Breast cancer prognosis marker and application

Abstract

The invention discloses a breast cancer prognosis evaluating marker and application, and belongs to the technical field of biology. The invention aims to find a marker for effectively evaluating breast cancer prognosis. TCGA, GEO and DNA methylation data of the whole genome level autonomously generated based on a sequencing technology are integrated, it is revealed that the tumor center is in a hypoxic state compared with the tumor edge, survival analysis finds that the HR of a CpG site cg15190451 is smaller than 1, it shows that the breast cancer progress risk is reduced along with increase of the methylation level, and the higher the level is, the patient prognosis is better; and it is prompted that the breast cancer prognosis effect can be judged according to the methylation level of the gene SLC16A5 where cg15190451 is located. The breast cancer prognostic marker is obtained by verifying hypoxia markers in an HER2 positive breast cancer sample on the basis of the expression level of SLC16A5, the breast cancer prognostic evaluation efficiency can be improved, the cost is saved, and the marker is suitable for popularization and application and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a prognostic marker and application of breast cancer. Background technique [0002] In the United States, 12 percent of women will be diagnosed with breast cancer in their lifetime, and more than 250,000 new breast cancer cases were diagnosed in the United States in 2017. Breast cancer can be divided into 3 main subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly known as HER2): Hormone receptor positive / ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), triple negative (tumor lacks all 3 standard molecular markers; 15%). More than 90% of breast cancers are not metastatic at the time of diagnosis. For patients without metastatic disease, the goals of treatment are tumor eradication and prevention of recurrence. Triple-negative breast cancer is more likely to ...

AI Technical Summary

Problems solved by technology

However, the prognostic significance of FOXP3+ tumor-infiltrating lymphocytes (TILs) in breast cancer remains controversial

Although polygenic assays function at the molecular level with the aim of providing patient risk stratification and prediction of treatment response, the place of polygenic assays in clinical practice is not yet stable

The key issues are the inconsistent level of evidence related to the interpretation of patient prognosis and the difficulty of testing results, which hinders its widespread clinical application

Among them, breast cancer prognosis research uses breast cancer MRI images to predict ki67 scores, and ki67 scores can be used as an indicator of breast cancer prognosis, but MRI images are still controversial as a clinical predictor of prognosis

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