Hair growing method based on maternal hair stem cells and micro-needles

A technology of stem cells and microneedles, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of decreased metabolic function of hair follicles, restrictions on the application of transdermal drug delivery systems, and the function of dermal papilla Barriers and other problems to achieve the effect of promoting hair regeneration

Inactive Publication Date: 2021-01-29
麦迪森(江苏)医学研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. The dermal papilla in the hair follicle is dysfunctional;
[0006] 3. Reduced hair follicle metabolism;
[0007] 4. The inflammatory response attacks and destroys the environment around the hair follicle;
However, transdermal drug delivery also has its disadvantages. The barrier function of the stratum corneum of the skin can intercept a variety of macromolecules, which greatly limits the application of transdermal drug delivery systems. Therefore, this barrier has become a major problem for transdermal drug delivery systems.

Method used

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  • Hair growing method based on maternal hair stem cells and micro-needles
  • Hair growing method based on maternal hair stem cells and micro-needles
  • Hair growing method based on maternal hair stem cells and micro-needles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The ratio of hair mother stem cells to cell preservation solution is 1:0.1.

[0026] The cell preservation solution includes the following components by weight: 60 parts of deionized water, 1 part of tripotassium edetate, 20 parts of polyethylene glycol, 20 parts of disodium cromoglycate, and 20 parts of acetyl tetrapeptide-3.

Embodiment 2

[0028] The ratio of hair mother stem cells to cell preservation solution is 1:0.3.

[0029] The cell preservation solution includes the following components by weight: 75 parts of deionized water, 20 parts of tripotassium edetate, 5 parts of polyethylene glycol, 5 parts of disodium cromolyn, and 5 parts of acetyl tetrapeptide-3.

Embodiment 3

[0031] The ratio of hair mother stem cells to cell preservation solution is 1:0.5.

[0032] The cell preservation solution includes the following components by weight: 95 parts of deionized water, 5 parts of tripotassium edetate, 1 part of polyethylene glycol, 1 part of disodium cromoglycate, and 1 part of acetyl tetrapeptide-3.

[0033] The working principle of the present invention is that human hair mother stem cells are used as the main raw material, combined with the cell preservation solution, after entering the scalp, it can enhance the ability of anti-aging and scavenging free radicals, maintain scalp acid-base balance, normal metabolism, and provide hair follicles, scalp and skin A healthy microenvironment suppresses scalp inflammation. Hair mother stem cells inhibit the activity of 5-a reductase to act on dihydrotestosterone to reduce hair loss caused by androgenic excess. The cell preservation solution promotes protein growth in the extracellular matrix of the derm...

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Abstract

The invention discloses a hair growing method based on maternal hair stem cells and micro-needles. A transdermal delivery device based on the micro-needles is used, tiny gaps in the scalp surface aremanufactured through the micro-needles, cuticle barriers are broken through, and the maternal hair stem cells and cell preserving fluid used for transdermal delivery are directly delivered to the corium layer to be absorbed, so that the maternal hair stem cells and the cell preserving fluid directly and effectively play a role; the maternal hair stem cells and the cell preserving fluid are smearedon the surface of scalp, so that the maternal hair stem cells and the cell preserving fluid slowly permeate into scalp dermis tissues to realize hair regeneration. According to the invention, tiny gaps on the surface of scalp are artificially manufactured by utilizing a nano micro-needle technology and are used for transdermal delivery of maternal hair stem cells and cell preserving fluid so as to adjust periodic transformation of hair follicles and promote hair regeneration.

Description

technical field [0001] The invention relates to the technical field of hair growth, in particular to a hair growth method based on hair mother stem cells and microneedles. Background technique [0002] Hair loss with age is a common human condition that is generally thought to be related to immune dysfunction. Hair loss is a disease characterized by hair loss. Hair loss will affect the health of patients. In addition, hair loss affects the appearance to a certain extent. In the era of universal beauty, once hair loss occurs, people will think it is a serious problem! Common types of hair loss include androgenetic alopecia, alopecia areata, psoriatic alopecia, scalp discoid lupus erythematosus (DLE), etc. The researchers have shown through experiments that the expression of the surface markers CK15 and CD200 of hair mother stem cells in the hair follicles of patients with scalp DLE Both significantly decreased or disappeared, suggesting that hair follicle stem cells were sig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K35/36A61K47/10A61K47/18A61K47/22A61P17/14
CPCA61K9/0021A61K35/36A61K47/183A61K47/10A61K47/22A61P17/14
Inventor 汪超
Owner 麦迪森(江苏)医学研究有限公司
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