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Pharmaceutical composition for preventing and/or treating novel coronavirus pneumonia as well as preparation method and application thereof

A composition and drug technology, applied in the direction of drug combination, antiviral agent, pharmaceutical formula, etc., can solve the problems of low treatment efficiency, limited clinical application, large side effects, etc., shorten the course of fever, simple preparation process, suitable for The effect of industrial production

Active Publication Date: 2020-12-29
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have low therapeutic efficiency and high mortality rate; and their side effects are large, which limits clinical application

Method used

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  • Pharmaceutical composition for preventing and/or treating novel coronavirus pneumonia as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]Example 1. Preparation of the pharmaceutical composition of the present invention

[0026]Recipe: 3 grams of ephedra, 4 grams of almonds, 8 grams of raw gypsum, 6 grams of roasted licorice, 6 grams of ground dragon, 8 grams of northern five flavors, 4 grams of attached tablets, 3 grams of ginger, 8 grams of atractylodes, 10 grams of white peony, Poria cocos 10 grams, 3 grams of ginseng, 6 grams of peach kernels, 6 grams of safflower, 6 grams of three-lens, 6 grams of turmeric, and 10 grams of rhodiola.

[0027]Process:

[0028](1) Pretreatment: Weigh the raw gypsum according to the weight ratio, make the attached piece, and fry it for 30 minutes;

[0029](2) Soak all the APIs in the formula except for gypsum and attached tablets for 30 minutes in 1500ml water, then add the soaked APIs and water to the system obtained in step (1), boil on high fire, and fry Boil for 20 minutes and filter; add 1000 ml of water to the medicine residue, boil on high fire, continue to decoct for 30 minutes, an...

Embodiment 2

[0030]Example 2. Preparation of the pharmaceutical composition of the present invention

[0031]Recipe: 2 grams of ephedra, 3 grams of almonds, 7 grams of raw gypsum, 5 grams of roasted licorice, 5 grams of ground dragon, 7 grams of North five flavors, 3 grams of attached tablets, 2 grams of ginger, 7 grams of atractylodes, 9 grams of white peony, Poria cocos 9 grams, 2 grams of ginseng, 5 grams of peach kernels, 5 grams of safflower, 5 grams of tricorne, 5 grams of turmeric, and 9 grams of rhodiola.

[0032]Process: Same as Example 1.

Embodiment 3

[0033]Example 3. Preparation of the pharmaceutical composition of the present invention

[0034]Recipe: 4 grams of ephedra, 5 grams of almonds, 9 grams of raw gypsum, 7 grams of roasted licorice, 7 grams of ground dragon, 9 grams of northern five flavors, 5 grams of attached tablets, 4 grams of ginger, 9 grams of Atractylodes macrocephala, 11 grams of white peony root, Poria cocos 11 grams, 4 grams of ginseng, 7 grams of peach kernels, 7 grams of safflower, 7 grams of three-row, 7 grams of turmeric, 11 grams of rhodiola.

[0035]Process: Same as Example 1.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for preventing and / or treating novel coronavirus pneumonia as well as a preparation method and application thereof. The pharmaceutical compositionis composed of 17 raw material medicines such as semen persicae, flos carthami, rhizoma sparganii, rhizoma curcumae, herba rhodiolae and the like. The pharmaceutical composition has a good treatmenteffect on the novel coronavirus pneumonia and can inhibit the trend of converting the common novel coronavirus pneumonia into the severe / critical novel coronavirus pneumonia; and after the pharmaceutical composition is taken, the cure and hospital discharge rate of severe / critical patients reaches up to 79.7%, and the total cure and hospital discharge rate of the severe / critical patients reaches up to 80.1%. The pharmaceutical composition can also shorten the fever course of the patients, reduce the hospitalization days of the patients and reduce the total cost. The pharmaceutical compositiondisclosed by the invention has a very good application prospect in preparation of drugs for preventing and / or treating the novel coronavirus pneumonia.

Description

Technical field[0001]The invention belongs to the field of medicine, and specifically relates to a pharmaceutical composition for preventing and / or treating novel coronavirus pneumonia and a preparation method and application thereof.Background technique[0002]Corona Virus Disease 2019 (COVID-19), abbreviated as "New Coronary Pneumonia", is a new type of viral pneumonia that started in December 2019. It has become a global epidemic and is classified as a global outbreak. Public health incident. The new coronavirus pneumonia is extremely contagious and the population is generally susceptible.[0003]At present, the recommended drugs for new coronavirus pneumonia are lopinavir / ritonavir (200mg / 50mg / capsule for adults, 2 capsules each time, 2 times a day), or chloroquine phosphate (adults aged 18-65 years) , For those who weigh more than 50 kg, 500 mg each time, 2 times a day; For those who weigh less than 50 kg, 500 mg each time on the first or two days, 2 times a day, from the third day...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P31/14A61P11/00A61K33/06A61K35/62
CPCA61K33/06A61K35/62A61K36/076A61K36/17A61K36/258A61K36/284A61K36/286A61K36/41A61K36/484A61K36/57A61K36/65A61K36/71A61K36/714A61K36/736A61K36/79A61K36/902A61K36/9066A61K36/9068A61K2236/331A61K2236/39A61K2236/51A61P11/00A61P31/14A61K2300/00
Inventor 扈晓宇陈婧骆建兴刘海
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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