Deep flexible brain electrode combined with drug delivery channel and preparation method of deep flexible brain electrode

Abstract

The invention discloses a deep flexible brain electrode combined with a drug delivery channel and a preparation method of deep flexible brain electrode. The deep flexible brain electrode comprises a flexible electrode body and a flexible drug delivery channel parallel to the surface of the flexible electrode body; a silicon substrate is arranged at the rear end of the flexible electrode body; oneend of the flexible drug delivery channel is fixed to the silicon substrate; and a flexible implantation part of the flexible electrode body is attached to the flexible drug delivery channel in parallel. The flexible drug delivery channel is arranged in the flexible electrode body, and the combined deep flexible brain electrode is flexible as a whole and has high biocompatibility and longer service life. The combined operation of the flexible drug delivery channel and the flexible electrode body is relatively convenient and simple, and the assembly success rate is relatively high. The deep flexible brain electrode can achieve drug stimulation and electrophysiological recording at the same time.

Description

technical field [0001] The invention relates to the technical field of brain function detection, in particular to a deep flexible brain electrode combined with a drug delivery channel and a preparation method thereof. Background technique [0002] Implantable neural probes are the most widespread tool for recording neural activity at single-cell, submillisecond resolution, but their signals tend to fade over time due to chronic inflammatory responses and neuronal cell deactivation around the implant site. And degenerate. The failure to implant neural probes for long-term recording is one of the most critical challenges in longitudinal studies of cognitive functions (such as learning and memory) and in high-fidelity neural prosthetics. Experimental evidence suggests that flexible neural probes with mechanical strength close to that of brain tissue can reduce relative shear motion, thereby improving the stability of electrode recordings and their working lifetime. [0003] M...

AI Technical Summary

Problems solved by technology

However, this type of electrode is mostly a hard silicon-based electrode, which has the disadvantages of large implantation marks, easy to cause rejection and intracranial tissue damage

These shortcomings seriously affect the working life of this type of drug delivery electrode, making it difficult to apply to behavioral and intracranial virus expression experiments with a long experimental cycle

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