaphthalene-2-methyl ester
  • Application of piperidine-1-dithioformate-3-methyl-1, 4-dioxo-1, 4-dihydronaphthalene-2-methyl ester

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Embodiment Construction

[0011] The application of piperidine-1-dithiocarboxylic acid-3-methyl-1,4-dioxo-1,4-dihydronaphthalene-2-methyl ester in the preparation of preparations for treating Parkinson's disease.

[0012] Experimental procedure

[0013] 1. Preparation of Parkinson's animal model

[0014] 12-week-old C57BL / 6J male mice were induced with PD model mice by intraperitoneal injection of neurotoxin MPTP (N-methyl-4-phenyl-l, 2,3,6-tetrahydropyridine). Three days before administration, the mice were subjected to a series of behavioral trainings such as rotating the rod and climbing poles every day. Try to select mice with the same level of exercise ability to avoid the influence of individual differences, and divide them into two groups. One group is the normal saline group, and the other is the MPTP group. Then intraperitoneal injection of MPTP (20mg / kg / day) was performed for one week, and then the behavioral evaluation was performed. Compared with control mice (injected with the same vol...

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Abstract

The invention discloses application of piperidine-1-dithioformate-3-methyl-1, 4-dioxo-1, 4-dihydronaphthalene-2-methyl ester in treatment of Parkinson's disease. Experimental results show that a Parkinson's model (PD) mouse is given PKM2-IN-1 in an intragastric administration mode, and the medicine can remarkably relieve PD related symptoms, such as recovering the number of dopaminergic neurons at the substantia nigra part, improving expression of tyrosine hydroxylase at the midbrain part and improving the motor ability and the olfactory function of the mouse.

Description

technical field [0001] The present invention relates to the use of a compound piperidine-1-dithiocarboxylic acid-3-methyl-1,4-dioxo-1,4-dihydronaphthalene-2-methyl ester. Background technique [0002] Parkinson's disease (PD), also known as Parkinson's disease, is the second largest neurodegenerative disease after Alzheimer's disease and seriously affects the quality of human life. According to statistics, one out of every 800 people in the world suffers from Parkinson's disease. By 2030, due to the acceleration of the aging process, the prevalence rate of Parkinson's disease will double, and it is estimated that there will be more than 9 million patients. The direct medical costs of the patients are estimated to be over US$10,000 per year, placing a heavy burden on families and society. Parkinson's disease is characterized by progressive, multiple, and insidious onset. The main manifestations are slowness of movement, muscle rigidity, resting tremor, and postural instabili...

Claims

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Application Information

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IPC IPC(8): A61K31/4453A61P25/16
CPCA61K31/4453A61P25/16
Inventor 孙诚王玥珺
Owner NANTONG UNIVERSITY
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