Medical cationic polymer antimicrobial dressing and preparation method

Abstract

The invention relates to a medical cationic polymer antimicrobial dressing and a preparation method. The antimicrobial dressing is a polymer including polyhexamethylene guanide hydrochloride, chitosanand polyvinyl alcohol, and the antibacterial dressing comprises the following components in parts by weight: 1-5 parts of chitosan, 0.05-0.4 part of polyhexamethylene guanide hydrochloride and 0.05-0.75 part of polyvinyl alcohol. The antimicrobial dressing has the beneficial effects that the long-chain guanidine polyhexamethylene guanide hydrochloride and the polymer chitosan are selected to synergistically exert the antimicrobial ability, and the dressing is processed by utilizing good mechanical properties of the long-chain guanidine polyhexamethylene guanide hydrochloride and the polymer chitosan; the antimicrobial dressing is not prone to fall off, is not prone to enter the human body, and a 3D porous spongy dressing can be prepared, so that the dressing has good water absorption andmoisture retention properties; and the antimicrobial dressing can have a local broad-spectrum antimicrobial property, is not prone to develop drug resistance, has low toxicity, has a good effect of promoting wound healing, provides a mechanical protection effect for a wound, absorbs exudates, keeps the wound moist and has high biocompatibility, and the drug is not prone to enter blood.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a cationic polymer medical antibacterial dressing and a preparation method thereof. Background technique [0002] Wound infection can cause a variety of serious complications, such as sepsis, multiple organ failure, etc. Topical application of antibacterial dressings is currently one of the main methods for preventing and treating infected wounds. Antibacterial dressings are classified according to their effective antibacterial components. Current research hotspots include antibiotics, nano-metal particles, and polymers. [0003] There are thousands of antibiotics that have been discovered, but those that can be used systemically are very limited. Antibiotics act on specific targets of bacteria and are prone to drug resistance; local administration still has the risk of toxicity, entering the body, and developing drug resistance. Nano-metal particles are representative of...

AI Technical Summary

Problems solved by technology

However, short-chain guanidinium salt wounds will be endocytosed by mammalian cells, leading to the accumulation of local antibacterial agents. After endocytosis, it may lead to rejection of the body, local inflammatory reactions, resulting in local pigmentation, or allergic reactions; small molecule antibacterial agents are mainly used , the release is too fast, and the antibacterial persistence is not strong; salts are difficult to process, uncertain, and there is still a risk of entering the circulatory system and reaching sensitive organs when used on wounds

[0005] The previous medical guanidine antibacterial agent dressings loaded small molecule guanidine salts through simple physical soaking method or directly applied guanidine liquid dressings to release antibacterial agents on the wound surface. Endocytosis by human cells, there is a risk of toxic side effects

[0006] At present, researchers are trying to prepare medical wound dressings by loading antibacterial agents in various ways. PHMG meets the requirements of broad-spectrum antibacterial properties and low toxicity, but antibacterial dressings still need good water absorption and moisturizing properties and wound protection properties, and are usually made into sponges. However, finding reasonable material components and preparation methods to prepare antibacterial dressings with good performance also requires further research and experiments.

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