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Sepsis prognosis evaluation system

A prognostic evaluation and sepsis technology, applied in the field of sepsis prognostic evaluation system, can solve the problems of low sensitivity, lack of timely intervention in sepsis patients, unsatisfactory mechanical ventilation and organ function recovery, etc. Achieve high diagnostic accuracy

Pending Publication Date: 2021-04-16
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sensitivity of qSOFA prognostic evaluation is low (New Sepsis Criteria: A Change We Should Not Make. Chest2016, 149(5): 1117-1118.), resulting in many missed diagnoses, so that many patients with sepsis did not receive timely intervention in the early stage; Some scholars also pointed out that qSOFA has not been supported by critical evidence-based medical evidence, but has been misused in clinical practice to guide clinical decision-making; in addition, some studies have shown that qSOFA is not effective in evaluating mechanical ventilation and organ function recovery in patients with sepsis. (Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit. Critical care (London, England) 2017, 21(1): 73.)
[0004] At present, there is a lack of a prognostic scoring system for patients with sepsis with simple index parameters and high accuracy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 Use of the system of the present invention

[0049] The operator only needs to input the age (years), heart rate (times / minute), respiratory rate (times / minute) and whether there is disturbance of consciousness of the sepsis patient through the input module.

[0050] Disturbance of consciousness specifically refers to: the disturbance of cognition and awareness of the surrounding environment and one's own state caused by the impairment of human high-level nerve center activity, such as one of drowsiness, lethargy, light coma, moderate coma and deep coma .

[0051] The scoring module of the system of the present invention will score according to the following criteria:

[0052] The scoring module receives information from the input module, and scores according to the PPS rule of the present invention:

[0053] 1) Age: 71 years old, 5 points;

[0054] 2) Heart rate: 123 beats / min, 3 points;

[0055] 3) Respiratory frequency: 25 breaths / minute, 6 points; ...

experiment example 1

[0080] Experimental example 1 The ability of the present invention to assess the prognosis of patients with low, medium and high risk sepsis

[0081] 1. Method

[0082] Use the prognosis evaluation system of the present invention to carry out scoring to research object, research object is divided into low-risk group (PPS: 0-6 point, n=79), middle-risk group (PPS: 7-9 point, n=79), High-risk group (PPS: 10 points and above, n=78).

[0083] The 28-day mortality rate, 7-day mortality rate, 28-day mechanical ventilation rate, and 28-day ICU admission rate of the low-risk group, medium-risk group, and high-risk group were counted.

[0084] 2. Results

[0085] The 28-day mortality rates of patients with low-risk, intermediate-risk, and high-risk sepsis were 3.8%, 13.9%, and 43.6%, respectively, and the difference was statistically significant (P<0.001); The fatality rates were 1.3%, 6.3%, and 26.9%, respectively, and the difference was statistically significant (P<0.001); the 28-...

experiment example 2

[0086] Experimental example 2 Scoring rule PPS effectiveness evaluation of the present invention

[0087] 1. Method

[0088] 1.1 Accuracy:

[0089] A goodness-of-fit test was used to compare the expected frequency of the PPS score with the observed frequency of the distribution to determine whether there was a significant difference between the two.

[0090] The basic idea of ​​the goodness of fit test here is as follows:

[0091] 1) Group the subjects according to the PPS score, and sort the groups according to the PPS score from small to large, and divide them into 10 small Group ;

[0092] 2) Calculate the expected frequency and observed frequency in each group respectively, the expected frequency is the test group for each group The sum of the frequencies of terminal events occurring in each group, and the observation frequency is the sum of the frequencies of terminal events occurring in each group in the verification group;

[0093] 3) Calculate the chi-square ...

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Abstract

The invention provides a sepsis prognosis evaluation system. The system is used for carrying out pre-hospital prognosis evaluation on sepsis according to information such as age, heart rate, respiratory rate, existence of consciousness disturbance and the like. The 7-day case fatality rate, the 28-day case fatality rate, the 28-day mechanical ventilation rate and the 28-day ICU occupancy rate of sepsis patients graded by the system have significant differences. The evaluation system provided by the invention can quickly and accurately guide sepsis risk grading, and has a very good application prospect.

Description

technical field [0001] The invention belongs to the field of pre-hospital prognosis assessment of diseases, in particular to a sepsis prognosis assessment system. Background technique [0002] Sepsis is a clinical syndrome in which the dysregulated host response to infection causes life-threatening organ dysfunction, and its mortality rate is high and its incidence rate is increasing year by year. Among the 750 million hospitalized patients in the United States from 1979 to 2000, there were 10,319,418 cases of sepsis, and the annual incidence increased from 164,000 cases to 660,000 cases, with an annual growth rate of 9%. The fatality rate of sepsis is between 30% and 50%. With the improvement of medical staff's awareness of sepsis, the fatality rate of sepsis has declined in recent years. However, since the early clinical manifestations of sepsis are not specific, multiple organ systems are involved. Because sepsis patients have great individual differences, if the develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/50
Inventor 曹钰李东泽姚蓉王婉婷何亚荣
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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