High-collision-energy alternating voltage ion dissociation device and mass spectrometry method

Abstract

The invention provides a high-collision-energy alternating voltage ion dissociation device and a mass spectrometry method. The device is characterized in that the device comprises a pair of X electrodes which are parallel to each other, a pair of Y electrodes which are parallel to each other and a pair of end cover electrodes; and the X electrode pair and the Y electrode pair are parallel to eachother and have equal distances to the geometric center of the device. The at least one pair of electrodes is divided into two electrodes in the axial direction (the z direction is perpendicular to thexy plane). The phases of alternating voltages applied to the two electrodes on one side by a first alternating voltage power supply are opposite; and a second alternating voltage power supply appliesalternating voltage with the same or opposite phase as the output signal of the first alternating voltage power supply to the two electrodes on the other side. According to the high-collision-energyalternating ion dissociation device and method, the structure is simple, the machining and manufacturing cost is low, and the voltage applying mode is easy to achieve.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry, in particular to a high collision energy alternating voltage ion dissociation device and a mass spectrometry analysis method. Background technique [0002] Mass spectrometry is an analytical method for analyzing the composition of substances by measuring the mass-to-charge ratio of the measured sample ions. The sample to be tested is first ionized, and then the ions are separated according to the mass-to-charge ratio (m / z) to obtain a mass spectrum by using the different motion behaviors of different ions in the electric field or magnetic field. By analyzing the mass spectrum, the qualitative and quantitative results of the sample can be obtained. [0003] Ion trap mass spectrometer has the characteristics of fast analysis speed, high sensitivity and excellent analysis performance, especially suitable for tandem mass spectrometry analysis, and has been widely used in the field of molec...

AI Technical Summary

Problems solved by technology

The three-dimensional ion trap has high mass resolution, but also has the disadvantage of small storage capacity

However, the arc-shaped electrode rod used in this invention has the problems of high processing difficulty and difficult guarantee of precision.

Moreover, when it is used as a collision reaction cell, the application method of the collision alternating voltage is still the traditional dipole excitation method, and the excitation electric field is still symmetrical about the axis of the expelling direction, so it is still impossible to avoid the ion in a large alternating current. Ejection losses under voltage, with limitations

In the dipole excitation mode, the collision energy of ions is very sensitive to the change of the AC amplitude of the excitation voltage, which can easily cause the energy to be too high and cause the ions to fly out of the trap.

Therefore, the amplitude of the excitation alternating voltage AC is usually set to a small value, which limits the application of many other aspects, such as optimizing the internal alternating excitation electric field by adjusting the magnitude of the alternating voltage AC, etc.

In addition, due to the limitation of AC amplitude, ions gain energy slowly, which causes the problem of low ion collision efficiency.

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