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Eye drops containing olopatadine hydrochloride and preparation method of eye drops

A technology of olopatadine hydrochloride and eye drops, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, which can solve the problems of dry eyes, sodium hyaluronate, etc. Unstable, easy to be polluted and long-term bacteria, etc., to reduce the occurrence of complications and sequelae, relieve dry eyes, and relieve eye fatigue

Inactive Publication Date: 2021-04-06
苏州工业园区天龙制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing eye drops have general effects during use, such as eye drops containing sodium hyaluronate. Sodium hyaluronate is unstable under light and heat and is easy to degrade. It is not suitable for long-term storage at room temperature. At the same time, hyaluronate Sodium is a kind of biological macromolecule mucopolysaccharide, which is easy to be polluted and grow bacteria, so that its stability and moisturizing effect are average, and it cannot relieve dry eyes. Therefore, we propose a olopatadine hydrochloride Eye drops and preparation method thereof

Method used

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  • Eye drops containing olopatadine hydrochloride and preparation method of eye drops

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Experimental program
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Embodiment 1

[0027] Please refer to figure 1 As shown, the invention discloses an eye drop containing olopatadine hydrochloride, comprising the following raw materials in parts by weight: 0.3 parts of olopatadine hydrochloride, 0.3 parts of hypromellose, 0.4 parts of bacteriostatic agent, 0.1 part of thickener, 0.4 part of pH regulator, 0.7 part of osmotic pressure regulator, 0.6 part of water-soluble antioxidant and 80 parts of water for injection.

[0028] A preparation method of eye drops containing olopatadine hydrochloride, comprising the following steps:

[0029] S1. Preparation of mixed solution 1: Weigh the required olopatadine hydrochloride in parts by weight, put it into a container, and add an appropriate amount of water for injection to dissolve to obtain mixed solution 1, which is set aside;

[0030] S2. Preparation of mixed solution 2: Weigh the required hypromellose, bacteriostat and thickener in parts by weight and put them into the liquid mixing tank. The thickener is pol...

Embodiment 2

[0036] Please refer to figure 1 As shown, the invention discloses an eye drop containing olopatadine hydrochloride, comprising the following raw materials in parts by weight: 0.45 parts of olopatadine hydrochloride, 2.2 parts of hypromellose, 0.5 parts of bacteriostatic agent, 0.2 part of thickener, 0.5 part of pH regulator, 0.8 part of osmotic pressure regulator, 0.67 part of water-soluble antioxidant and 90 parts of water for injection.

[0037] A preparation method of eye drops containing olopatadine hydrochloride, comprising the following steps:

[0038] S1. Preparation of mixed solution 1: Weigh the required olopatadine hydrochloride in parts by weight, put it into a container, and add an appropriate amount of water for injection to dissolve to obtain mixed solution 1, which is set aside;

[0039] S2. Preparation of mixed solution 2: Weigh the required hypromellose, bacteriostatic agent and thickener in parts by weight and put them into the liquid mixing tank. The thicke...

Embodiment 3

[0045] Please refer to figure 1 As shown, the invention discloses an eye drop containing olopatadine hydrochloride, comprising the following raw materials in parts by weight: 0.6 part of olopatadine hydrochloride, 0.5 part of hypromellose, 0.7 part of bacteriostatic agent, 0.3 part of thickener, 0.6 part of pH regulator, 0.9 part of osmotic pressure regulator, 0.7 part of water-soluble antioxidant and 96 parts of water for injection.

[0046] A preparation method of eye drops containing olopatadine hydrochloride, comprising the following steps:

[0047] S1. Preparation of mixed solution 1: Weigh the required olopatadine hydrochloride in parts by weight, put it into a container, and add an appropriate amount of water for injection to dissolve to obtain mixed solution 1, which is set aside;

[0048] S2. Preparation of mixed solution 2: Weigh the required hypromellose, bacteriostat and thickener in parts by weight and put them into the liquid mixing tank. The thickener is chitos...

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Abstract

The invention discloses eye drops containing olopatadine hydrochloride and a preparation method of the eye drops, and relates to the technical field of eye drops. The eye drops contain the following raw materials in parts by weight: 0.3 to 0.6 part of olopatadine hydrochloride, 0.3 to 0.5 part of hydroxypropyl methylcellulose, 0.4 to 0.7 part of a bacteriostatic agent, 0.1 to 0.3 part of a thickening agent, 0.4 to 0.6 part of a pH regulator, 0.7 to 0.9 part of an osmotic pressure regulator, 0.6 to 0.7 part of a water-soluble antioxidant and 80 to 96 parts of water for injection. According to the invention, the water-soluble antioxidant is added, so the risks of eye dryness, infection and the like are reduced, eye fatigue is relieved, the eye drops can be used for safely and efficiently treating eye inflammatory diseases, a certain dosage of thickener is added, the comfort of a medicine can be obviously improved, the safety of the eye drops is improved, and the dry eyes are alleviated in a better way; the eye drops disclosed by the invention are small in dosage, free of preservatives and few in side effects on the whole body, can be directly absorbed in eyes, can be quickly absorbed to focus parts, and can quickly play a role in treatment.

Description

technical field [0001] The invention relates to the technical field of eye drop preparation, in particular to an eye drop containing olopatadine hydrochloride and a preparation method thereof. Background technique [0002] The main treatment for dry eye disease is to supplement tears, that is, to use artificial tears locally to improve the humidity and lubrication ability of the eye surface. Abnormal volume or dynamics, leading to decreased tear film stability, accompanied by eye discomfort and (or) ocular surface tissue lesions characteristics of a variety of diseases. In recent years, as TV dramas and computers are widely used in human daily life, the aging population is gradually increasing, and the incidence of dry eye disease is increasing year by year, which seriously affects the normal development of vision of teenagers and the eye health of middle-aged and elderly people. Therefore, drip Eye drops play an important role in people's lives. [0003] Existing eye drop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/36A61K47/32A61K31/335A61P27/02
CPCA61K9/08A61K9/0048A61K47/36A61K47/32A61K31/335A61P27/02
Inventor 陈业仓
Owner 苏州工业园区天龙制药有限公司
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