Sample pretreatment device

A technology of pretreatment device and cleaning liquid, which is applied to spray devices, measuring devices, spray devices, etc., can solve problems such as easy clogging of nozzles 30, and achieve the effects of unblocking, high-substrate coating, and impact suppression.

Pending Publication Date: 2021-03-12
SHIMADZU SEISAKUSHO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is a problem that a crystal block of the matrix substance is easily formed near the front end of the nozzle 30, whereby the nozzle 30 is easily clogged.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0082] Next, an example of an experiment performed to confirm the cleaning effect of the cleaning unit 4 on the nozzle 30 used in the substrate spraying device will be described.

[0083] According to the mechanism of the spraying of the matrix solution in this device, the matrix solution must adhere to the front end of the needle 31 in the spraying part 3, and the solvent in the solution is vaporized, thus it is inevitable that the matrix substance is deposited on the surface of the needle 31. . The higher the concentration of the matrix substance in the matrix solution, the more pronounced this phenomenon is. In addition, the degree of clogging also varies depending on the type of matrix substance. Therefore, in this experimental example, a high-concentration matrix solution was prepared using 9-Aminoacridine (9-aminoacridine, hereinafter abbreviated as "9-AA"), which is a matrix that is relatively easy to clog, and sprayed to remove The matrix is ​​intentionally deposited...

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Abstract

The present invention provides a sample pretreatment device capable of accurately and efficiently removing nozzle clogging caused by precipitation of crystals of a matrix material. Provided is a sample pretreatment device configured to apply, to the surface of a sample, a solution in which a predetermined substance is dissolved or dispersed. In order to properly and efficiently unclog a nozzle dueto the deposition of the crystal of a matrix substance, the device includes a spray unit (3) including a solution tube (32) for the solution to pass through, a gas tube (33) for a spray gas to pass through, and a nozzle part (30) configured to spray the solution arriving at the terminal end of the solution tube by ejection of the spray gas through the gas tube, as well as a cleaning liquid supplier (4, 41) configured to put a cleaning liquid on an opening of the nozzle part from outside the spray unit.

Description

technical field [0001] The present invention relates to a sample pretreatment device for performing pretreatment when analyzing the sample by applying a predetermined solution or forming a film of a predetermined substance on the surface of the sample. Background technique [0002] In recent years, an imaging mass spectrometer using a matrix-assisted laser desorption ionization (MALDI=Matrix Assisted Laser Desorption Ionization) method as an ionization method has been developed. In an imaging mass spectrometer, for example, the distribution of a substance having a specific mass can be investigated based on the results of mass spectrometry at a plurality of measurement points in a two-dimensional region on a sample such as a biological tissue slice. [0003] In order to perform mass spectrometry analysis on a sample using such an apparatus, it is necessary to perform sample pretreatment in which a matrix for MALDI (hereinafter, simply referred to as "matrix") is thinly attach...

Claims

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Application Information

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IPC IPC(8): G01N1/28G01N1/34G01N27/62
CPCG01N1/28G01N1/34G01N27/62G01N2001/317G01N1/31G01N35/1004B05B15/555B05B9/0413B05B1/265B05B7/067B05B7/2494B05B12/006H01J49/164H01J49/0418B05B15/5223H01J49/0445H01J49/165
Inventor 高桥和辉寺岛健太
Owner SHIMADZU SEISAKUSHO CO LTD
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