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Application of chalcone compound in the preparation of medicine for improving sleep

A technology for improving sleep and compounds, applied in the field of biomedicine, can solve problems such as dependence and drug resistance, and achieve the effects of good synergy, good safety, and good hypnotic effect.

Active Publication Date: 2021-09-21
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs act quickly and have a clear mechanism of action, but long-term use is accompanied by the disadvantages of drug resistance and dependence

Method used

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  • Application of chalcone compound in the preparation of medicine for improving sleep
  • Application of chalcone compound in the preparation of medicine for improving sleep
  • Application of chalcone compound in the preparation of medicine for improving sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0066] method:

[0067] 1. Isolation and identification of new chalcone compounds

[0068] 1.1 Experimental equipment

[0069] Nicolet-510P infrared spectrometer (USA), v max in cm -1 The unit is Bruker AMX-400 nuclear magnetic resonance instrument, TMS is the internal standard, the chemical shift is expressed in δ, and the coupling constant is expressed in J.

[0070] 1.2 Extraction and separation methods

[0071] 3.4kg of ranunculus thorns were crushed, leached with 10L ethanol at room temperature, the filtrate was filtered, and concentrated under reduced pressure to obtain 6.5g of the total extract. The total extract was separated by silica gel column chromatography, and the gradient elution of the n-hexane / ethyl acetate system was followed by a mixture of n-hexane / ethyl acetate volume ratios of 10:90, 7.5:92.5 and 5:95. Solvent was eluted to obtain 8 components (F1-8), wherein, component F3 (120 mg) was subjected to repeated silica gel chromatography (1.8:8.2, v / v) in...

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PUM

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Abstract

The invention provides the application of chalcone compounds in the preparation of sleep-improving medicines, belonging to the technical field of biomedicine. The present invention provides a chalcone compound 4-Benzyloxylonchocarpin isolated from Buttercup thorn, which has been proved by experiments to have good hypnotic effect and good safety, and can increase the most important inhibitory nerve in the central nervous system. Transmitter GABA level, and it has a good synergistic hypnotic effect with chloral hydrate, so the chalcone compound 4-Benzyloxylonchocarpin of the present invention has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of chalcone compounds in the preparation of sleep-improving medicines. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Sleep is an active physiological process of the human body, which can restore energy and relieve fatigue. Sleep accounts for 1 / 3 of human life, and adequate sleep is the basis for ensuring normal life; studies have shown that lack of sleep is negatively correlated with well-being; at the same time, people with poor sleep quality and short sleep time suffer from cardiovascular disease, hypertension, The risk of diseases such as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61K31/047A61K45/06A61P25/20C07D311/72
CPCA61K31/047A61K31/353A61K45/06A61P25/20C07D311/72A61K2300/00
Inventor 吕翠王岱杰崔莉张宇张浩武玉波谢惠冯彦祥
Owner SHANDONG ANALYSIS & TEST CENT
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