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Sodium azulene sulfonate compound mouthwash and preparation method thereof

A technology of sodium azulene sulfonate and solution, which is applied in the field of sodium azulene sulfonate compound gargle and its preparation, and can solve the problems of unstable chemical properties of sodium azulene sulfonate, changes in product appearance and color, and easy removal of sulfonic acid groups, etc. problems, to achieve the effects of not easy to decompose, long validity period, and increase solubility

Active Publication Date: 2021-02-26
北京华素制药股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many mouthwash products containing sodium azulene sulfonate on the market, but we have found through research that although sodium azulene sulfonate is applied to mouthwash with the effect of repairing oral mucosa, it is more effective in preventing and treating oral ulcers. Good effect, but the chemical properties of sodium azulene sulfonate are unstable, it will be decomposed by light, air oxidation and high temperature, and it is easy to remove the sulfonic acid group
Mouthwash products containing sodium azulene sulfonate currently on the market generally have problems such as color changes in appearance and content decline due to the decomposition of sodium azulene sulfonate

Method used

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  • Sodium azulene sulfonate compound mouthwash and preparation method thereof
  • Sodium azulene sulfonate compound mouthwash and preparation method thereof
  • Sodium azulene sulfonate compound mouthwash and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment one (taking preparation 100kg as example):

[0044]

[0045] Preparation:

[0046] Step 1: Warm up deionized water to 85 degrees, add sorbitol, sodium saccharin, cetylpyridinium chloride (CPC), chlorhexidine gluconate with 20% mass fraction, stir for 20 minutes, and keep warm for 30 minutes as the first configuration solution;

[0047] Step 2: Cool down the temperature of the first configuration solution to 40 degrees, add poloxamer 407, potassium sorbate, propylene glycol, menthol, menthane carboxamide, and mint essence, and stir for 20 minutes;

[0048] Step 3: adding sodium azulene sulfonate (SAS) and citric acid, stirring for 20 minutes, and filtering out after passing the test.

Embodiment 2

[0049] Embodiment two (taking preparation 100kg as example):

[0050]

[0051] Preparation:

[0052] Step 1: Warm up deionized water to 85 degrees, add sorbitol, sodium saccharin, cetylpyridinium chloride (CPC), domiphene, stir for 20 minutes, keep warm for 30 minutes, as the first configuration solution;

[0053] Step 2: Cool the first configuration solution to 40 degrees, add hydrogenated castor oil, methylparaben, 95% ethanol by mass fraction, menthane carboxyethylamide, and the essence of orange fragrance, and stir for 20 minutes;

[0054] Step 3: adding sodium azulene sulfonate (SAS) and citric acid, stirring for 20 minutes, and filtering out after passing the test.

Embodiment 3

[0055] Embodiment three (taking preparation 100kg as example):

[0056]

[0057]

[0058] Preparation:

[0059] Step 1: Warm up deionized water to 85 degrees, add sorbitol, sodium saccharin, cetylpyridinium chloride (CPC), chlorhexidine gluconate with 20% mass fraction, stir for 20 minutes, and keep warm for 30 minutes as the first configuration solution;

[0060] Step 2: Cool the first configuration solution to 40 degrees, add hydrogenated castor oil, sodium benzoate, ethanol with a mass fraction of 95%, menthol, and the essence of sea mint, and stir for 20 minutes;

[0061] Step 3: adding sodium azulene sulfonate (SAS) and citric acid, stirring for 20 minutes, and filtering out after passing the test.

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Abstract

The invention discloses sodium azulene sulfonate compound mouthwash. The sodium azulene sulfonate compound mouthwash is prepared from the following raw materials in percentage by mass: 0.03 to 3 percent of an antibacterial agent, 0.003 to 0.3 percent of sodium azulene sulfonate, 0.36 to 9 percent of a solubilizer, 0.008 to 15 percent of a sweetener, 0.005 to 2 percent of a cooling agent, 0.005 to0.3 percent of cetylpyridinium chloride, 0.03 to 3 percent of a preservative, 0 to 5 percent of ethanol, 0 to 0.1 percent of a pH (potential of Hydrogen) regulator and the balance de-ionized water, wherein the antibacterial agent is domiphen bromide or chlorhexidine gluconate. The invention further discloses a preparation method of the sodium azulene sulfonate compound mouthwash. The sodium azulene sulfonate compound mouthwash provided by the invention has high product stability and long effective period.

Description

technical field [0001] The invention relates to the technical field of oral care products, in particular to a sodium azulene sulfonate compound gargle and a preparation method thereof. Background technique [0002] Common oral cleaning products include toothpaste, mouth cleaning mist, detergent, etc. Oral cleaning products occupy a huge market share as a necessity of life. In recent years, with people's increasing awareness of health, mouthwash, an imported product, has entered the Chinese market as a supplementary product of oral cleaning products, and has penetrated into people's oral cleaning products with a trend of increasing year by year. [0003] Sodium azulene sulfonate, also known as sodium guaiacne sulfonate, is an extract from Compositae plants (chamomile, chamomile). Many experts call it a natural green drug. The main structure of azulene is "azulene". "It is the active ingredient of chamomile flower. Sodium azulene sulfonate is prepared by adding water-soluble ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/43A61K8/46A61K8/49A61K8/92A61Q11/00
CPCA61K8/466A61K8/4926A61K8/43A61K8/345A61K8/922A61K8/34A61Q11/00Y02A50/30
Inventor 刘媛贾鹏云
Owner 北京华素制药股份有限公司
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