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Inhalable compositions comprising macrocyclic immunosuppressants

A technology of immunosuppression and composition, applied in the direction of inhalers, drug combinations, respirators, etc.

Pending Publication Date: 2021-02-12
呼吸治疗公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when using this nebulizer, some of the nebulized liquid will be expelled from the nebulizer during the user's exhalation

Method used

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  • Inhalable compositions comprising macrocyclic immunosuppressants
  • Inhalable compositions comprising macrocyclic immunosuppressants
  • Inhalable compositions comprising macrocyclic immunosuppressants

Examples

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Embodiment Construction

[0039] The terms "consisting of", "consisting of" and "consisting of" as used herein are so-called closed language, meaning that only the mentioned components are present. The terms "comprising", "including" and "comprising" used herein are so-called open language, meaning that one or more other components may or may not also exist.

[0040] The term "active ingredient" or "active pharmaceutical ingredient" (also referred to herein as "API") refers to any type of drug useful in the prevention, diagnosis, stabilization, treatment or (generally) management of a condition, disorder or disease active compound or derivative.

[0041] As used herein, the term "therapeutically effective amount" refers to a dose, concentration or strength that can be used to produce a desired pharmacological effect. In the context of the present invention, the term "therapeutically effective" also includes prophylactic activity. The determination of the therapeutic dose depends on the individual app...

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Abstract

The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease orcondition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (100), the nebulizer comprising: a) an aerosol generator (101) comprising: a fluid reservoir (103) for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and - a vibratable membrane (110) having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 15 4.0 um as measured with a 0.9 % (w / v) aqueous solution of sodium chloride; b) a chamber (105) for temporarily accommodating the aerosol generated by the aerosolgenerator (101), the chamber having an inner lumen with a volume in the range of from about 50 to about 150 ml; and c) a mouthpiece (40) for delivering the aerosol supplied by the nebulizer (100) to the subject, the mouthpiece having an exhalation filter (30).

Description

technical field [0001] The present invention relates to pharmaceutical compositions comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject. The pharmaceutical compositions of the invention may be administered by inhalation of an aerosol produced by a nebulizer comprising a vibratable membrane and a mixing chamber. Background technique [0002] WO 2007 / 065588 A1 discloses a liquid pharmaceutical composition suitable for pulmonary administration in aerosol form comprising a therapeutically effective dose of cyclosporine, an aqueous carrier liquid, a first solubilizing substance selected from phospholipids and a nonionic A second solubilizing substance for surfactants. [0003] A pharmaceutical composition as described above may be inhaled by a subject in need thereof. It should be noted that cyclosporines, such as cyclosporine A, like many other macrocyclic immunosuppress...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/13A61K9/00A61K9/127A61P11/00A61P37/06
CPCA61K38/13A61P11/00A61K9/127A61P37/06A61K9/0075A61M15/0085A61M11/005A61M15/0086A61M15/0021A61M16/1065A61M2202/0468A61M15/0015A61M15/0018B05B17/0646A61K9/00A61K9/0078A61K47/24A61K47/26A61M11/04A61M2205/75
Inventor 奥利弗·登克
Owner 呼吸治疗公司
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