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Application of Balanophora extract in preparation of anti-renal fibrosis drug

A technology of kidney fibrosis and extract, applied in the field of medicine, can solve problems such as hyperkalemia and acute renal failure.

Active Publication Date: 2021-01-01
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of ACEI and ARB is likely to lead to hyperkalemia and acute renal failure in patients with chronic kidney disease in the middle and late stages. There are restrictions on the use of pregnant women, renal artery stenosis, and non-hypertensive people, and they can only partially delay renal function. fibrosis progression

Method used

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  • Application of Balanophora extract in preparation of anti-renal fibrosis drug
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  • Application of Balanophora extract in preparation of anti-renal fibrosis drug

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Embodiment

[0024] 1. Drug source

[0025] The drug source in the present invention is consistent with the drug source in ZL201710972233.1 "Wenwang Yibi Extract and Its Application in the Preparation of Anticancer Drugs".

[0026] 2. Drug preparation and characteristic map research

[0027] The extraction and preparation method of the Wenwangyibi water-extracted and alcohol-precipitated part extract (BPP) in the present invention is the same as the patent "Wenwangyibi Extract and Its Application in the Preparation of Anticancer Drugs" (Patent No. ZL201710972233.1 ) in the same method, specifically FrP in the patent; its characteristic map is the same as that of the corresponding part of the extract in the patent "Wen Wang Yibi Extract and Its Application in the Preparation of Anticancer Drugs" (Patent No. ZL201710972233.1) The feature maps are consistent.

[0028] The extract from the water-extracted and alcohol-precipitated part is further decolorized and refined to obtain refined ingr...

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Abstract

The invention discloses an application of Balanophora extract in preparation of an anti-renal fibrosis drug. The Balanophora extract is water extract or water extraction and alcohol precipitation extract. The Balanophora water extraction and alcohol precipitation extract (BPP) can inhibit UUO-induced mouse renal interstitial injury and fibrosis, and has a certain protection effect on the UUO-induced mouse renal function. Further researches show that the BPP inhibits the expression of Collagen I, Collagen III and Collagen IV to inhibit the renal fibrosis; By adopting the BPP, in an animal experiment process, death of a mouse is not found, and obvious abnormal liver and kidney functions of the mouse are not observed, which indicates that the extract has better safety. The Balanophora water extraction and alcohol precipitation extract can be applied to preparation of anti-renal fibrosis drugs and pharmaceutical compositions.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of a Wenwangyibi extract in the preparation of anti-renal fibrosis medicines. Background technique [0002] Chronic renal failure (CRF) has become one of the major diseases affecting global human public health. Renal interstitial fibrosis is one of the main pathological features of CRF. It is a common pathway for various kidney diseases to develop into end-stage renal disease, and it is the only way for CRF. At present, it is believed that the pathological changes of end-stage renal disease are irreversible; therefore, prevention and treatment of the occurrence and development of renal fibrosis is very important, and it is the key to the prevention and treatment of CRF. The pathogenesis of renal fibrosis is extremely complex, and it is a slow process of multi-factor and multi-link interaction. Inflammation etc. For a long time, the clinical treatment of renal fibrosis ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/12
CPCA61K36/185A61K2236/331A61K2236/55A61P13/12
Inventor 袁成福何毓敏周刚肖莉彭帆
Owner CHINA THREE GORGES UNIV
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