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Glucose electrode, micro-fluidic chip, micro-fluidic passive sweat patch, and preparation method and application of micro-fluidic passive sweat patch

A microfluidic chip and passive sweat technology, applied in the field of sensors, can solve the problems of limited extraction, sampling and chemical analysis, inability to achieve accurate fluid capture, storage, volume measurement and chemical analysis, and inconvenient use

Pending Publication Date: 2021-04-23
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional wearable sensors do not enable precise capture, storage, volumetric measurement, and chemical analysis of fluids, limiting the ability to isolate bodily fluids from contaminants and limit subsequent extraction, sampling, and chemical analysis
In addition, traditional glucose detection devices often require wounds, are inconvenient to use, cannot detect glucose in sweat, and have limited applications

Method used

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  • Glucose electrode, micro-fluidic chip, micro-fluidic passive sweat patch, and preparation method and application of micro-fluidic passive sweat patch
  • Glucose electrode, micro-fluidic chip, micro-fluidic passive sweat patch, and preparation method and application of micro-fluidic passive sweat patch
  • Glucose electrode, micro-fluidic chip, micro-fluidic passive sweat patch, and preparation method and application of micro-fluidic passive sweat patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] This embodiment provides a glucose electrode, the preparation method is as follows:

[0103] (1) Electropolymerize the aniline monomer onto the carbon ink electrode by cyclic voltammetry to obtain an electrode coated with polyaniline film; the conditions of the cyclic voltammetry include: the voltage is -0.2V-1.0V, and the cycle The number of times is 25 times, the voltage rate is 0.1V / s, the reference electrode is an Ag / AgCl electrode, and the electrolyte is a hydrochloric acid solution of aniline monomer (the concentration of aniline monomer is 0.1mol / L, and the concentration of HCl is 1mol / L);

[0104] (2) Dissolve 1% chitosan aqueous solution in 2% acetic acid aqueous solution, then mix with glucose oxidase solution (concentration is 10mg / mL, solution is PBS buffer) with the ratio of volume ratio 2:1, obtain glucose oxidase Membrane solution, drop the mixed solution on the electrode coated with polyaniline membrane, and dry at 4° C. for 12 hours to obtain the glucos...

Embodiment 2

[0106] This embodiment provides a microfluidic chip and a microfluidic passive sweat patch;

[0107] The microfluidic core includes a PDMS membrane with a microfluidic channel and an ISE sensor attached to the PDMS membrane (such as figure 1 shown) and urea test strips and pH test strips placed in the microfluidic channel (such as figure 2 Shown), wherein, ion selective sensor is made of glucose electrode (embodiment 1), Na + Electrode, K + electrode and reference electrode.

[0108] Microfluidic passive sweat patch includes double-sided adhesive layer, microfluidic chip, MPC wire layer, MPC antenna layer and electronic device layer, such as image 3 shown.

[0109] The specific preparation method of the microfluidic passive sweat patch is as follows (the preparation process is as follows: Figure 4 shown):

[0110] (1) Use oxygen plasma to activate the PDMS film and the metal-polymer conductor wire layer, and then bond the two together;

[0111] (2) Connect the electr...

Embodiment 3

[0130] The difference with Example 1 is that no chitosan is added.

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Abstract

The invention relates to a glucose electrode, a micro-fluidic chip, a micro-fluidic passive sweat patch, and a preparation method and application of the micro-fluidic passive sweat patch. The glucose electrode comprises a substrate electrode, and a polyaniline film and a glucose oxidase film which are sequentially coated on the surface of the substrate electrode. An ion-selective glucose electrode is formed by modifying an ion-selective film on the substrate electrode, passive detection of glucose in sweat is realized by utilizing the ion-selective electrode for the first time, the principle is that glucose oxidase catalyzes glucose to generate hydrogen ions, and then the hydrogen ion-selective electrode is used for detecting the generated hydrogen ions, furthermore, the glucose concentration is calculated, and no trauma is caused to a tested person. The micro-fluidic chip and a micro-fluidic passive sweat patch which are prepared from the glucose electrode have excellent performance and wide application prospect.

Description

technical field [0001] The invention relates to the technical field of sensors, in particular to a glucose electrode, a microfluidic chip, a microfluidic passive sweat patch and a preparation method and application thereof. Background technique [0002] Wearable sensors can monitor human body motion, electrophysiology, temperature and other signals in real time. With the support of technologies such as the Internet of Things, flexible sensors, and big data, wearable sensors are widely used in biomedical fields such as sports monitoring, precision medicine, and chronic disease protection. By integrating sensors into wearable products such as tattoos, patches, wristbands, watches, and clothing, a patient's physical, biological, and chemical signals can be monitored in real time. This data can be transmitted wirelessly to a data center for telemedicine systems. At present, most wearable body fluid detection is health monitoring through sweat, tears and urine. The composition...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/333G01N27/48
Inventor 蒋兴宇牟磊
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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