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Marine oligosaccharide-containing antifungal infection composition for pets

A technology of marine oligosaccharides and antifungal drugs, which is applied in the directions of medical preparations containing active ingredients, antifungal agents, organic active ingredients, etc., to achieve the effects of increasing efficiency, reducing drug resistance, and reducing adverse reactions

Inactive Publication Date: 2021-03-02
QINGDAO BZ OLIGO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Guluronic acid oligosaccharides, as a series of active ingredients extracted from brown algae series plants, have antimicrobial, anti-oxidation, anti-aging, anti-inflammatory, and neuroprotective activities, but they have not been seen as antifungal drug synergists Reports on combined use of antimicrobial drugs in the treatment of fungal diseases

Method used

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  • Marine oligosaccharide-containing antifungal infection composition for pets
  • Marine oligosaccharide-containing antifungal infection composition for pets
  • Marine oligosaccharide-containing antifungal infection composition for pets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Pharmacological test: the influence of guluronic acid oligosaccharides on the growth of different fungi

[0023] Observe the inhibitory effects on the growth of different fungi under the conditions of 0%, 2%, 6%, and 10% guluronic acid oligosaccharides. The observation results of different concentrations of guluronic acid oligosaccharides on the fungal cell density are shown in the figure; the observation results of different concentrations of guluronic acid oligosaccharides on the growth of fungal mycelium are shown in figure 2 .

[0024] The inventors of the present invention found that guluronic acid oligosaccharides have a certain inhibitory effect on the growth of various fungi in a concentration-dependent manner. The inhibitory effect was most pronounced in the presence of 10% guluronic acid oligosaccharides, with a 15-50% decrease in cell density. In addition, at the same concentration, the inhibitory effect on different fungi is also different, a...

Embodiment 2

[0025] Example 2 Effects of guluronic acid oligosaccharides and antifungal drugs on different fungal strains

[0026] 1. Materials and methods

[0027] 1. Experimental strains

[0028] Candida albicans ATCC 90028, Candida glabrata ATCC2001, Candida tropicalis 519468, Candida lusitaniae994 / 01(2), Candida krusei All were purchased from the American Type Culture Collection (ATCC); Aspergillus niger, Aspergillus flavus, and Aspergillus fumigatus were isolated and extracted from moldy fruits by our laboratory. All strains had been identified morphologically and molecularly, and All the strains were activated on sandcastle dextrose agar (SDA) medium, and single clones were selected for activation again. The single clones obtained for the second time were placed on the SDA slant, cultivated by the above method, and stored at 4°C for future use.

[0029] 2. Preparation of guluronic acid oligosaccharides and antifungal drugs

[0030] Guluronic acid oligosaccharides: self-made by the...

Embodiment 3

[0044] Example 3 Clinical efficacy evaluation of the pet synergist of the present invention

[0045] 1 test article

[0046] 1.1 Test drugs:

[0047] Self-made 6% guluronic acid oligosaccharide solution and commercially available nystatin glycerin ointment.

[0048] 1.2 Test animals:

[0049] 6 Beagle dogs were selected from a certain dog breeding base in Qingdao City, Shandong Province. Cases diagnosed as canine fungal dermatosis, the clinical manifestations are ringworm, hair loss, dander, etc., accompanied by local papules, pustules, or erythematous depilatory spots or nodules.

[0050] 2 test steps

[0051] 90 cases of naturally infected dogs were randomly divided into 3 groups, 30 dogs in each group. The affected part of the sick dog was clipped to remove dirt such as scabs and dander, and local skin medication was applied to the affected part, twice a day, for 14 consecutive days, and the drug was stopped. 2 days, and then the next course of treatment for 14 days, a...

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Abstract

The invention provides a marine oligosaccharide-containing antifungal infection composition for pets, and belongs to the technical field of animal medicines. The invention opens up a new application of guluronic acid oligosaccharide, and the guluronic acid oligosaccharide serving as a synergist of antifungal drugs for pets can reduce the dosage of antifungal drugs such as azoles, polyenes and thelike, so that the toxic and side effects of the drugs, especially fluconazole, nystatin, amphotericin B and the like, are reduced. Especially, the guluronic acid oligosaccharide serves as a synergistof the antifungal drug for pets, so that the antifungal drug recovers the effect on drug-resistant fungi, pet fungal infection, especially drug-resistant fungal infection, is effectively treated, thetoxicity of the drug is reduced, the economic burden of pet medication is relieved, and the guluronic acid oligosaccharide has important feeding application value.

Description

technical field [0001] The invention belongs to the technical field of animal medicine, and in particular relates to an antifungal infection composition for pets containing marine oligosaccharides. Background technique [0002] Fungi are a class of microorganisms that exist widely in nature, some of which can parasitize on the surface of dogs and cats, causing fungal skin diseases. The main clinical manifestations are local or systemic depilation and desquamation, and secondary bacterial infection can form pyogenic infections. The disease mostly occurs in young dogs, cats, and dogs and cats with weak constitution, reduced body resistance and old age. With the improvement of people's living standards, the number of pets (dogs and cats) has increased sharply, and because big cat dermatophytosis is a common zoonotic disease, it is related to the health of humans and dogs and cats, so it has attracted people's attention and attention. [0003] At present, the commonly used an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61K31/715A61K45/06A61P31/10
CPCA61K31/702A61K31/715A61K45/06A61P31/10A61K2300/00
Inventor 徐小龙张斌管昶王丽丽张娜娜高芹芹
Owner QINGDAO BZ OLIGO BIOTECH
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