Rat sleep deprivation combined constraint stress device

Abstract

The invention relates to animal experiment equipment, and in particular relates to a rat sleep deprivation combined constraint stress device. The rat sleep deprivation combined constraint stress device comprises a water tank and several platform units; the water tank is arranged on a bottom frame; the several platform units are arranged in the water tank at intervals; a rat is placed on each platform unit; and each platform unit comprises a hollow pipe vertically arranged in the water tank, a platform mechanism arranged on the hollow pipe and a lifting mechanism arranged in the hollow pipe, and is used for performing sleep deprivation on rats placed on the platform units and enabling the rats to fall into the hollow pipe for constraint stress through the movement of the platform mechanism and the lifting mechanism. Based on an improved multi-platform sleep deprivation method and a constraint stress method in the invention, the platform unit comprising the platform mechanism and the lifting mechanism is adopted, so that sleep deprivation and constraint stress can be carried out in the same device at the same time; sleep deprivation on the rats can be carried out at night; furthermore, intermittent constraint stress operation can be carried out in the daytime; and therefore, the animal experiment can be completed more stably and efficiently.

Description

Technical field[0001]The present invention relates to an animal experimental equipment, specifically a rat sleep deprivation combined binding stress device.Background technique[0002]Insufficient sleep is a serious social public health problem. As the modern social pressure increases, people sleep time gradually decrease, there are various degrees of sleep deprivation. Chronic should be one of the main factors that lead to human sub-health status, which is greatly valued by people. It is of great significance to study the effects of sleep deprivation and stress response to human physiological functions. However, the research on injury mechanism after sleep deprivation is still inadequate, and clinical is not satisfactory. Therefore, the establishment of a sleep deprivation combined binding storm-type special device has become an extremely important study in the field of medical research in the field, which is of great significance for exploring sleep deprivation of combined binding t...

AI Technical Summary

Problems solved by technology

[0004] At present, the biggest shortcomings of the existing devices are as follows: 1. Sleep deprivation and restraint stress tests cannot be unified on one device. If it is carried out in sections, it cannot completely simulate the state of people's sleep reduction and stress damage at the same time. After sleep deprivation, repeated removal from the sink for restraint stress will easily lead to excessive participation of human factors and affect the experimental results; 2. The water tank is made of stainless steel, which is opaque and cannot simulate the circadian rhythm; at the same time, the number of operating platforms for the water tank increases Finally, the 10 rats required for the experiment need to be raised in the same cage for 2 weeks before the experiment, which itself adds many uncertain factors to the experiment

3. The water tank is heavy, cannot be moved freely and is not conducive to cleaning work

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