Application of 18β-glycyrrhetinic acid in the preparation of products that enhance the body's anti-fatigue ability
A glycyrrhetic acid, anti-fatigue technology, applied in the application field of the product, can solve the problems of the anti-fatigue effect that needs further verification, the suspicion of stimulants, and the high price.
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Embodiment 1
[0034] 18β-glycyrrhetinic acid alleviates exercise fatigue in mice in endurance exercise + high-intensity accelerated exercise fatigue model.
[0035] Test method: 36 male C57 BL / 6J mice, 6-8 weeks old, were randomly divided into a resting group (12 mice), a model group (12 mice), and a formula group (12 mice). By gastric administration, the rest group and the model group were administered 0.1% sodium carboxymethylcellulose every day, and the formula group was administered 25 mg / kg bw of 18β-glycyrrhetinic acid every day, and the solvent was 0.1% sodium carboxymethylcellulose. Gavage once a day at 8:30 in the morning. Supplementation continued for 3 days, and 2.5 hours after the last supplementation, the exercise exhaustion time of the mice was measured and the exercise distance was calculated.
[0036] Sports model: experimental animal treadmill. Slope 0°, initial speed 10m / min, increase 2m / min every 15min until 14m / min, accelerate to 20m / min after 15min, increase to 22m / mi...
Embodiment 2
[0040] 18β-glycyrrhetinic acid alleviates exercise fatigue in mice in a high-intensity accelerated exercise fatigue model.
[0041] Test method: 36 male C57 BL / 6J mice, 6-8 weeks old, were randomly divided into a resting group (12 mice), a model group (12 mice), and an administration group (12 mice). Adopt intragastric method, the rest group and the model group are intragastrically administered 0.1% sodium carboxymethylcellulose every day, and the administration group is intragastrically administered 25mg / kg bw of 18β-glycyrrhetinic acid every day, and the solvent is 0.1% sodium carboxymethylcellulose . Gavage once a day at 8:30 in the morning. Supplementation continued for 3 days, and 2.5 hours after the last supplementation, the exercise exhaustion time of the mice was measured and the exercise distance was calculated.
[0042] Sports model: experimental animal treadmill. The slope is 0°, the initial speed is 5m / min, increase by 5m / min every 5min, and after increasing to ...
Embodiment 3
[0047] 18β-glycyrrhetinic acid alleviates muscle damage in mice in a high-intensity accelerated exercise fatigue model.
[0048] Test method: 36 male C57 BL / 6J mice, 6-8 weeks old, were randomly divided into a resting group (12 mice), a model group (12 mice), and an administration group (12 mice). Adopt intragastric method, the rest group and the model group are intragastrically administered 0.1% sodium carboxymethylcellulose every day, and the administration group is intragastrically administered 25mg / kg bw of 18β-glycyrrhetinic acid every day, and the solvent is 0.1% sodium carboxymethylcellulose . Gavage once a day at 8:30 in the morning. Supplementation continued for 3 days, and 2.5 hours after the last supplementation, the mice in the model group and the administration group ran for 20 minutes uniformly, and blood was collected to determine the creatine kinase content in the serum of the mice.
[0049] Sports model: experimental animal treadmill. The slope is 0°, the i...
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