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Sliding type microfluidic organ chip and preparation method thereof

A technology of microfluidic chips and organ chips, applied in chemical instruments and methods, biochemical equipment and methods, methods of supporting/immobilizing microorganisms, etc., to reduce processing time costs, innovate research ideas and application values, and operate flexibly high effect

Active Publication Date: 2021-02-12
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0007] In summary, the currently reported microfluidic organ chips have certain limitations in terms of reliable extracellular matrix perfusion, uniform distribution of fluid in tissue chambers, and cell / microtissue extraction. A new type of organ chip is urgently needed. Human organ chip design to enhance the stability and flexibility of related operations

Method used

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  • Sliding type microfluidic organ chip and preparation method thereof
  • Sliding type microfluidic organ chip and preparation method thereof
  • Sliding type microfluidic organ chip and preparation method thereof

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Embodiment Construction

[0045] The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

[0046] Figure 1-Figure 2 It is a schematic diagram of the overall structure of a sliding microfluidic organ chip in a preferred embodiment of the present invention. refer to Figure 1-Figure 2 As shown, in this embodiment, the sliding microfluidic organ chip includes: a sliding assembly 100 and a microfluidic chip base 200 . One end of the slide assembly 100 can be inserted into the microfluidic chip base 200 , and the other end is exposed outside the microfluidic chip base 200 and located on o...

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Abstract

The invention provides a sliding type micro-fluidic organ chip and a preparation method thereof. The sliding type micro-fluidic organ chip comprises a sliding assembly and a micro-fluidic chip base, wherein the sliding assembly is provided with a sliding rod, a glue injection opening, a sealing plug and an embedded tissue cavity, the glue injection opening is located over the embedded tissue cavity and communicates with the embedded tissue cavity, an extracellular matrix is injected into the top end of the glue injection opening, the embedded tissue cavity is filled with the extracellular matrix, the micro-fluidic chip base is provided with a sliding groove, a first exchange channel, a second exchange channel, a first liquid storage pool and a second liquid storage pool, the sliding rod ispushed into the bottommost portion of the sliding groove, at the moment, the two sides of the embedded tissue cavity are right opposite to a first exchange channel and a second exchange channel respectively, and the first liquid storage pool, the first exchange channel, the embedded tissue cavity, the second exchange channel and the second liquid storage pool are communicated. According to the invention, stable and reliable perfusion of the leakage-free extracellular matrix can be realized; and barrier-free contact between an extracellular matrix and a cell culture medium can be realized, anduniform and stable fluid characteristics can be realized in the extracellular matrix.

Description

technical field [0001] The invention belongs to a microfluidic chip in the technical field of biomedical engineering, and in particular relates to a sliding microfluidic organ chip and a preparation method thereof. Background technique [0002] Compared with traditional two-dimensional cell culture models and animal models with species differences, the human organ chip integrates human cells and hydrogels into the microfluidic chip to further simulate the construction of multiple controllable microenvironments in the body on the chip. Finally, in vitro realization of specific human organ microtissues with three-dimensional microstructure and microphysiological functions has attracted much attention. Therefore, this technology has been widely used in the fields of disease modeling, drug screening and personalized medicine. [0003] Usually, the three-dimensional culture model based on the perfusion mode is widely used in the construction of human-like organ chips. Its basic s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/00C12N5/00B01L3/00
CPCC12M21/08C12M23/16C12M23/38C12M23/52C12M25/14C12M37/04C12N5/0062B01L3/502707C12N2513/00C12N2503/02C12N2533/90B01L2300/042B01L2300/0861
Inventor 王晓林李钦宇
Owner SHANGHAI JIAO TONG UNIV
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