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Alveolar macrophage-like multifunctional nanoparticle loaded with aggregation-induced emission photothermal material and preparation method and use of alveolar macrophage-like multifunctional nanoparticle

A technology of alveolar macrophages, aggregated luminescence, applied in the field of biomedicine, can solve the problem of lack of new coronary pneumonia biomimetic nano-platform

Pending Publication Date: 2021-03-05
THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Cell membrane-encapsulated nanoparticles (NPs), as an effective biomimetic nano-platform, have unique advantages in the treatment of certain diseases, such as tumors, Sepsis and HIV, etc.; Existing technology lacks effective biomimetic nanoplatforms for COVID-19

Method used

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  • Alveolar macrophage-like multifunctional nanoparticle loaded with aggregation-induced emission photothermal material and preparation method and use of alveolar macrophage-like multifunctional nanoparticle
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  • Alveolar macrophage-like multifunctional nanoparticle loaded with aggregation-induced emission photothermal material and preparation method and use of alveolar macrophage-like multifunctional nanoparticle

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Embodiment 1

[0038] Example 1 Synthesis of aggregated luminescent photothermal material 2TPE-2NDTA

[0039] The synthesis steps of the aggregated luminescent photothermal material 2TPE-2NDTA refer to the existing technology, and the specific synthesis route is as follows figure 2 shown.

Embodiment 2

[0040] Example 2 Preparation of TN@AM NPs multifunctional nanoparticles

[0041] Dissolve 10.0mg of polylactic / glycolic acid copolymer (Polylacticcoglycollic Acid, PLGA) in 1mL of tetrahydrofuran (THF) solution, then add 1.0mg of aggregated light-emitting photothermal material 2TPE-2NDTA to it, mix it evenly, and use a 1ml syringe Quickly inject 3mL of Milli-Q ultrapure water (Millipore, USA) rotating at high speed, and then stir in the dark (300-500rpm, temperature 4-25°C, time 4-48h) to remove THF in the mixture solvent. Use a syringe filter with a pore size of 0.22 μm to remove large particles, and then use a 10KDa ultrafiltration tube to ultrafilter and wash multiple times to wash away all unassembled free 2TPE-2NDTA, and to remove unbound 2TPE-2NDTA and Polylactic acid / glycolic acid copolymer (PLGA), that is, 2TPE-2NDTA core.

[0042] Mix the 2TPE-2NDTA nucleus with the alveolar macrophage membrane, and ultrasonicate in a water bath (power 50W-100W, temperature 4-25°C, ...

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Abstract

The invention belongs to the field of biological medicines and discloses an alveolar macrophage-like multifunctional nanoparticle loaded with an aggregation-induced emission photothermal material anda preparation method and use of the alveolar macrophage-like multifunctional nanoparticle. The nanoparticle is obtained by taking an aggregation-induced emission photosensitive molecule 2TPE-2NDTA anda polylactic acid / glycollic acid copolymer as a co-carrier to form a core of a nano-drug and coating the 2TPE-2NDTA and the polylactic acid / glycollic acid copolymer with an alveolar macrophage membrane through a design and synthesis. The nanoparticle also has a characteristics of a photo-thermal agent and can be excited by near-infrared laser, and generated heat is used for photo-thermal killingof novel coronaviruses. Meanwhile, since the alveolar macrophage membrane on an outer layer of a nano-drug has related receptors on a surface, the nano-drug can adsorb SARS-CoV-2 and cytokines, so that a purpose of resisting a cytokine storm is achieved. The alveolar macrophage-like multifunctional nanoparticle can also solve a disadvantage and a deficiency of a poor curative effect in a traditional antiviral treatment scheme and becomes a new antiviral treatment strategy.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, and more specifically, relates to an alveolar macrophage-like multifunctional nanoparticle loaded with aggregated luminescent photothermal material and its preparation method and application. Background technique [0002] The outbreak of the novel coronavirus has triggered a global public health crisis due to its strong transmission ability and high mortality rate. Although a variety of drugs and vaccines have been put into clinical trials around the world, there is still no specific drug or solution for the treatment of new coronary pneumonia. Finding new drugs requires a clear understanding of the underlying molecular mechanisms of viral infection and their established efficacy, as well as long-term assessment of potential toxicity, which is a long-term and arduous task for highly transmissible viruses such as SARS-CoV-2 . In addition, current antiviral drugs usually only target a...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/46A61K47/34A61K41/00A61P31/14
CPCA61K9/5176A61K9/5192A61K9/5153A61K41/0052A61P31/14
Inventor 黄曦李斌王伟唐本忠
Owner THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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