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Pen injector borosilicate glass sleeve injection box and methotrexate injection packaged by the same

A technology of methotrexate and cartridges, applied in the direction of syringes, ampoule syringes, hypodermic injection equipment, etc., which can solve the problems of low concentration in target tissues, physical injury of children, and short plasma half-life, so as to avoid waste and reduce labor Intensity, the effect of avoiding side effects

Active Publication Date: 2021-04-06
HUNAN HUIZE BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pharmacokinetic parameters reported in the literature, including peak concentration, peak time, area under the plasma concentration-time curve, and individual differences are between 30 and 90%. MTX is excreted by the kidneys in a short time after a large amount of administration, resulting in 5 ~8h short plasma half-life, low concentration in target tissues
The existing conventional preparations are injections and tablets, which have strong toxic and side effects such as gastrointestinal reactions, bone marrow suppression, and liver and kidney toxicity.
Especially in the process of administering methotrexate to children, the consequences of side effects caused by inaccurate dosing can be serious for children's physical damage

Method used

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  • Pen injector borosilicate glass sleeve injection box and methotrexate injection packaged by the same
  • Pen injector borosilicate glass sleeve injection box and methotrexate injection packaged by the same
  • Pen injector borosilicate glass sleeve injection box and methotrexate injection packaged by the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The existing cartridge injection pens perform quantitative determination by rotating the parts at the end of the pen. For example, when the user does not grasp the injection volume accurately, the quantitative inaccuracy is prone to occur. In addition, during the use of the existing cartridge injection pen, the movable plastic stopper in the cartridge is easy to spring back, resulting in inaccurate measurement. In response to these shortcomings, the injection pen is specially improved, especially the quantitative method is improved to avoid the side effects caused by the overdose injection of methotrexate, and it can also ensure the multiple use of the injection in the cartridge and avoid the loss of the drug solution. waste.

[0062] like figure 1 As shown, the present invention provides a cartridge injection box for packaging methotrexate injection, comprising an injection box shell and an injection box body connected by a rotating shaft; an injection pen is placed i...

Embodiment 2

[0092] The difference from Example 1 is that the elastic component includes an elastic storage chamber and a pressing elastic piece; the pressing elastic piece itself is elastic, and is stored in the elastic storage cavity under the action of external pressure, and automatically resets after the external pressure disappears ; One end of the pressing elastic member is fixedly arranged in the lower end of the elastic storage cavity, and the other end is away from the elastic storage cavity and has an angle of 30-60° with it; the material of the pressing elastic member can be a U-shaped stainless steel sheet or a U-shaped elastic plastic sheet .

[0093] Contents Example 1

[0094] A. Ingredient list (specification: 50mg / 2ml):

[0095]

[0096] B, the method for preparing injection:

[0097] Weigh 80% of the prescribed amount of water for injection, add the prescribed amount of methotrexate, stir and disperse evenly, and then use 1% sodium citrate solution to adjust the pH t...

Embodiment 3

[0110] A. Ingredient list (specification: 50mg / 2ml):

[0111]

[0112] B, the method for preparing injection:

[0113] Weigh 80% of the prescribed amount of water for injection, add the prescribed amount of methotrexate, stir and disperse evenly, and then use 1% sodium hydroxide / hydrochloric acid solution to adjust the pH to 8-9;

[0114] Then add mannitol and phenol, stir evenly, and add water for injection to the full amount;

[0115] Then add 0.05% activated carbon for injection for adsorption; after adsorption, the solution is first filtered by activated carbon with a 0.8um filter membrane, and then sterilized with a 0.22um microporous filter membrane;

[0116] After filtration, 2ml of the filtrate was aseptically dispensed into cartridges to obtain the finished product.

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Abstract

The invention belongs to the technical field of medicine packaging and pharmaceutical preparations, and particularly discloses a pen injector borosilicate glass sleeve injection box and a methotrexate injection packaged by the same; an injection pen is arranged in a pen injector borosilicate glass sleeve injection box body, and the injection pen comprises an injection push rod, a pen injector borosilicate glass sleeve, an injection frame, a pen injector borosilicate glass sleeve mounting sleeve and an injection needle seat part. By improving the structure of an existing injection pen, the pen injector borosilicate glass sleeve injection box of a novel structure is manufactured, injection liquid packaged by the pen injector borosilicate glass sleeve injection box not only achieves quantitative injection, but also improves injection safety, and then the purposes of reducing adverse reactions of MTX and improving the curative effect of MTX are achieved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical packaging and pharmaceutical preparations, in particular to a cartridge injection box and the methotrexate injection packaged therein. Background technique [0002] Traditional injections have been using ampoule inner packaging materials, cartridges and pen-type syringes for decades. It is a new injection method developed in recent years in which patients can independently use injections for multiple times. It has been widely used. Applied to insulin injection products, compared with ampoule bottle injection products, cartridge bottle pen injection products have the following advantages: (1) There is no need to perform irregular destructive opening treatment on the medicine bottle during use, so as to prevent breakage Part of the glass debris produced enters the liquid medicine, and enters the human body along with the liquid medicine to cause harm to the human body. (2) It can avoid the u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/00A61M5/24A61M5/31A61K9/08A61K31/519A61K47/02A61K47/12A61P35/00A61P35/02
CPCA61K31/519A61K9/08A61K9/0019A61K47/12A61K47/02A61P35/00A61P35/02A61M5/002A61M5/24A61M5/31
Inventor 周群黄建国罗熙
Owner HUNAN HUIZE BIO PHARMA CO LTD
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