Macroporous adsorption resin for lincomycin extraction and synthesis method thereof

A technology of lincomycin and a synthesis method, which is applied in chemical instruments and methods, other chemical processes, alkali metal compounds, etc., can solve the problems of high production cost of macroporous adsorption resin, large emission of organic solvents, and low purity of finished products. , to achieve the effect of efficient extraction and industrial production, large adsorption capacity and high purity of finished products

Active Publication Date: 2021-02-12
西安蓝深新材料科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a macroporous adsorption resin for lincomycin extraction and a synthesis method thereof to solve the problems of high production cost and organic solvent discharge of the existing macroporous adsorption resin in view of the deficiencies in the prior art above. Large and small adsorption amount, low desorption rate and low purity of finished product in the extraction of lincomycin

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  • Macroporous adsorption resin for lincomycin extraction and synthesis method thereof
  • Macroporous adsorption resin for lincomycin extraction and synthesis method thereof
  • Macroporous adsorption resin for lincomycin extraction and synthesis method thereof

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preparation example Construction

[0032] A kind of synthetic method of macroporous adsorption resin for lincomycin extraction of the present invention comprises the following steps:

[0033] S1, synthesizing polystyrene-divinylbenzene type copolymer;

[0034] Add the dispersant and methylene blue into the water and heat, stir until completely dissolved to form the water phase; mix the monomer, porogen and initiator evenly as the oil phase; add the oil phase to the prepared water phase , let it stand for 5-10 minutes, after the oil phase and the water phase are completely separated, adjust the height and speed of the stirring paddle to control the particle size of the oil phase, stir at a constant speed after the particle size is appropriate, and then carry out heating and heat preservation operations; wash off with hot water after the reaction For the dispersant on the surface of the resin, the porogen inside the resin is extracted by water vapor extraction, and then washed and dried to obtain a polystyrene-di...

Embodiment 1

[0046] The oil phase mixture that will contain 100g divinylbenzene (content 80%), 150g tetramethylbenzene and 1.5g benzoyl peroxide is added to 500ml tap water, 2.5g polyvinyl alcohol, 2.5g hydroxyethyl cellulose and 0.025g times In the water phase solution composed of methylene blue, let it stand for 5 to 10 minutes. After the oil phase and the water phase are completely separated, adjust the stirring speed to make it into a uniform droplet of a certain size, then keep stirring at a constant speed and slowly heat up to 80 °C for 2 hours, 90 °C for 2 hours, and 95 °C for 6 hours. After the reaction is over, rinse the polystyrene-divinylbenzene copolymer with hot water, then add it to the steam extractor, perform steam purging at 90°C to recover the porogen tetramethylbenzene, and extract it into the outlet condensate There is almost no oily matter, the extraction is stopped, and finally the temperature is cooled and the material is discharged. The recovery rate of tetramethylb...

Embodiment 2

[0049] The oil phase mixture containing 100g divinylbenzene (content 80%), 150g recovery tetramethylbenzene and 1.5g benzoyl peroxide was added to 500ml tap water, 2.5g polyvinyl alcohol, 2.5g hydroxyethyl cellulose and 0.025g In the water phase solution composed of methylene blue solution, let it stand for 5 to 10 minutes. After the oil phase and the water phase are completely separated, adjust the stirring speed to make it into a uniform droplet of a certain size, and then keep stirring at a constant speed and slowly Raise the temperature to 80°C for 2 hours, 90°C for 2 hours, and 95°C for 6 hours. After the reaction is over, rinse the polystyrene-divinylbenzene copolymer with hot water, then add it to the steam extractor, perform steam purging at 95°C to recover the porogen tetramethylbenzene, and extract it into the outlet condensate There is almost no oily matter, the extraction is stopped, and finally the temperature is cooled and the material is discharged. The recovery...

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Abstract

The invention discloses macroporous adsorption resin for lincomycin extraction and a synthesis method thereof. The method comprises the following steps: stirring and dissolving in a suspension polymerization manner to prepare a water phase; dissolving a monomer, an initiator and a pore-foaming agent together, and stirring until the components are completely dissolved to prepare an oil phase; putting an oil phase into a water phase, standing until the oil phase and the water phase are completely layered, heating, and keeping the temperature; after the reaction is finished, putting the resin into a steam generator for extraction, recovering the pore-foaming agent, washing with water, and drying to obtain a dry polystyrene divinylbenzene copolymer; and adding the prepared dry polystyrene divinylbenzene copolymer into a reaction kettle, swelling with dichloroethane, adding a catalyst in twice, heating to react, washing the resin with water until the resin is neutral after the reaction is finished, discharging, and screening the macroporous adsorption resin to obtain the macroporous adsorption resin for lincomycin extraction. The macroporous adsorption resin prepared by the method not only has high adsorption capacity and high desorption rate on lincomycin, but also is simple in synthesis process, green, environment-friendly, low in cost and easy for large-scale production.

Description

technical field [0001] The invention belongs to the technical fields of chemical industry and medicine, and in particular relates to a macroporous adsorption resin for lincomycin extraction and a synthesis method thereof. Background technique [0002] Lincomycin, also known as lincomycin and lincomycin, is an alkaline broad-spectrum antibiotic that belongs to the macrolide antibiotics and is effective against most Gram-positive bacteria. In clinical practice, lincomycin is mainly used for the treatment of infections caused by Streptococcus pneumoniae, Streptococcus viridans and Staphylococcus aureus. Therefore, lincomycin has an extremely important position in the medical industry. [0003] For the extraction of lincomycin, the plate and frame filtration method was first used to extract lincomycin from the fermentation broth through solid-liquid separation, extraction, back extraction, concentrated crystallization and other processes. However, this method has many disadvan...

Claims

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Application Information

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IPC IPC(8): C08F212/08C08F212/36C08F2/20C08F8/02C08J9/28B01J20/26B01J20/28B01J20/30C07H15/16C07H1/06C08L25/08C08L25/02
CPCC08F212/08C08F212/36C08F8/02C08J9/28B01J20/261B01J20/28085B01J20/265C07H15/16C07H1/06C08J2201/04C08J2325/08C08J2205/042C08J2325/02C08F2/20
Inventor 刘耀龙冯志军张运孙冰杰
Owner 西安蓝深新材料科技股份有限公司
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