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Multifunctional bleeding arresting nanoparticles with low thrombosis risk, preparation method therefor and application of multifunctional bleeding arresting nanoparticles

A multi-functional, low-thrombosis technology, applied in the medical field, can solve problems such as limited clinical use, high blood coagulation risk, etc., achieve high-efficiency anti-infection performance and promote repair ability, reduce the risk of high coagulation, and promote the effect of blood coagulation function

Active Publication Date: 2021-01-22
CHONGQING UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the traditional hemostatic preparations and the new nano-hemostatic preparations are used to rapidly activate the coagulation and hemostasis mechanism; in local hemostasis, the rapid activation of coagulation function has no related side effects; however, for some internal bleeding and other situations that require systemic administration to stop bleeding, Although these hemostatic agents can exert rapid hemostasis ability, at the same time, due to the improvement of systemic blood coagulation function, after intravenous administration, it is easy to cause hypercoagulation risks such as thrombosis, which seriously limits their clinical use.

Method used

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  • Multifunctional bleeding arresting nanoparticles with low thrombosis risk, preparation method therefor and application of multifunctional bleeding arresting nanoparticles
  • Multifunctional bleeding arresting nanoparticles with low thrombosis risk, preparation method therefor and application of multifunctional bleeding arresting nanoparticles
  • Multifunctional bleeding arresting nanoparticles with low thrombosis risk, preparation method therefor and application of multifunctional bleeding arresting nanoparticles

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Effect test

Embodiment 1

[0036] This embodiment provides a multifunctional hemostatic nanoparticle with low risk of thrombosis, which consists of the following components in parts by weight: 1 part of polylysine and 2 parts of sulindac.

[0037] A method for preparing multifunctional hemostatic nanoparticles with low thrombosis risk, comprising the following steps: dissolving polylysine and sulindac in dimethyl sulfoxide respectively, and preparing poly Lysine premixed solution and sulindac premixed solution; the prepared polylysine premixed solution and sulindac premixed solution are transferred to a dialysis bag with a molecular weight cut-off of 1000Da in a ratio of 1:2 for dialysis, Hemostatic nanoparticles were prepared. The specific process parameters of dialysis are: maintain the room temperature at 4°C for dialysis; change the water every 30 minutes, after changing the water 4 times, then change the water every hour, take out the solution in the dialysis bag after 24 hours, and freeze-dry to o...

Embodiment 2

[0039] This embodiment provides a multifunctional hemostatic nanoparticle with low risk of thrombosis, which consists of the following components in parts by weight: 4 parts of polyarginine and 4 parts of sulindac.

[0040] A method for preparing multifunctional hemostatic nanoparticles with low thrombosis risk, comprising the following steps: respectively dissolving polyarginine and sulindac in methanol, respectively preparing polyarginine pre-prepared polyarginine with a concentration of 4 mg / ml; Mixed solution and sulindac premixed solution; the prepared polyarginine premixed solution and sulindac premixed solution were transferred to a dialysis bag with a molecular weight cut-off of 4000Da in a ratio of 1:2 for dialysis to obtain hemostatic nano grain. The specific process parameters of dialysis are: maintain the room temperature at 25°C for dialysis; change the water every 25 minutes, after changing the water 4 times, then change the water every hour, take out the solutio...

Embodiment 3

[0042] This embodiment provides a multifunctional hemostatic nanoparticle with low risk of thrombosis, which consists of the following components in parts by weight: 4 parts of polyglycine and 2 parts of sulindac.

[0043] A method for preparing multifunctional hemostatic nanoparticles with low thrombosis risk, comprising the following steps: respectively dissolving polyglycine and sulindac in ethanol, and preparing respectively polyglycine premixed solutions and sulindac with concentrations maintained at 1 mg / ml. Sulindac premixed solution: transfer the prepared polyglycine premixed solution and sulindac premixed solution in a ratio of 2:1 to a dialysis bag with a molecular weight cut-off of 10,000 Da for dialysis to obtain hemostatic nanoparticles. The specific process parameters of dialysis are: maintain the room temperature at 16°C for dialysis; first change the water every 15 minutes, then change the water every 30 minutes, and then change the water every hour. After 24 ho...

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Abstract

The invention relates to the technical field of medicines and discloses multifunctional bleeding arresting nanoparticles with low thrombosis risk. The multifunctional bleeding arresting nanoparticlesare prepared from the following ingredients in parts by weight: 1-4 parts of polypeptide with positive charges and 2-4 parts of prodrug of antiplatelet drugs. The invention further provides a preparation method for the multifunctional bleeding arresting nanoparticles with low thrombosis risk. The invention further provides application of the multifunctional bleeding arresting nanoparticles with low thrombosis risk. The multifunctional bleeding arresting nanoparticles can be used for efficiently arresting bleeding, resisting infection and promoting restoration and can be used for inhibiting a hypercoagulative state of blood in an organism and lowering the risk of thrombosis.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a low-thrombosis risk multifunctional hemostatic nanoparticle, a preparation method and an application thereof. Background technique [0002] Body bleeding includes external bleeding and internal bleeding; when the body has bleeding, it will lead to excessive blood loss, infection, wound formation and other problems; in the case of not serious damage, such as the destruction of some small blood vessels will stimulate the body to produce physiological hemostasis; but if If it is a relatively serious body injury, a series of measures must be taken to achieve rapid and effective hemostasis. Traditional pre-hospital trauma hemostatic products include medical gauze, tourniquet, wound paste, hemostatic powder, etc.; however, such hemostatic products only avoid the problem of excessive blood loss, and lack the effects of anti-infection and wound repair, which affects first aid. effici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/34A61K31/192A61P7/04
CPCA61K9/5146A61K31/192A61P7/04Y02A50/30
Inventor 周兴李晓辉刘嘉兴袁玉川
Owner CHONGQING UNIV OF TECH
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