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Polylactic acid elastic nonwoven material beneficial to tissue regeneration and preparation method thereof

A tissue regeneration, polylactic acid technology, applied in tissue regeneration, non-woven fabrics, textiles and papermaking, etc., can solve the problems of industrial production safety and environmental protection, affecting the fiber microstructure and use effect, nano-micron fiber web solvent residues and other problems, to achieve the effect of promoting wound healing and characteristic treatment, facilitating tissue fusion, and promoting rapid growth.

Active Publication Date: 2021-06-25
ZHONGYUAN ENGINEERING COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, in clinical applications, it is also found that there is a problem of delamination in the interlayer composite structure, which affects the microstructure and use effect of the fiber. There are insufficient safety and environmental protection

Method used

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  • Polylactic acid elastic nonwoven material beneficial to tissue regeneration and preparation method thereof
  • Polylactic acid elastic nonwoven material beneficial to tissue regeneration and preparation method thereof
  • Polylactic acid elastic nonwoven material beneficial to tissue regeneration and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0054] The preparation method of the polylactic acid elastic non-woven material beneficial to tissue regeneration, the steps are as follows:

[0055] (1) Preparation process of polyolefin elastic filament skeleton:

[0056] First, polyolefin elastic filaments with an average diameter of 100 μm and a circular cross-section were selected for antibacterial treatment.

[0057] The selected bio-based antibacterial material is chitosan solution, and a certain amount of chitosan is dissolved in citric acid with a mass fraction of 20% to form a chitosan solution with a mass fraction of 1%.

[0058] First, the prepared polyolefin filaments are treated with low-temperature plasma to introduce hydroxyl groups (—COOH) on the polyolefin filaments, and the hydroxyl groups can combine with the amino groups in chitosan, thereby fixing chitosan and giving it excellent antibacterial properties. Subsequently immerse it in the chitosan solution for 24 hours at 4°C, take it out and dry it; the a...

Embodiment 2

[0080] The preparation method of the polylactic acid elastic nonwoven material that is beneficial to tissue regeneration, the steps are as follows: the difference between this embodiment and embodiment 1 is that the average diameter of the polyolefin elastic filament used is 180 μm; °C, the average diameter of polylactic acid / polycaprolactone nano-micron fibers is 1.8 μm. In addition, adopting the same method as in Example 1 to obtain an areal density of 107.8 g / m 2 A polylactic acid elastic non-woven material that is beneficial to tissue regeneration, its characteristic test is shown in Table 1.

Embodiment 3

[0082] The preparation method of the polylactic acid elastic nonwoven material beneficial to tissue regeneration, the steps are as follows: the difference between this embodiment and embodiment 1 is that the functional polymer used is polyglycolide, and the average diameter of the polyolefin elastic filament used is 130 μm , the main component of the antibacterial layer used is chitosan / hyaluronic acid; at the same time, by increasing the temperature of the melt-blown die head to 230°C, increase the fan speed by 65r. min -1 , to achieve an average diameter of polylactic acid / polyglycolide nano-microfibers of 1.4 μm. In addition, adopting the same method as in Example 1 to obtain an areal density of 51.6 g / m 2 A polylactic acid elastic non-woven material that is beneficial to tissue regeneration, its characteristic test is shown in Table 1.

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Abstract

The invention discloses a polylactic acid elastic non-woven material beneficial to tissue regeneration and a preparation method thereof. The nano-micron polylactic acid elastic non-woven material is an integrated structure composed of polylactic acid nano-micron fibers as the main body and polyolefin elastic filaments as the skeleton. Its preparation method is as follows: the modified polylactic acid polymer and the polyolefin elastic skeleton are subjected to in-situ injection molding to obtain a laminated fiber web, and then the laminated fiber web is subjected to water jet composite processing to form an integrated structure, and then the integrated structure A fiber web is ironed on one side to obtain a nano-micron elastic lightweight patch and a preparation method thereof. The non-woven material prepared by this method has an integrated structure, no delamination and good anti-adhesion effect. At the same time, the non-woven material also has excellent elasticity and flexibility, and can be used for hernia patch, medical dressing, medical bandage, etc. multiple fields. The preparation method of the non-woven patch has the characteristics of short process flow, high production speed and low cost, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of nonwoven materials, and relates to a polylactic acid elastic nonwoven material beneficial to tissue regeneration, in particular to a polylactic acid elastic nonwoven material beneficial to tissue regeneration and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of medical fiber technology, functional non-woven materials based on specific raw materials can not only be used as substrates for cell culture to accelerate tissue growth, but also can be used to cover skin trauma, which is conducive to wound healing. Non-woven materials have been widely used in hernia patch, medical dressing, medical bandage and other fields for hernia repair and skin wound repair. [0003] Hernia means that a part of a human tissue or organ leaves its original location and enters another location through a gap, defect or weak part of the human body. It is commonly known as "hernia". ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4382D04H1/492D04H1/76D06C11/00A61F2/00A61L15/24A61L15/26A61L15/28A61L15/46A61L27/16A61L27/18A61L27/20A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61F2/0063A61L15/24A61L15/26A61L15/28A61L15/46A61L27/16A61L27/18A61L27/20A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/232A61L2300/404A61L2430/34D04H1/4382D04H1/492D04H1/76D06C11/00C08L67/04C08L23/02C08L5/08
Inventor 张恒甄琪崔景强程杰王先锋王国峰刘志远张永祥孙焕惟牛犇王诗文段泽平
Owner ZHONGYUAN ENGINEERING COLLEGE
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