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A Mesoporous Polydopamine Nanoparticle for Tumor T1-T2 Magnetic Resonance Imaging

A mesoporous polydopamine and nanoparticle technology, applied in the field of biomedical materials, can solve the problems of not having T1-T2 dual-mode imaging effect and limiting the application of tumor diagnosis and treatment, and achieve good photothermal conversion ability, accurate MRI results, good contrast effect

Active Publication Date: 2022-02-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This anti-cancer diagnostic agent is prepared by encapsulating metal precursors without metal doping, but it does not have T1-T2 dual-modal imaging effects, which limits its application in the integration of tumor diagnosis and treatment

Method used

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  • A Mesoporous Polydopamine Nanoparticle for Tumor T1-T2 Magnetic Resonance Imaging
  • A Mesoporous Polydopamine Nanoparticle for Tumor T1-T2 Magnetic Resonance Imaging
  • A Mesoporous Polydopamine Nanoparticle for Tumor T1-T2 Magnetic Resonance Imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of manganese-mesoporous polydopamine nanoparticles by doping method before polymerization

[0052] (1) Dissolve 90 mg of dopamine hydrochloride and 3 mg of manganese sulfate hydrate in 3 mL of ultrapure water (the mass ratio of dopamine hydrochloride to manganese sulfate hydrate is 30:1; the mass-volume ratio of manganese sulfate hydrate to ultrapure water is 1 mg:1 mL) , Stir at 180rpm in the dark for 24h to obtain a manganese chelate-dopamine solution;

[0053] (2) the 0.3mL manganese chelation-dopamine solution of 36mg surfactant F127 and step (1) is joined in the mixed solution of 6mL ethanol and 6mL ultrapure water (the mass volume ratio of F127 and manganese chelation-dopamine solution is 120mg: 1mL, the volume ratio of ethanol, ultrapure water and manganese chelation-dopamine solution is 20:20:1), and stirred at 180rpm in the dark for 20min; figure 1 Shown in (1), manganese chelation-dopamine solution, F127 are dispersed in the mixed soluti...

Embodiment 2

[0057] Example 2 Preparation of manganese-mesoporous polydopamine nanoparticles by doping method before polymerization

[0058] (1) 99mg dopamine hydrochloride and 3mg manganese sulfate hydrate are dissolved in 3.75mL ultrapure water (the mass ratio of dopamine hydrochloride and manganese sulfate hydrate is 33:1; the mass volume ratio of manganese sulfate hydrate and ultrapure water is 1mg:1.25 mL), 150rpm avoid light and stir for 26h, obtain manganese chelation-dopamine solution;

[0059] (2) join the manganese chelation-dopamine solution of 30mg surfactant F127 and 0.3mL step (1) in the mixed solution of 4.8mL ethanol and 4.8mL ultrapure water (the mass volume of F127 and manganese chelation-dopamine solution Ratio is 100mg:1mL, the volume ratio of ethanol, ultrapure water and manganese chelation-dopamine solution is 20:20:1.25), 150rpm avoids light and stirs 25min;

[0060] (3) Add 0.3mL 1,3,5-trimethylbenzene (TMB) solution while shaking in a water bath ultrasonic (4kHz) ...

Embodiment 3

[0063] Example 3 Manganese-mesoporous polydopamine nanoparticles prepared by doping before polymerization

[0064] (1) 105mg dopamine hydrochloride and 3mg manganese sulfate hydrate are dissolved in 4.5mg ultrapure water (the mass ratio of dopamine hydrochloride and manganese sulfate hydrate is 35:1; the mass volume ratio of manganese sulfate hydrate and ultrapure water is 1mg:1.5 mL), and stirred at 200rpm in the dark for 22h to obtain manganese chelation-dopamine solution;

[0065] (2) join the 0.3mL manganese chelation-dopamine solution of 45mL surfactant F127 and step (1) in the mixed solution of 4mL ethanol and 4mL ultrapure water (the mass volume ratio of F127 and manganese chelation-dopamine solution is 150mg: 1mL, the volume ratio of ethanol, ultrapure water and manganese chelation-dopamine solution is 20:20:1.5), 150-200rpm dark stirring for 25min;

[0066] (3) Add 0.4mL 1,3,5-trimethylbenzene (TMB) solution while shaking in a water bath ultrasonic (4kHz) at 25°C, an...

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Abstract

The invention belongs to the technical field of biomedical materials, and in particular relates to a mesoporous polydopamine (MPDA) nanoparticle used for tumor T1-T2 magnetic resonance imaging. Mesoporous polydopamine nanoparticles with imaging effects. The present invention adopts a doping method before polymerization, uses dopamine hydrochloride and Mn precursors as basic raw materials, and prepares a manganese-mesoporous polydopamine nanoparticles as templates with F127 and TMB. The particle is a polydopamine nanoparticle doped with metal manganese and has a mesoporous structure. It has tumor microenvironment responsiveness, good photothermal conversion ability, and good photothermal stability; it has good biocompatibility. It can be used as both T1 and T2 contrast agent for magnetic resonance imaging of tumors.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a mesoporous polydopamine nanoparticle used for tumor T1-T2 magnetic resonance imaging. Background technique [0002] Magnetic resonance imaging (MRI) has attracted extensive attention due to its advantages of high temporal and spatial resolution, no limitation of penetration depth, and no radiation damage. Magnetic resonance contrast agents can enhance MRI signal by reducing the relaxation time of T1 or T2 water protons. T1 is called the longitudinal relaxation time, which is usually used to increase the visualization saturation and suppress the magnetic resonance signal intensity or imaging intensity. Since tissues usually have a long longitudinal relaxation time, T1-weighted images are suitable for observing adipose tissue or anatomical structures. T2 is called the transverse relaxation time, and the proton spin in the lesion usually has a longer rela...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/06C08J9/28A61K41/00A61K49/12A61K49/18A61P35/00C08L79/02
CPCC08G73/0672C08J9/286A61K49/126A61K49/1857A61K41/0052A61P35/00C08J2379/02
Inventor 曹众吴英健杨茜
Owner SUN YAT SEN UNIV
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